Month: January 2023

Pentacoordinated spirophosphoranide as Lewis base to activate CO₂ combining with alkyl halide under mild conditions was written by Wang, Di;Guo, Shanqi;Wang, Yanyan;Liu, Qiangqiang;Sun, Can;Guo, Yanchun;Zhao, Yufen;Cao, Shuxia. And the article was included in Tetrahedron in 2022.Synthetic Route of C8H9Cl This article mentions the following:

A transition metal-free method to activate CO₂ by pentacoordinated spirophosphoranide that acts as Lewis base at room temperature and under atm. pressure is reported. The reaction of hydrospirophosphorane, CO₂ and alkyl halide could perform smoothly under mild conditions, and the product with a pentacoordinated P-C(O)-O-C unit could be obtained. The stereochem. mechanism was proposed by ³¹P NMR tracking experiment, ESI-MS/MS tracking experiment, X-Ray anal. and DFT calculations The reaction was presumed to proceed via a spoirophosphoranecarboxylate anion intermediate, and the phosphorus configuration was maintained throughout the reaction. The results show that pentacoordinated hydrospirophosphorane is a potential skeleton to capture and activate CO₂, and can be used to establish a novel utility of CO₂ in organic synthesis. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Synthetic Route of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed Synthesis of Tricyclic Indoles via a N-S Bond Cleavage Strategy was written by Zhang, Bo-Sheng;Wang, Fan;Gou, Xue-Ya;Yang, Ying-Hui;Jia, Wan-Yuan;Liang, Yong-Min;Wang, Xi-Cun;Li, Yuke;Quan, Zheng-Jun. And the article was included in Organic Letters in 2021.Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

In palladium/norbornene (Pd/NBE) chem., the “ortho effect” has been proven to be a key factor in the process of β-carbon elimination to extrude NBE. Herein, it is found that the o-iodoaniline protected by a p-methoxybenzenesulfonyl group can recover the “ortho effect” and then undergo N-S bond cleavage with vinyl palladium, thus achieving a highly selective C-N coupling reaction in the Catallani-Lautens reaction system. On the basis of this discovery, a one-step synthesis of highly functionalized tricyclic indole derivatives was realized. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base mediated direct C-H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants was written by Guo, Wei. And the article was included in Chinese Chemical Letters in 2016.Synthetic Route of C7H8Cl2N2 This article mentions the following:

A direct metal-free C-H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodol. provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction conditions using oxygen as the sole oxidant. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Synthetic Route of C7H8Cl2N2).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C7H8Cl2N2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Decarboxylative oxygenation of carboxylic acids with O₂via a non-heme manganese catalyst was written by Guan, Renpeng;Bennett, Elliot L.;Huang, Zhiliang;Xiao, Jianliang. And the article was included in Green Chemistry in 2022.Application of 76-83-5 This article mentions the following:

Decarboxylative oxygenation of carboxylic acids using a non-heme manganese catalyst under blue light irradiation with O₂ as the sole oxidant. Featuring mild reaction conditions, the protocol allowed readily available carboxylic acids to be converted into a wide variety of valuable aldehydes, ketones and amides. Mechanistic studies indicated that the decarboxylation and oxygenation involved the formation of active Mn-oxygen species. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics