Month: January 2023

Synergistic degradation of Methylene Blue by novel Fe-Co bimetallic catalyst supported on waste silica in photo-Fenton-like system was written by Quiton, Khyle Glainmer N.;Lu, Ming-Chun;Huang, Yao-Hui. And the article was included in Sustainable Environment Research in 2022.Product Details of 61-73-4 This article mentions the following:

In this present study, a novel method to fabricate bimetallic Fe-Co catalyst supported on waste silica was investigated for the photo-Fenton-like (PFL) degradation of Methylene Blue (MB) dye. The uniqueness of this work is on the preparation of the catalyst via fluidized-bed crystallization (FBC) process. Under the optimum conditions of initial pH of 3.0, 3.0 mM of H2O2, and 1.0 g L-1 of FBC-derived Fe-Co/SiO2 catalyst (fFCS), the maximum response for the decoloration and mineralization efficiencies of 20 mg L-1 of MB in 60 min were 100 and 65%, resp. Compared to the impregnated Fe-Co/SiO2 catalyst, the fFCS catalyst exhibited comparable decoloration and mineralization efficiencies, and relatively lower metal leaching for both iron and cobalt. Superoxide radical was unveiled to be the dominant reactive oxygen species in the PFL system over the fFCS catalyst. The catalysts were characterized by Fourier Transform IR spectroscopy, Energy Dispersive X-ray spectroscopy and SEM. The results show the successful incorporation of iron and cobalt on the surface of the SiO2 support material. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Product Details of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors was written by Giampietro, Letizia;Gallorini, Marialucia;Gambacorta, Nicola;Ammazzalorso, Alessandra;De Filippis, Barbara;Della Valle, Alice;Fantacuzzi, Marialuigia;Maccallini, Cristina;Mollica, Adriano;Cataldi, Amelia;Nicolotti, Orazio;Amoroso, Rosa. And the article was included in European Journal of Medicinal Chemistry in 2021.Reference of 63624-28-2 This article mentions the following:

In this respect, a series of phenyldiazenyl sulfonamides (E)-RS(O)₂NHC₆H₄N=NC₆H₅ (R = Me, Ph, 5-chlorothiophen-2-yl, etc.) and (E)-I was designed, synthesized and tested. Compounds (E)-RS(O)₂NHC₆H₄N=NC₆H₅ (R = 4-cyanophenyl, 2,4-dimethoxyphenyl (II)), and (E)-I (R = 2,4-dimethoxyphenyl) showed an aromatase inhibition in the micromolar range and were evaluated in vitro on the human breast cancer cell line MCF7 by MTT assay, cytotoxicity assay (LDH release), cell cycle anal. and apoptosis, revealing a dose-dependent inhibition profile. In particular, (II) displayed the best reduction in terms of metabolic activity and an anti-proliferative effect on MCF7 cells, being blocked in the G1/S phase checkpoint. Moreover, computational studies were carried out to better understand at a mol. level of detail the rationale behind the effective binding to the active site of aromatase of the more active inhibitor (II). The obtained results allow to consider this compound as an interesting lead for the development of a new class of non-steroidal aromatase inhibitors. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pyridonecarboxylic acids as antibacterial agents. VII. Synthesis and antibacterial activities of 1-(p-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-substituted pyridino[2,3-c]pyridazine-3-carboxylic acids was written by Mu, Yongqi;Guo, Huiyuan;Zhang, Zhiping. And the article was included in Zhongguo Kangshengsu Zazhi in 1989.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

Title compound, I (R = OH, Cl, NHNH₂, NH₂, NMe₂, NHMe, PhO, 4-FC₆HeNH, cyclopropylamino, pyrrolidino, piperidino, morpholino, piperazino, N–methylpiperazino) were prepared from pyridine II (Z = H₂) via cyclization of II (Z = 4-FC₆H₄NHN:). I had a min. inhibitory concentration of âˆ?00 μg/mL against E. coli 1515. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Scalable Pillar[5]arene-Integrated Poly(arylate-amide) Molecular Sieve Membranes to Separate Light Gases was written by Song, Woochul;Park, Jaesung;Dasgupta, Subhadeep;Yao, Chenhao;Maroli, Nikhil;Behera, Harekrushna;Yin, Xinyang;Acharya, Durga P.;Zhang, Xueyi;Doherty, Cara M.;Maiti, Prabal K.;Freeman, Benny D.;Kumar, Manish. And the article was included in Chemistry of Materials in 2022.Formula: C9H3Cl3O3 This article mentions the following:

Mol. sieve membranes and their analogs could potentially transform energy-intensive gas separation processes. However, many such membranes suffer from either limited processability or phys. stability including plasticization of semi-flexible microstructures. Here, we report on a new variation of all-polymer-based mol. sieve membranes that could tackle these specific challenges. These membranes were prepared by the interfacial polymerization of pillar[5]arene, m-phenylenediamine, and trimesoyl chloride to create characteristic poly(arylate-amide) heteropolymer microstructures. Pillar[5]arenes were crosslinked into the films with net weight fractions of up to ~47%, wherein the 4.7 Å cavities of pillar[5]arenes were interconnected with ~2.8 Å apertures. These microstructures provided preferred permeation paths for smaller mols. (He and H₂) among the tested light gases (He, H₂, CO₂, O₂, N₂, and CH₄) and resulted in significant mol. sieving effects with representative pure gas selectivities of 32 (H₂/CO₂), 150 (CO₂/CH₄), 4600 (H₂/CH₄), 13 (O₂/N₂), and 4.7 (N₂/CH₄) at 35°C and 10 atm. These separation factors outperform most polymer-based gas separation membranes, while providing membrane features such as thin film barriers, cross-linked polymer backbones, and excellent processability resulting from interfacial polymerization that are critical for large-scale operations. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Formula: C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Conventional and non-conventional synthesis of some novel benzofuran incorporated thiadiazoles and triazoles was written by Kundlikar, S. G.;Randhavane, P. V.;Akolkar, H. N.;Karale, B. K.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2016.Safety of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

7-Bromo-5-chlorobenzofuran-2-carbohydrazide on reaction with substituted arylisothiocyanates gave corresponding thiosemicarbazides, further reaction in the presence of acidic and basic medium gave corresponding thiadiazoles and triazoles resp. The structures of all the synthesized compounds were characterized with the help of spectral techniques. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Safety of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of calycanthaceous alkaloid analogs was written by Zheng, Shaojun;Zhu, Rui;Zhou, Xinping;Chen, Lizhuang;Bai, Hongjin;Zhang, Jiwen. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Starting from 9-methyl-1,2,3,4,9,9a-hexahydro-4aH-pyrido[2,3-b]indol-4a-ol, or indole-3-acetonitrile, 40 new calycanthaceous alkaloid analogs were synthesized in excellent yields. The prepared compounds were evaluated for biol. activity against acetylcholinesterase and a broad range of plant pathogen fungi. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity than the pos. control. Notably, compounds I and II showed higher activity against Verticillium dahlia than chlorothalonil, with MIC values of 62.5 and 7.81μg mL^-1, resp. Compound III had a higher activity against Bacillus cereus, with a MIC value of 15.63μg mL^-1. Compounds IV and V revealed potent activity against acetylcholinesterase, with MIC values of 0.01 and 0.1 ng mL^-1, resp. Anal. of the mol. docking modes of IV and V with Torpedo californica acetylcholinesterase indicated a medium strong hydrogen bond interaction between the hydroxyl groups of both the ligands and the phenolic hydroxyl of Try121 at a distance of approx. 2.4 Å. The results obtained in this study will be useful for the further design and structural optimization of calycanthaceous alkaloids as potential agrochem. lead compounds for plant disease control. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, characterization and in vitro, in vivo and in silico antimicrobial and antiinflammatory activities of a new series of sulfonamide and carbamate derivatives of a nebivolol intermediate was written by Uma priya, K.;Venkataramaiah, Ch.;Sreedhar, N. Y.;Raju, C. Naga. And the article was included in RSC Advances in 2021.SDS of cas: 777-44-6 This article mentions the following:

A series of new sulfonamide and carbamate derivatives of Nebivolol drug intermediate (5) were designed and synthesized by reacting various biopotent sulfonylchlorides and chloroformates. The synthesized compounds are structurally characterized by spectral (IR, ¹H & ¹³C NMR and mass) and screened for their in vitro antimicrobial activity against four bacterial and three fungal strains, in vitro and in vivo antiinflammatory activity against LPS-induced inflammation in RAW 264.7, in vitro COX-1 and COX-2 inhibition potentiality, antagonistic profiles of carrageenan induced paw edema and cotton pellet induced granuloma in rat. Further, the compounds were screened for their antimicrobial and antiinflammatory activity against DNA gyrase A, COX-1 and COX-2 by using mol. docking approach. The bioactivity and toxicity risks were analyzed through Mol. Operating Environment. The results revealed that the compounds 8b, 8c, 8d, 8e, 8f, 8g and 9a exhibited the most promising antimicrobial activity against all the bacterial and fungal strains tested when compared with the standard drugs streptomycin and fluconazole. In view of in antiinflammatory activity, the compounds, 8b, 8c, 8d, 8e, 8f, 8g and 9a have shown potent antiinflammatory activity by inhibiting the LPS-induced inflammation in RAW 264.7 cell line, concentration dependent inhibition of COX-1 and COX-2, dose response dependent antagonism of carrageenan induced paw edema and granuloma tissue in rat. Mol. docking, ADMET and QSAR studies predicted that the recorded in silico profiles are in strong correlation with in vitro and in vivo antimicrobial and antiinflammatory results. In addition, the elevated toxicol. risks of the title compounds are identified with in the potential limits of drug candidates. Hence, it is suggested that the synthesized derivatives will stand as the promising antimicrobial and anti-inflammatory drug candidates in future. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

α_vβ₃ antagonists based on a central benzoic acid scaffold was written by Will, D. W.;Breipohl, G.;Gourvest, J.-F.;Ruxer, J.-M.;Doucet, B.;Auberval, M.;Baron, R.;Gaillard, M.;Gadek, T. R.;Knolle, J.;Stilz, H. U.;Peyman, A.. And the article was included in Polish Journal of Chemistry in 2005.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:

A series of highly potent α_vβ₃ antagonists, e.g., I, based on a benzoic acid scaffold and containing an acylguanidine as an Arg-mimetic and sulfonamide side chains is described. The compounds were selective against the fibrinogen receptor α_IIbβ₃ and they were capable of inhibiting bone resorption in vivo in a TPTX model of osteoporosis. Therefore the compounds were promising drug substances for the treatment of osteoporosis. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4-Butoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective synthesis of N,N-dimethyl aniline derivatives using dimethyl carbonate as a methylating agent and onium salt as a catalyst was written by Shivarkar, Anand B.;Gupte, Sunil P.;Chaudhari, Raghunath V.. And the article was included in Journal of Molecular Catalysis A: Chemical in 2005.COA of Formula: C8H10ClN This article mentions the following:

N-Alkylation of anilines by di-Me carbonate (DMC) catalyzed by onium salts has been demonstrated. The work shows that a simple catalytic system consisting of onium salts in the presence of a small amount of water is extremely effective in enhancing the DMC mediated N-alkylation of anilines to dialkylated products. The effect of reaction conditions, on the synthesis of N,N-di-methylaniline (NNDMA) from aniline and DMC has been investigated. Under the optimized conditions highest yield of NNDMA obtained was 99.8%, which is the best reported for liquid phase N-alkylation of aniline using DMC. The role of water in enhancing the yield of NNDMA is explained and a reaction-networking scheme is constructed, which summarizes the chem. behind liquid phase N-alkylation of anilines by DMC. The catalyst has been shown to recycle up to five times and at the end of fifth recycle almost 98% of NNDMA yields were obtained. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1COA of Formula: C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antifungal activity of novel 2-(1H-benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole derivatives was written by Ji, Zengchen;Liu, Feng;Zhang, Zeyuan;Li, Fubo;Jiang, Lin. And the article was included in Youji Huaxue in 2012.Synthetic Route of C7H3Cl2NS This article mentions the following:

Sixteen novel 2-(1H-benzimidazol-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles I(R = H, 4-F, 4-Cl, 4-Br, 2,4-Cl₂, 3,4-Cl₂, 4-Me, 4-MeO) and 2-(1H-benzimidazol-2-yl)-5-substituted phenylamino-1,3,4-oxadiazoles II(R = H, 4-F, 4-Cl, 4-Br, 2,4-Cl₂, 3,4-Cl₂, 4-Me, 4-MeO) were synthesized from benzimidazole-2-carboxylic acid, hydrazine hydrate, substituted Ph isothiocyanate and substituted benzoic acid by multi-step reactions. The target compounds were evaluated for their antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum, and the results indicated that three target compounds displayed excellent antifungal activities against Botrytis cinerea, with EC₅₀ values of 2.55, 6.34 and 5.12 μg/mL, resp., even higher than that of carbendazim. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics