Month: January 2023

Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists was written by Kojima, Takuto;Mochizuki, Michiyo;Takai, Takafumi;Hoashi, Yasutaka;Morimoto, Sachie;Seto, Masaki;Nakamura, Minoru;Kobayashi, Katsumi;Sako, Yuu;Tanaka, Maiko;Kanzaki, Naoyuki;Kosugi, Yohei;Yano, Takahiko;Aso, Kazuyoshi. And the article was included in Bioorganic & Medicinal Chemistry in 2018.HPLC of Formula: 6590-96-1 This article mentions the following:

A new class of corticotropin releasing factor 1 (CRF₁) receptor antagonists characterized by a tricyclic core ring was designed and synthesized. Novel tricyclic derivatives 2a-e were designed as CRF₁ receptor antagonists based on conformation anal. of our original 2-anilinobenzimidazole CRF₁ receptor antagonist. The synthesized tricyclic derivatives 2a-e showed CRF₁ receptor binding activity with IC₅₀ values of less than 400nM, and the 1,2,3,4-tetrahydropyrimido-[1,2-a]benzimidazole derivative 2e was selected as a lead compound with potent in vitro CRF₁ receptor binding activity (IC₅₀=7.1nM). To optimize the pharmacokinetic profiles of lead compound 2e, we explored suitable substituents on the 1-position and 6-position, leading to the identification of compound 42c-R, which exhibited potent CRF₁ receptor binding activity (IC₅₀=58nM) with good oral bioavailability (F=68% in rats). Compound 42c-R exhibited dose-dependent inhibition of [¹²⁵I]-CRF binding in the frontal cortex (5 and 10mg/kg, p.o.) as well as suppression of locomotor activation induced by intracerebroventricular administration of CRF in rats (10mg/kg, p.o.). These results suggest that compound 42c-R successfully binds CRF₁ receptors in the brain and exhibits the potential to be further examined for clin. studies. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Simplifying Nickel(0) Catalysis: An Air-Stable Nickel Precatalyst for the Internally Selective Benzylation of Terminal Alkenes was written by Standley, Eric A.;Jamison, Timothy F.. And the article was included in Journal of the American Chemical Society in 2013.Related Products of 697-73-4 This article mentions the following:

The synthesis and characterization of the air-stable nickel(II) complex trans-(PCy₂Ph)₂Ni(o-tolyl)Cl is described in conjunction with an investigation of its use for the Mizoroki-Heck-type, room temperature, internally selective coupling of substituted benzyl chlorides with terminal alkenes. This reaction, which employs a terminal alkene as an alkenylmetal equivalent, provides rapid, convergent access to substituted allylbenzene derivatives in high yield and with regioselectivity greater than 95:5 in nearly all cases. The reaction is operationally simple, can be carried out on the benchtop with no purification or degassing of solvents or reagents, and requires no exclusion of air or water during setup. Synthesis of the precatalyst is accomplished through a straightforward procedure that employs inexpensive, com. available reagents, requires no purification steps, and proceeds in high yield. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Related Products of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Mediated Three-Component Tandem Reactions for the Synthesis of Multisubstituted Pyrimidines was written by Liu, Dongqing;Guo, Wei;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Journal of Organic Chemistry in 2017.Quality Control of 2-Chloro-benzamidine hydrochloride This article mentions the following:

A base-mediated three-component tandem reaction for the synthesis of multi-substituted pyrimidines from amidines, aryl alkynes, and aldehydes in a one-pot manner has been developed. Advantages of this transformation include being transition-metal-free, high efficiency, available starting materials, and being environmentally friendly. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Quality Control of 2-Chloro-benzamidine hydrochloride).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 2-Chloro-benzamidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzo[f]naphthyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens was written by Tabart, Michel;Picaut, Guy;Lavergne, Marc;Wentzler, Sylvie;Malleron, Jean-Luc;Dutka-Malen, Sylvie;Berthaud, Nadine. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Computed Properties of C6H4ClF2N This article mentions the following:

The synthesis and antibacterial activity of benzo[f][1,7]naphthyridones, e.g., I, are reported. These compounds are potent antibacterial agents with a Gram-pos. spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chem. and biol. properties make them particularly suitable for topical antibacterial use. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5Computed Properties of C6H4ClF2N).

3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C6H4ClF2N

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Research on characteristics of composition and sedimentation separation of high calcium-type ASP produced water was written by Zhang, Jie;Hu, Hai-bing;Wei, Li;Li, Chun-ying;Yu, Gang. And the article was included in Harbin Shangye Daxue Xuebao, Ziran Kexueban in 2014.Formula: C18H37Cl This article mentions the following:

ASP-flooding is a new kind of flooding technol. The produced water reinjection is an important issue restricting the tech. promotion. Three-dimensional fluorescence spectra and GC-MS were applied for the research. The composition of organic and oil/water separation characteristics were studied. Results indicated that much more calcium ions and silicium ions could be detected in the high calcium-type ASP produced water. The value of BOD/COD was 0.1654. It had bad biodegradability, belonging to moderate salt industrial waste water. The kinds of main organic matters were 78. The extraction agent of Me tert-Bu ether was primarily hydrocarbons and alkanes. The extraction agent of n-hexane was a toxic matter, such as benzene series and naphthaline. After phys. sedimentation, the oil removal rate was 81.34%, and the suspended solids removal rate was 85.45%. The speed of oil-water separation was slow. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Site-Selective Carbene-Induced C-H Functionalization Catalyzed by Dirhodium Tetrakis(triarylcyclopropanecarboxylate) Complexes was written by Liao, Kuangbiao;Liu, Wenbin;Niemeyer, Zachary L.;Ren, Zhi;Bacsa, John;Musaev, Djamaladdin G.;Sigman, Mathew S.;Davies, Huw M. L.. And the article was included in ACS Catalysis in 2018.Reference of 7476-66-6 This article mentions the following:

Three types of dirhodium tetrakis(triarylcyclopropanecarboxylate) complexes were generated and shown to adopt disparate high-symmetry structures. These catalysts were evaluated in the intermol. C-H functionalization of an array of terminally substituted n-alkanes and displayed various site-selectivity as a function of catalyst and substrate structure, which could be correlated through quant. relationships. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Reference of 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recyclable palladium-catalyzed cyclocarbonylation between benzyl chlorides and salicylic aldehydes towards coumarins was written by Zhou, Yan;Zhou, Zebiao;Liu, Siqi;Cai, Mingzhong. And the article was included in Molecular Catalysis in 2022.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

A novel and practical route to coumarin derivatives was developed via the heterogeneous Pd-catalyzed carbonylative reaction and subsequent intramol. condensation process starting from com. easily available benzyl chlorides and salicylic aldehydes. Reactions were performed in the existence of 2 mol% of an SBA-15-immobilized bidentate phosphine palladium complex [SBA-15-P,P-PdCl2] in dioxane at 110°C with Et₃N as base under 10 bar of CO to afford a wide range of coumarin derivatives mostly with good to high yields. Importantly, this new heterogenized palladium complex was easy to recover via filtration of the reaction mixture, and was recyclable up to 8 times without apparent drop in its catalytic performance. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nano-ferrous ferric oxide (nano-Fe₃O₄). Powerful, reusable, and stable catalyst for N-Boc protection of amines was written by Zolfigol, Mohammad Ali;Moosavi-Zare, Ahmad Reza;Moosavi, Parvin;Khakyzadeh, Vahid;Zare, Abdolkarim. And the article was included in Comptes Rendus Chimie in 2013.Name: tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

Nano-ferrous ferric oxide (nano-Fe₃O₄) efficiently catalyzed N-boc protection of amines in high yields and acceptable reaction times. Nano-Fe₃O₄ was applied as an efficient, green, heterogeneous and reusable magnetite catalyst. Clean reaction, simple purification, short reaction time and high yield were some other advantages of this compound In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Name: tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A novel one-pot synthesis of N,6-disubstituted 1,3,5-triazine-4,6-diamines from isothiocyanates and amidines was written by Liu, Chunjian;Lin, James;Leftheris, Katerina. And the article was included in Tetrahedron Letters in 2007.SDS of cas: 6590-96-1 This article mentions the following:

A one-pot procedure for the preparation of N,6-disubstituted-1,3,5-triazine-2,4-diamines and its scope of application are demonstrated with a number of examples. The procedure involves the treatment of isothiocyanates with sodium hydrogen cyanamide, followed by amidines in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1SDS of cas: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity was written by Szucova, Lucie;Travnicek, Zdenek;Zatloukal, Marek;Popa, Igor. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Category: chlorides-buliding-blocks This article mentions the following:

The Pt(II) and Pd(II) complexes of the types cis-[Pt(L₁)₂Cl₂]·H₂O (1), cis-[Pt(L₂)₂Cl₂]·3H₂O (2), trans-[Pd(L₁)₂Cl₂]·H₂O (3), trans-[Pd(L₂)₂Cl₂]·H₂O (4), trans-[Pd(L₃)₂Cl₂]·2DMF (5) and trans-[Pd(L₄)₂Cl₂]·2DMF (6) (L₁-L₄ = cyclin-dependent kinase inhibitors derived from 6-benzylamino-9-isopropylpurine) have been prepared and characterized. The complexes have been studied by elemental analyses, conductivity measurements, ES+ MS, FT-IR, ¹H, ¹³C and ¹⁹⁵Pt NMR spectra, differential scanning calorimetry and thermogravimetric anal. The mol. structures of L₁, trans-[Pd(L₃)₂Cl₂]·2DMF (5) and trans-[Pd(L₄)₂Cl₂]·2DMF (6) have been determined by single crystal x-ray anal. The complexes have been tested in vitro due to their presumable anticancer activity against the following human cancer cell lines: K-562, MCF7, G-361 and HOS. Satisfying results were obtained for the complex 1 with IC₅₀ values of 6 μM acquired against G-361 as well as against HOS cell lines. The lowest values of IC₅₀ were achieved for the complexes 3 and 4 against MCF 7 cell line with IC₅₀ 3 μM (for 3) and also 3 μM (for 4). In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Category: chlorides-buliding-blocks).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics