Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents was written by Birgul, Kaan;Uba, Abdullah Ibrahim;Cuhadar, Ozan;Sevinc, Sevgi Kocyigit;Tiryaki, Selen;Tiber, Pinar Mega;Orun, Oya;Telci, Dilek;Yilmaz, Ozgur;Yelekci, Kemal;Guniz Kucukguzel, S.. And the article was included in Journal of Molecular Structure in 2022.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
New thiosemicarbazides, 1,2,4-triazoles and thioethers I (R1 = Ph, 4-FC6H4, Bn, etc.; R2 = Bn, 3-FC6H4CH2, 4-MeOC6H4CH2, etc.) from derived (S)-Naproxen were synthesized in this study. The mol. binding of the compounds on MetAP-2 was performed. Anticancer effects of the synthesized compounds were studied by using MTT assay method on MCF-7 (includes estrogen and progesterone receptors) and MDA-MB-231 (lacks estrogen and progesterone receptors) adenocarcinoma cell lines at 0, 10, 25, 50, 75 and 100μM concentrations for 24 h. The IC50 values of novel (S)-Naproxen derivatives were determined between from 5 to 100μM on MCF-7 breast cancer cell line and MDA-MB-231 cell lines. The apoptotic activity of selected compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) were first analyzed by Annexin V staining using Tali Image-Based Cytometer. Mitochondrial membrane potential changes determined in fluorescence plate reader following JC-1 stain for compounds I (R1 = 4-ClC6H4; R2 = 3-FC6H4CH2) and I (R1 = Ph; R2 = 4-MeC6H4CH2) in MCF-7 and MDA-MB-231 cells. The effect of these compounds on the cell viability 4T1 mouse mammary tumor cell line was tested at 1 to 5 times of calculated IC50 value (IC50x1, IC50x2, IC50x3, IC50x4, and IC50x5). Next in order to determine the toxicity of the combination of compound I (R1 = Bn; R2 = 3-FC6H4CH2) and Docetaxel, WST-1 cell viability and proliferation assay was performed with 4T1. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics