Month: January 2023

K₂CO₃-Catalyzed Rapid Conversion of N-Sulfonylhydrazones to Sulfinates was written by Korawat, Harshita Singh;Basak, Ashok K.. And the article was included in ACS Omega in 2020.HPLC of Formula: 777-44-6 This article mentions the following:

N-Sulfonylhydrazones derived from alkyl, aryl, and heteroaryl aldehydes and ketones undergo rapid conversion into the corresponding sulfinates when heated with 10 mol % K₂CO₃ in N,N’-dimethylethylene urea (DMEU) at elevated temperature The reaction conditions are amenable to several functional groups and suitable for gram-scale synthesis. Under these base-catalyzed conditions, N-tosylhydrazones derived from O-allylated and O-propargylated 2-hydroxyarylaldehydes do not undergo the well-established intramol. [3 + 2]-cycloaddition reactions and generate corresponding sulfinates in good yields. The base-catalyzed transformation proceeds via crucial rapid intermol. protonation of the diazo intermediate to generate diazonium ion, which upon nucleophilic displacement by the sulfonyl ion provides the desired sulfinate selectively. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6HPLC of Formula: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Imidazolium Salt Catalyzed para-Selective Halogenation of Electron-Rich Arenes was written by Chen, Jie;Xiong, Xiaoyu;Chen, Zenghua;Huang, Jianhui. And the article was included in Synlett in 2015.Category: chlorides-buliding-blocks This article mentions the following:

A highly para-selective halogenation of arenes bearing coordinating groups in the presence of an imidazolium salt as a catalyst is reported. A series of electron-rich p-haloarenes were prepared in good yields and good to excellent selectivities. We also propose a plausible mechanism for the catalytic reaction. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Category: chlorides-buliding-blocks).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V₂ receptor agonists was written by Tsukamoto, Issei;Koshio, Hiroyuki;Akamatsu, Seijiro;Kuramochi, Takahiro;Saitoh, Chikashi;Yatsu, Takeyuki;Yanai-Inamura, Hiroko;Kitada, Chika;Yamamoto, Eisaku;Sakamoto, Shuichi;Tsukamoto, Shin-ichi. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Product Details of 85953-29-3 This article mentions the following:

The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V₂ receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V₂ receptor agonist. These studies provided the potent, orally active non-peptidic V₂ receptor agonists 10a and 10j. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Product Details of 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A sustainable natural clam shell derived photocatalyst for the effective adsorption and photodegradation of organic dyes was written by Qu, Ting;Yao, Xinxin;Owens, Gary;Gao, Liangjun;Zhang, Hailong. And the article was included in Scientific Reports in 2022.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

In response to an increasing desire for modern industries to be both green and sustainable, there has been increasing research focus on the reutilization of natural waste materials to effectively remove and degrade toxic wastewater effluents. One interesting food industry waste product is clam shell. Here a new photocatalytic nanomaterial derived from marine clam shells was successfully prepared and characterized. Thereafter the material was applied for the removal of two target dyes from aqueous solution, where the effect of both catalyst dose and initial dye concentration on adsorption and photocatalysis was investigated. The maximum adsorption capacities of methylene blue (100 mg/L) and Congo red (500 mg/L) were 123.45 mg/g and 679.91 mg/g, resp., where adsorption followed pseudo second order kinetics predominantly via a chem. adsorption process. The photodegradation removal efficiencies of the two dye solutions under visible light irradiation were 99.6% and 83.3% for MB and CR, resp. The excellent degradation performance in a mixed dye solution, with strong degradation capability and low cost, demonstrated that the clam shell catalyst material was a good candidate for practical field remediation of dye contaminated wastewater. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) was written by Niculescu-Duvaz, Dan;Gaulon, Catherine;Dijkstra, Harmen P.;Niculescu-Duvaz, Ion;Zambon, Alfonso;Menard, Delphine;Suijkerbuijk, Bart M. J. M.;Nourry, Arnaud;Davies, Lawrence;Manne, Helen;Friedlos, Frank;Ogilvie, Lesley;Hedley, Douglas;Whittaker, Steven;Kirk, Ruth;Gill, Adrian;Taylor, Richard D.;Raynaud, Florence I.;Moreno-Farre, Javier;Marais, Richard;Springer, Caroline J.. And the article was included in Journal of Medicinal Chemistry in 2009.SDS of cas: 6834-42-0 This article mentions the following:

BRAF is a serine/threonine kinase that is mutated in a range of cancers, including 50-70% of melanomas, and has been validated as a therapeutic target. The authors have designed and synthesized mutant BRAF inhibitors containing pyridoimidazolone as a new hinge-binding scaffold. Compounds have been obtained which have low nanomolar potency for mutant BRAF (12 nM for compound I) and low micromolar cellular potency against a mutant BRAF melanoma cell line, WM266.4. The series benefits from very low metabolism, and pharmacokinetics (PK) that can be modulated by methylation of the NH groups of the imidazolone, resulting in compounds with fewer H-donors and a better PK profile. These compounds have great potential in the treatment of mutant BRAF melanomas. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0SDS of cas: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting D-alanine-D-alanine ligase in bacterio was written by Ameryckx, Alice;Thabault, Leopold;Pochet, Lionel;Leimanis, Serge;Poupaert, Jacques H.;Wouters, Johan;Joris, Bernard;Van Bambeke, Francoise;Frederick, Raphael. And the article was included in European Journal of Medicinal Chemistry in 2018.Application of 6590-96-1 This article mentions the following:

A series of 1-(2-hydroxybenzoyl)thiosemicarbazides I [R¹ = H, 2-OH, 4-F, etc.; R² = Ph, 1-naphthyl, 3-pyridinyl, etc.] inhibitors of D-Ala-D-Ala ligase (Ddl) were designed and synthesized in order to target resistant strains of bacteria. Among these, compound I [R¹ = 2-OH, R² = 3,4-di-ClC₆H₃] was identified as a potent Ddl inhibitor with activity in the micromolar range. This compound, possessing strong antimicrobial activity including against multidrug resistant strains, was proven to act through a bactericidal mechanism and demonstrated very low cytotoxicity on THP-1 human monocytic cell line. Inhibition of Ddl activity by compound I compound I [R¹ = 2-OH, R² = 3,4-di-ClC₆H₃] was confirmed in-bacterio using UPLC-MS/MS by demonstrating an increase in D-Ala intracellular pools accompanied by a commensurate decrease in D-Ala-D-Ala. Further structure-activity relationships (SARs) studies provided evidence that the hydroxyl substituent in the 2-position (R1) of the benzoylthiosemicarbazide scaffold was essential for the enzymic inhibition. This work thus highlightened the 1-(2-hydroxybenzoyl)-thiosemicarbazide motif as a very promising tool for the development of novel antibacterial compounds acting through an interesting mechanism of action and low cytotoxicity. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Assessment of the effectiveness of onsite exsitu remediation by enhanced natural attenuation in the Niger Delta region, Nigeria was written by Okparanma, Reuben N.;Azuazu, Ikeabiama;Ayotamuno, Josiah M.. And the article was included in Journal of Environmental Management in 2017.SDS of cas: 3386-33-2 This article mentions the following:

This study was conducted to quantify and rank the effectiveness of onsite exsitu remediation by enhanced natural attenuation using soil quality index. The investigation was conducted at three oil spill sites in the Niger Delta (5.317°N, 6.467°E), Nigeria with a predominance of Oxisols. Baseline assessment and a two-step post-remediation monitoring of the sites were conducted. Target contaminants including total petroleum hydrocarbon (TPH) and BTEX (benzene, toluene, ethylbenzene, and xylene) were analyzed by gas chromatog.-mass spectrometry. Results of the baseline assessment showed that TPH concentrations across the study sites averaged between 5113 and 7640 mg/kg at 0- to 1-m depth, which was higher than the local regulatory value of 5000 mg/kg. The soil quality index across the sites ranged between 68 and 45, suggesting medium to high potential ecol. health risks with medium to high priority for remediation. BTEX concentrations followed a similar trend. However, after remediation TPH degraded rapidly initially and then slowly but asymptotically during the post-remediation monitoring period. Then, soil quality index across the study sites ranged between 100 and 58, indicating very low to medium potential ecol. health risks. This demonstrates the effectiveness of onsite exsitu remediation by enhanced natural attenuation as a remediation strategy for petroleum-contaminated soils, which holds great promise for the Niger Delta province. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2SDS of cas: 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.SDS of cas: 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of acyloxymethyl halides from acylals was written by Grynkiewicz, Grzegorz;Tsien, Roger Y.. And the article was included in Polish Journal of Chemistry in 1987.Recommanded Product: 5335-05-7 This article mentions the following:

Reaction of CH₂(OAc)₂ with Me₃SiBr in the presence of ZnCl₂ gave 81% AcOCH₂Br. Similarly, CH₂(OBz)₂ was treated with Me₃SiR (R = Br, Cl) and ZnCl₂ or AlCl₃ to give 50 and 21%, resp., of BzOCH₂R. In contrast, cleavage of MeOCH₂OAc with Me₃SiBr gave MeOCH₂Br and AcOIMe₃. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Recommanded Product: 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 4,5-Benzotropone π Complexes of Iron, Rhodium, and Iridium and Their Potential Use in Catalytic Borrowing-Hydrogen Reactions was written by Kodama, Takuya;Kawashima, Yuki;Deng, Zhirong;Tobisu, Mamoru. And the article was included in Inorganic Chemistry in 2021.Electric Literature of C8H16Cl2Ir2 This article mentions the following:

The syntheses of rhodium, iridium, and iron π complexes bearing 4,5-benzotropone ligands are reported. X-ray crystallog. analyses revealed that a tropone core coordinates to a metal center in a η⁴ manner with a tub-form geometry. Some of the benzotropone π complexes exhibited catalytic activity for N-alkylation of aniline by borrowing hydrogen. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Electric Literature of C8H16Cl2Ir2).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C8H16Cl2Ir2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Mediated Decarboxylative [3+2] Annulation of Ethynyl Benzoxazinanones and Benzimidamides: Synthesis of Imidazole Derivatives was written by Wang, Lan;Jiang, Feng;Gao, Xing;Wang, Wei;Wu, Yongjun;Guo, Hongchao;Zheng, Bing. And the article was included in Advanced Synthesis & Catalysis in 2021.Application of 18637-02-0 This article mentions the following:

A base-mediated decarboxylative [3+2] annulation of trimethylsilylethynyl benzoxazinanones I (R = H, 6-Me, 5-Cl, 8 -F, etc.; R¹ = H, trimethylsilyl) and benzimidamides hydrochloride R³C(=NH)NH₂•HCl (R³ = H, 2-methylphenyl, 3-chlorophenyl, 6-chloropyridin-3-yl, etc.) was achieved under mild reaction conditions to give various imidazole derivatives II (R⁴ = H, 4-Me, 3-Cl, 2-F, etc.) in high yields. Notably, it demonstrated a new reaction mode of alkynyl benzoxazinanones. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Application of 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics