Month: January 2023

Photochemical isomerization of metal ethene to metal vinyl hydride complexes: a matrix-isolation and solution NMR study was written by Bell, Tanachat W.;Haddleton, David M.;McCamley, Andrew;Partridge, Martin G.;Perutz, Robin N.;Willner, Helge. And the article was included in Journal of the American Chemical Society in 1990.Formula: C8H16Cl2Ir2 This article mentions the following:

CpRh(PMe₃)(C₂H₄) (I), CpIr(PMe₃)(C₂H₄) (II), and CpIr(C₂H₄)₂ (III) (Cp = η⁵-cyclopentadienyl) are isomerized on photolysis in argon matrixes at 12-20 K to metal vinyl hydride complexes CpM(L)(C₂H₃)H (L = PMe₃, C₂H₄). The products are identified by their characteristic metal hydride and vinyl group vibrations in the IR spectra and by the effect of ²H-labeling experiments The same products were generated by photolysis of I and III in a frozen toluene solution at 77 K or a cold toluene solution of II and characterized by ¹H, ¹³C, and ³¹P NMR. The vinyl hydride complexes exhibit a wide range of thermal stabilities isomerizing to their precursors at the following temperatures: CpRh(PMe₃)(C₂H₃)H at âˆ?53 K, CpIr(PMe₃)(C₂H₃)H at âˆ?93 K, CpIr(C₂H₄)(C₂H₃)H at âˆ?73 K. Photolysis of I in toluene solution at 188 K generates a mixture of CpRh(PMe₃)(C₂H₃)H and isomers of CpRh(PMe₃)(tolyl)H; at higher temperatures only insertion into toluene C-H bonds is observed Secondary photolysis of CpIr(C₂H₄)(C₂H₃)H in Ar matrixes causes ethene loss and formation of a product identified as the vinylidene complex CpIr(C:CH₂)H₂. Photolysis of III in CO and N₂ matrixes leads to substitution products CpIr(C₂H₄)L (L = CO, N₂), CpIr(CO)(C₂H₃)H, and CpIr(C₂H₄)(C₂H₃)H. Photolysis of I in CO matrixes generates CpRh(PMe₃)CO only; use of N₂ matrixes results in formation of CpRh(PMe₃)N₂ and CpRh(PMe₃)(C₂H₃)H. The photoproducts of II in CO matrixes are CpIr(PMe₃)(C₂H₃)H and CpIr(PMe₃)CO. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Formula: C8H16Cl2Ir2).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C8H16Cl2Ir2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactivity of N-chloro-substituted sulfonamides was written by Verma, Shiva M.;Srivastava, Ramesh C.. And the article was included in Indian Journal of Chemistry in 1966.Related Products of 14070-51-0 This article mentions the following:

The behavior of N-chloro-N-acyl- and N-chloro-N-aroyl-p-toluenesulfonamides in protonic and aprotic solvents was investigated. N-Acetyl- and N-benzoyl-p-toluenesulfonamides were prepared by acetylation (Ac2O and concentrated H2SO4) and benzoylation of p-MeC6H4SO2NH2, resp. N-Benzyl derivatives were obtained by the condensation of PhCH2NH2 with p-MeC6H4SO2Cl. The N-chloro derivatives were prepared by the action of excess HOCl on N-substituted p-toluenesulfonamides as described earlier (CA 63, 11421a); they could also be prepared by passing Cl into sodium salts of the parent sulfonamides. The following were prepared: N-chlorosaccharin, m. 152°: N-acetyl (benzyl and benzoyl)-N-chloro-p-toluenesulfonamides, m. 68°, 106°, and 96-8°, resp. All the N-chloro derivatives were crystalline compounds N-Chloro-N-acetyl derivatives in EtOH (with or without HCl) and in HOAc-H2SO4 media gave p-MeC6H4SO2NH2 and HOAc. The corresponding benzoyl derivatives in EtOH yielded the parent sulfonamide; in HOAc-H2SO4 medium the products formed were BzOH and p-MeC6H4SO2NH2. N-Chloro-N-benzoyl-p-toluenesulfonamide was stable toward these solvents. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Related Products of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of mono- and di-arylated acenaphthylenes and programmed access to dibenzo[j,l]fluoranthenes via palladium-catalysed C-H bond functionalisation was written by Shi, Xinzhe;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in Organic Chemistry Frontiers in 2018.Category: chlorides-buliding-blocks This article mentions the following:

C1-arylation and C1,C2-diarylation of acenaphthylenes via palladium-catalyzed direct arylation using either aryl bromides or benzenesulfonyl chlorides as aryl sources were reported. With aryl bromides, the mono-arylation was very selective, whereas with benzenesulfonyl chlorides C1,C2-diarylated acenaphthylenes were obtained in good yields. The reaction tolerated a wide variety of substituents including bromo or iodo. Moreover, the Pd-catalyzed intramol. C-H bond reaction of bromo-substituted C1,C2-diarylated acenaphthylenes provided the corresponding dibenzo[j,l]fluoranthenes. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enantioselective Synthesis of SM-130686 Based on the Development of Asymmetric Cu(I)F Catalysis To Access 2-Oxindoles Containing a Tetrasubstituted Carbon was written by Tomita, Daisuke;Yamatsugu, Kenzo;Kanai, Motomu;Shibasaki, Masakatsu. And the article was included in Journal of the American Chemical Society in 2009.Name: Chloromethyl benzoate This article mentions the following:

Two different catalytic enantioselective approaches to 3-aryl- and 3-alkenyl-3-hydroxy-2-oxindoles have been developed. First, enantioselective arylation and alkenylation reactions of isatins using aryltrimethoxysilanes and alkenyltrimethoxysilanes as nucleophiles can be catalyzed by a complex of CuF with structurally tuned Taniaphos in the presence of a catalytic amount of ZnF₂. Despite the wide substrate scope, this intermol. reaction was not applicable to a catalytic enantioselective synthesis of SM-130686 (I·HCl), a highly potent, orally active growth hormone secretagogue containing a sterically congested chiral tetrasubstituted carbon. Therefore, an intramol. catalytic enantioselective arylation of α-keto amides was developed, taking advantage of the robustness of arylboronate reagents under multiple synthetic conversions and silica gel column chromatog. purification A complex of CuF with Ph-BPE (II) catalyzed the enantioselective arylation of α-keto amide III, affording product IV in 85% ee. The addition of ZnF₂ to this intramol. reaction was not necessary. The first enantioselective synthesis of SM-130686 was achieved using this catalytic methodol. Because 2-oxyindoles are a versatile motif for biol. active compounds, the two types of Cu-catalyzed asym. reactions developed here will be useful for the synthesis of other natural products and pharmaceutical leads. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Name: Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives was written by Yu, Jia-Ying;Li, Xue-Qiang;Wei, Meng-Xue. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 1-Chlorooctadecane This article mentions the following:

Twelve derivatives of artemisinin-piperazine-dithiocarbamate, I (R = CH₂Ph, CH₂C₆H₄Me-4, n-pentyl, CH₂CO₂CH₂Ph, etc.), have been synthesized, and some of them show good in vitro cytotoxic activity. Compound I (R = CH₂C₆H₄CN-4) (II) exhibits the best inhibitory activity against SMMC-7721 cell lines with an IC₅₀ of 0.0025 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC₅₀ of 0.18 ± 0.04 μM for 72 h. The results indicate that compound II is more cytotoxic towards cancer cell lines than towards benign cell lines compared with vincristine in vitro. And compound II also has good inhibitory activity against colon, breast and prostate cancer cells. Meanwhile, we have also proposed the six-member ring mechanism of DMSO in catalyzing the esterification of hydroxyl and acyl chloride. Instead of using the hydroxyl, we can obtain the nucleophilic substitution production simply and efficiently without a Lewis acid, which has not been reported previously. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-catalyzed salt-free double decarboxylative aryl allylation was written by Daley, Ryan A.;Topczewski, Joseph J.. And the article was included in Organic & Biomolecular Chemistry in 2019.SDS of cas: 225104-76-7 This article mentions the following:

This report describes a palladium-catalyzed decarboxylative aryl allylation between unactivated benzoic acids and allylic carbonates. This transformation successfully couples a variety of carbonates and benzoic acids in good yield (up to 94%) using 1 mol% palladium. This salt free allyl-arylation proceeds without added base, copper, or silver. The only stoichiometric byproducts are carbon dioxide and tert-butanol. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7SDS of cas: 225104-76-7).

3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 225104-76-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Formylation of some sulfides of the furan series was written by Gol’dfarb, Ya. L.;Yakubov, A. P.;Belen’kii, L. I.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1965.Product Details of 3438-16-2 This article mentions the following:

Furfuryl chloride added at 5-10° to Me₃CSH in aqueous alc. KOH and kept 18 hrs. gave 87% α-furfuryl tert-Bu sulfide, b₈ 76-7°, n²⁰_D 1.5012, d₂₀ 0.9944; similarly prepared was 93% α-furfuryl phenyl sulfide, b_0.06 75-6°, 1.5960, 1.1414. Furfuryl mercaptan and PhCH₂Cl gave 89% benzyl α-furfuryl sulfide, b_0.9 111-12° n²⁰_D 1.5825, d₂₀ 1.1402. The products were treated in Me₂NCHO with POCl₃ at 0-20° 2.75 hrs. and after quenching in ice gave the following 5-alkyl(aryl)thiomethyl-2-furancarboxaldehydes (the R of the RS group in the compounds, b.p., n²⁰_D, and d₂₀ shown): Et, b_0.2 90-1°, 1.0575 (sic), 1.1538; iso-Pr, b_1.2 104-6°, 1.6558, 1.1119; Bu, b₂ 130-1°, 1.0550 (sic), 1.0937; Me₃C, b₂ 117° (m. 26-7.5°), -, -; Ph, b_0.1 132-40° (m. 24.5-5°), -, -; PhCH₂, b_0.1 145-6° (m. 35-6° ), -, -. The latter oxidized with Ag₂O to the corresponding carboxylic acid, m. 122-3°. The iso-Pr analog also gave the acid, m 95°. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Product Details of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient base-free hydrodehalogenation of organic halides catalyzed by a well-defined diphosphine-ruthenium(II) complex was written by Liu, Yahuan;Wang, Zheng;Zhao, Ziwei;Gao, Pengxiang;Ma, Ning;Liu, Qingbin. And the article was included in Molecular Catalysis in 2021.Application In Synthesis of 2-Chloro-N,N-dimethylaniline This article mentions the following:

A base-free, robust catalytic system based on the diphosphine-ruthenium(II) complex cation has been developed for the hydrodehalogenation of a wide range of aryl- and alkyl-chlorides/bromides (27 examples) with mol. hydrogen. Notably, the reaction proceeds at 120°C with low catalyst loading (0.1 mol%) and exhibits a good tolerance toward functional groups, such as amido, carboxyl, sulfonyl, methoxyl, ester groups. Moreover, a mechanism for the diphosphine-ruthenium(II) complex cation catalyzed dehalogenation process has been proposed. This hydrodehalogenation methodol. shows a potential application for the organic transformation and degradation of organic halides. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Application In Synthesis of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Total Synthesis of the Alleged Structure of Crenarchaeol Enables Structure Revision was written by Holzheimer, Mira;Sinninghe Damste, Jaap S.;Schouten, Stefan;Havenith, Remco W. A.;Cunha, Ana V.;Minnaard, Adriaan J.. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 76-83-5 This article mentions the following:

Crenarchaeol is a glycerol dialkyl glycerol tetraether lipid produced exclusively in Archaea of the phylum Thaumarchaeota. This membrane-spanning lipid is undoubtedly the structurally most sophisticated of all known archaeal lipids and an iconic mol. in organic geochem. The 66-membered macrocycle possesses a unique chem. structure featuring 22 mostly remote stereocenters, and a cyclohexane ring connected by a single bond to a cyclopentane ring. Herein, we report the first total synthesis of the proposed structure of crenarchaeol. Comparison with natural crenarchaeol allowed us to propose a revised structure of crenarchaeol, wherein one of the 22 stereocenters is inverted. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Recommanded Product: 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Determination of positional weighting factors for the Swain and Lupton substituent constants f and r was written by Williams, S. G.;Norrington, F. E.. And the article was included in Journal of the American Chemical Society in 1976.Product Details of 5344-49-0 This article mentions the following:

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Previous workers (Swain, C. G. and Lupton, E. C., 1968) have shown that Hammett’s substituent constant σ and related parameters can all be expressed as a linear combination of two principal components F and R, which represent resp. the field and resonance effects of the substituent without regard for its position in the mol. A statistical anal. of data from 45 reaction series was carried out to determine positional weighting factors f and r for F and R, to enable the latter to be applied to the ortho, meta, and para positions of a benzene ring simultaneously. The fpara and rpara were both defined as 1.000. Fmeta was 0.980 (not significantly different from 1.000), fortho 1.248, rmeta 0.347, and rortho 0.863. These values agree roughly with the ad hoc assumptions made hitherto by classical organic chemists and enable good correlations to be found between physicochem. properties of the side chain and substituent parameters of mixed or multiply substituted populations of benzenoid compounds They also demonstrate that generalized σ-type parameters may be successfully applied to the ortho position, although the correlation with observed data is less good than with the meta and para positions due, no doubt, to the proximity of the substituent to the side chain of the mol. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Product Details of 5344-49-0).

2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 5344-49-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics