Month: January 2023

Constructing semi-oriented single-walled carbon nanotubes artificial water channels for realized efficient desalination of nanocomposite RO membranes was written by Song, Xipeng;Li, Shuangshuang;Zhang, Wensheng;Liu, Hongpeng;Jiang, Jingyu;Zhang, Chunhua. And the article was included in Journal of Membrane Science in 2022.Recommanded Product: 4422-95-1 This article mentions the following:

The application of aquaporin-like structural materials in separation membranes has been developed for several years. Regretfully, the prepared nanocomposite reverse osmosis (RO) membranes exhibited an unsatisfactory separation performance. To obtain highly desirable applied indexes, here we report the use of chopped single-walled carbon nanotubes (SWNTs) with carboxylated ends to construct high-efficiency partially aligned artificial water channels via the “traction” action of external force. The factors affecting the separation performance of artificial water channels were emphatically explored by scientific experiments, demonstrating that only the carbon nanotubes (CNTs) are semi-oriented along the transmembrane direction can truly give play to the transport mechanism of the artificial water channel, thereby achieving high water permeance. Notably, the modification of the polydopamine (PDA) coating can provide phys. adhesion to make more SWNTs firmly adhere to the substrate surface, which improved the sieving ability of the SWNTs with a certain size range inner diameter and fortifying the structural stability between the substrate and the polyamide (PA) functional layer. The final PDA-PA-S RO membrane presented extraordinary separation performance with high water permeance of 3.88 L m^-2 h^-1 bar^-1 and salt rejection of 99.2%, which far surpasses that of the existing CNT-based and aquaporin-based RO membranes. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Surface modification of nanofiltration membranes to improve the removal of organic micropollutants: Linking membrane characteristics to solute transmission was written by Huang, Shiyang;McDonald, James A.;Kuchel, Rhiannon P.;Khan, Stuart J.;Leslie, Greg;Tang, Chuyang Y.;Mansouri, Jaleh;Fane, Anthony G.. And the article was included in Water Research in 2021.Electric Literature of C13H9Cl3N2O This article mentions the following:

Surface modification of nanofiltration (NF) membranes has great potential to improve the removal of organic micropollutants (OMs) by NF membranes. This study used polydopamine (PDA) as a model coating to comprehensively link the changes in membrane properties with the changes in transmission of 34 OMs. The membrane characterization demonstrated that a thicker, denser, and more hydrophilic PDA coating can be achieved by increasing the PDA deposition time from 0.5 to 4 h. Overall, the transmissions of target OMs were reduced by PDA-coated NF membranes compared to unmodified NF membranes. The neutral hydrophobic compounds showed lower transmissions for longer PDA coating (PDA4), while the neutral hydrophilic compounds tended to show lower transmissions for shorter PDA coating (PDA0.5). To explain this, competing effects provided by the PDA coatings are proposed including sealing defects, inducing cake-enhanced concentration polarization in the coating layer for neutral hydrophilic compounds, and weakened hydrophobic adsorption for neutral hydrophobic compounds For charged compounds, PDA4 with the greatest neg. charge among the PDA-coated membranes showed the lowest transmission. Depending on the mol. size and hydrophilicity of the compounds, the transmission of OMs by the PDA4 coating could be reduced by 70% with only a 26.4% decline in water permeance. The correlations and mechanistic insights provided by this work are highly useful for designing membranes with sp. surface properties via surface modification to improve the removal of OMs without compromising water production In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Electric Literature of C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iron doped activated carbon for effective removal of tartrazine and methylene blue dye from the aquatic systems: Kinetics, isotherms, thermodynamics and desorption studies was written by Joshiba, G. Janet;Kumar, P. Senthil;Rangasamy, Gayathri;Ngueagni, P. Tsopbou;Pooja, G.;Balji, G. Bharat;Alagumalai, Krishnapandi;El-Serehy, Hamed A.. And the article was included in Environmental Research in 2022.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

In the current research work, the activated carbon synthesized from the plant species Delonix regia is doped with iron oxide nanoparticles and enforced as a nanosorbent for the effective extermination of Tartrazine (TAR) and Methylene blue (MB) dyes. This nanosorbent is prepared from the bark powder of the Delonix regia and subjected to chem. activation; Furthermore, the synthesized biosorbent were characterized using FTIR, SEM, TGA, and XRD to understand their functional properties and structural morphol. The optimum effectiveness adsorption of Tartrazine and Methylene blue has been investigated by using different key parameters. The conclusions have shown the highest removal percentage at a pH of 3 and 6 for Tartrazine and Methylene blue, resp. For the various initial concentrations, the adsorption percentage reached equilibrium after 60 min and 90 min for TAR and MB. The adsorption equilibrium values were applied to various isotherms models. The adsorbent showed a higher removal capacity of 357.142 mg g^-1 and 147.058 mg g^-1 and for MB and TAR resp. The kinetic data were best fits to pseudo second order model. The thermodn. parameters indicated that this adsorption process was found to be spontaneous, exothermic and feasible at different temperatures These results have shown that the prepared adsorbent is an environmentally friendly and suitable material for the elimination of TAR and MB from water systems. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Basic metals. LXII. Preparation and reactions of the metal bases C₅H₅Ir(L)P(CHMe₂)₃ and C₅H₅IrL₂ (L = olefin) was written by Dziallas, M.;Hoehn, A.;Werner, H.. And the article was included in Journal of Organometallic Chemistry in 1987.Synthetic Route of C8H16Cl2Ir2 This article mentions the following:

The reaction of the chloro-bridged compounds [(olefin)₂IrCl]₂ (olefin = C₈H₁₄, C₂H₄, C₃H₆) with P(CHMe₂)₃ and LiC₅H₅ produces the half-sandwich type complexes, C₅H₅Ir(olefin)P(CHMe₂)₃ (I). For cyclooctene, the intermediate [(C₈H₁₄)[P(CHMe₂)₃]IrCl]₂ was isolated. I behave as metal bases and reacts with MeI to form C₅H₅IrCH₃[P(CHMe₂)₃]I (II). Subsequent reaction of II with NaBH₄ produces the hydrido(methyl)iridium complex C₅H₅IrCH₃[P(CHMe₂)₃]H. Protonation of I with HBF₄.OEt₂ leads to the formation of BF₄ salts of the cations [C₅H₅IrH(olefin)P(CHMe₂)₃]⁺. C₅H₅Ir(C₃H₆)P(CHMe₂)₃, obtained as two isomers, reacts with HBF₄.OEt₂ to give four isomers in a 73:16:7:4 ratio. Rotation of the olefin around the metal-olefin axes in I (olefin = C₂H₄, C₃H₆) can not be detected at room temperature The bis(olefin)iridium complexes, C₅H₅Ir(olefin)₂, which were prepared from [(olefin)₂IrCl]₂ and LiC₅H₅, also react with HBF₄.OEt₂ to give ionic products. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Synthetic Route of C8H16Cl2Ir2).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C8H16Cl2Ir2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anti-glycemic potential of benzophenone thio/semicarbazone derivatives: synthesis, enzyme inhibition and ligand docking studies was written by Arshia;Fayyaz, Sharmeen;Shaikh, Muniza;Khan, Khalid Mohammed;Choudhary, M. Iqbal. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Computed Properties of C7H3Cl2NS This article mentions the following:

Inhibition of dipeptidyl peptidase-IV (DPP-IV) has been identified as a promising approach for the treatment of type 2 diabetes mellitus (T2DM). Therefore, development of DPP-IV inhibitors with new chem. scaffold is of utmost importance to medicinal chem. In the present study, we identified benzophenone thio- and semicarbazone scaffolds as novel DPP-IV inhibitors. For that purpose, benzophenone thio- and semicarbazone were synthesized through a 2-step reaction. These newly synthetic derivatives were characterized by different spectroscopic techniques, including HREI-MS and NMR. whereas stereochem. of the iminic bond was predicted by NOESY experiments Thio- and semicarbazones derivatives were evaluated for their DPP-IV inhibitory potential and found to exhibit a good to moderate enzyme inhibitory activity. Most active and non-cytotoxic derivatives were further evaluated for their DPP-IV inhibitory potential in in cellulo model. The binding sites as well as affinity of active compounds for DPP- IV enzyme were predicted by in silico studies, and compared to a standard drug, sitagliptin. Pharmacophore studies of thio- and semicarbazones derivatives 1-29 suggest that substitution of aryl group, particularly a lipophilic substituents at C-4″ of benzene ring, and a hydroxyl at C-4â€?strongly influenced the DPP-IV inhibitory activity. Compound 9 showed the highest inhibitory activity (IC₅₀ = 15.0 ± 0.6 μM), whereas compounds 10, 17, 12, 14 and 23 showed a moderate activity with IC₅₀ values in the range of 28.9-39.2 μM. This study identifies thio- and semicarbazones as new classes of DPP-IV inhibitors which may translate into safe and effective therapeutics for a better management of type 2 diabetes.Communicated by Ramaswamy H. Sarma. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Crystal structures of salts and cocrystal of 1,3,5-triazine derivatives with thiophene carboxylic acid derivatives: an investigation on supramolecular interactions was written by Prajina, O. K.;Muthiah, P. T.;Perdih, F.. And the article was included in SN Applied Sciences in 2019.Reference of 36157-41-2 This article mentions the following:

Present work gives an account of different types of non covalent interactions encountered in the supramol. architectures of new salts and cocrystal formed between derivatives of 1,3,5-triazine and thiophene carboxylic acid. The novel salts formed between derivatives of thiophene carboxylic acid and 1,3,5-triazine are 2, 4-diamino-6-methyl-1,3,5-triazin-1-ium 5-carboxythiophene-2-carboxylate monohydrate, C₄H₈N₅⁺·C₆H₃O₄S₁^–·H₂O (I) and 2,4-diamino-6-methyl-1,3,5-triazin-1-ium 3-bromothiophene-2-carboxylate monohydrate, C₄H₈N₅⁺·C₅H₂O₂S₁Br₁^–·H₂O (II). The new cocrystal is a 1:1 cocrystal formed between 2,4-diamine-6-phenyl-1,3,5-triazine and 2,5-dichlorothiophene-3-carboxylic acid, C₉H₉N₅·C₅H₂O₂S₁Cl₂ (III). The newly synthesized salts (I and II) and cocrystal (III) have been characterized by single-crystal X-ray diffraction. Supramol. heterosynthons, homosynthons observed via N-H···O, N-H···N and O-H···N hydrogen bonds are also discussed. Anion···π interaction between carboxylate oxygen and aromatic rings of thiophene and triazine are observed in salt (I). π···π interaction is present between thiophene and triazine rings in salt (II). R²2(8) ring motif is formed in cocrystal (III) via N-H···O and O-H···N hydrogen bonds. Further stabilization of cocrystal (III) via Cl···O, Cl···Cl interactions as well as π···π interactions (triazine···triazine rings and triazine···phenyl rings) are also investigated. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Reference of 36157-41-2).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 36157-41-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library was written by Powell, Chelsea E.;Du, Guangyan;Che, Jianwei;He, Zhixiang;Donovan, Katherine A.;Yue, Hong;Wang, Eric S.;Nowak, Radoslaw P.;Zhang, Tinghu;Fischer, Eric S.;Gray, Nathanael S.. And the article was included in ACS Chemical Biology in 2020.Computed Properties of C8H8Cl2N4 This article mentions the following:

Cereblon (CRBN) is an E3 ligase adapter protein that can be reprogrammed by imide-class compounds such as thalidomide, lenalidomide, and pomalidomide to induce the degradation of neo-substrate proteins. In order to identify addnl. small mol. CRBN modulators, we implemented a focused combinatorial library approach where we fused an imide-based CRBN-binding pharmacophore to a heterocyclic scaffold, which could be further elaborated. We screened the library for CRBN-dependent antiproliferative activity in the multiple myeloma cell line MM1.S and identified five hit compounds Quant. chem. proteomics of hit compounds revealed that they induced selective degradation of GSPT1, a translation termination factor that is currently being explored as a therapeutic target for the treatment of acute myeloid leukemia. Mol. docking studies with CRBN and GSPT1 followed by analog synthesis identified a possible hydrogen bond interaction with the central pyrimidine ring as a mol. determinant of hit compounds’ selectivity. This study demonstrates that a focused combinatorial library design, phenotypic screening, and chem. proteomics can provide a suitable workflow to efficiently identify novel CRBN modulators. In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Computed Properties of C8H8Cl2N4).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C8H8Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Suppressing carboxylate nucleophilicity with inorganic salts enables selective electrocarboxylation without sacrificial anodes was written by Corbin, Nathan;Yang, Deng-Tao;Lazouski, Nikifar;Steinberg, Katherine;Manthiram, Karthish. And the article was included in Chemical Science in 2021.Related Products of 620-19-9 This article mentions the following:

Herein, a strategy to maintain selectivity without a sacrificial anode was developed by adding a salt with an inorganic cation that blocks nucleophilic reactions. Using anhydrous MgBr₂ as a low-cost, soluble source of Mg²⁺ cations, carboxylation of a variety of aliphatic, benzylic, and aromatic halides was achieved with moderate to good (34-78%) yields without a sacrificial anode. Moreover, the yields from the sacrificial-anode-free process were often comparable or better than those from a traditional sacrificial-anode process. Examining a wide variety of substrates showed a correlation between known nucleophilic susceptibilities of carbon-halide bonds and selectivity loss in the absence of a Mg2+ source. The carboxylate anion product was also discovered to mitigate cathodic passivation by insoluble carbonates produced as byproducts from concomitant CO₂ reduction to CO, although this protection can eventually become insufficient when sacrificial anodes were used. These results were a key step toward sustainable and practical carboxylation by providing an electrolyte design guideline to obviate the need for sacrificial anodes. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enantioselective Synthesis of Biaryl Atropisomers via Pd/Norbornene-Catalyzed Three-Component Cross-Couplings was written by Ding, Linlin;Sui, Xianwei;Gu, Zhenhua. And the article was included in ACS Catalysis in 2018.Quality Control of Chloromethyl benzoate This article mentions the following:

Three-component cross-coupling cocatalyzed by palladium and norbornene is reported for the synthesis of biaryl atropisomers, e.g., I. This domino reaction gave optimal yield and enantioselectivity with a P,C-type ligand bearing axial chirality and P chiral center. The process showed advantages over traditional cross-coupling because of its step economy and its compatibility with readily available ortho-substituted aryl halides, which could, therefore, be used instead of continuously trisubstituted aryl halides. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Quality Control of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rapid and ultrasensitive solution-based SERS detection of drug additives in aquaculture by using polystyrene sulfonate modified gold nanobipyramids was written by Amin, Muhammad Usman;Li, Lingwei;Zhang, Ruiyuan;Fang, Jixiang. And the article was included in Talanta in 2023.Application In Synthesis of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride This article mentions the following:

In recent years, surface-enhanced Raman spectroscopy (SERS) has been widely used in various fields for the rapid detection of trace-level mol. targets. In this study, we have developed a simple and effective solution-based SERS protocol to improve the activity for the detection of cationic dye mols. in aquaculture. The polystyrene sulfonate functionalized gold nanobipyramids (PSS-Au BPs) were synthesized from the cetyltrimethylammonium bromide (CTAB) reaction system followed by the ligand exchange process. The halide ions-induced aggregation of PSS-Au BPs was carried out by using four type of different salts such as NaCl, NaBr, MgCl₂ and MgSO₄ to investigate their influence on the SERS activity. The results demonstrate that the ionic strength of the solution has an important impact on the colloidal stability and SERS activity. The PSS-Au BPs show an improved SERS sensitivity at lower concentrations of the aggregating agents in solution-based SERS by detecting the crystal violet (CV) mols. with a limit of detection (LOD) to 3.28 x 10^-11 M. Furthermore, to demonstrate the generality of our proposed strategy, trace amounts of three more dyes such as malachite green (MG), methylene blue (MB), and rhodamine 6G (R-6G), as well as other mols. such as thiram and bisphenol-S were also detected. This protocol not only provides a method for rapid on-site detection of trace-level mols. but can also be applied to other SERS-based anal. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Application In Synthesis of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application In Synthesis of 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics