Month: January 2023

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I) was written by Liu, Yan;Haste, Nina M.;Thienphrapa, Wdee;Nizet, Victor;Hensler, Mary;Li, Rongshi. And the article was included in Marine Drugs in 2012.Application of 3438-16-2 This article mentions the following:

Infections caused by drug-resistant pathogens are on the rise. The ongoing spread of methicillin-resistant Staphylococcus aureus (MRSA) strains exemplifies the urgent need for new antibiotics. The marine natural product, marinopyrrole A, was previously shown to have potent antibiotic activity against Gram-pos. pathogens, including MRSA. However, its min. inhibitory concentration (MIC) against MRSA was increased by >500 fold in the presence of 20% human serum, thus greatly limiting therapeutic potential. Here we report our discovery of a novel derivative of marinopyrrole A, designated 1a, featuring a 2-4 fold improved MIC against MRSA and significantly less susceptibility to serum inhibition. Importantly, compound 1a displayed rapid and concentration-dependent killing of MRSA. Compared to the natural product counterpart, compound 1a provides an important natural product based scaffold for further Structure Activity Relationship (SAR) and optimization. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application of 3438-16-2).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 3438-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Can the NF membrane directly obtained by the interfacial polymerization of MPD and TMC? was written by Li, Lan-Qian;Tang, Yong-Jian;Xu, Zhen-Liang. And the article was included in Journal of Membrane Science in 2022.Synthetic Route of C9H3Cl3O3 This article mentions the following:

In the practical application of nanofiltration (NF) membrane, regular chem. cleaning is necessary to eliminate the membrane fouling and ensure the normal operation of the system. Generally, the com. NF membranes can be divided into MPD-TMC membranes and PIP-TMC membranes of which the permeability and pH resistance cannot be balanced. In this work, the ultra-low concentration monomers of MPD and TMC were used to fabricate the dense polyamide layer of NF membrane through a conventional interfacial polymerization reaction. The newly prepared membrane exhibited a smooth surface with very low roughness. Besides, the pore size distribution and desalination performance including water permeability and salt rejection of our membrane were comparable to the lab-made and com. PIP-TMC membranes. The membrane was also confirmed to have an excellent separation efficiency to SO^2-₄/Cl^– anions and good resistance to extreme pH conditions. Overall, this study presents a new insight for the preparation of high-performance NF membrane with good chem. stability. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Synthetic Route of C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper catalysed alkynylation of tertiary amines with CaC₂ via sp³ C-H activation was written by Teong, Siew Ping;Yu, Dingyi;Sum, Yin Ngai;Zhang, Yugen. And the article was included in Green Chemistry in 2016.HPLC of Formula: 698-01-1 This article mentions the following:

A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through catalytic cross-coupling of tertiary amines and calcium carbide was developed. The reaction proceeds via sp³ C-H bond activation and C-C coupling. Good to excellent yields were obtained for the corresponding propargylamines with both alkyl and aryl substitutions. The development of these functionalized propargylamines with a terminal alkyne group will offer a wider application for the synthesis of natural or pharmaceutical products due to their unique sp C-H reactivity. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1HPLC of Formula: 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of an accurate and sensitive analytical method for the determination of cadmium at trace levels using dispersive liquid-liquid microextraction based on the solidification of floating organic drops combined with slotted quartz tube flame atomic absorption spectrometry was written by Aydin, Ilgin;Chormey, Dotse Selali;Budak, Tuerkan;Firat, Merve;Turak, Fatma;Bakirdere, Sezgin. And the article was included in Journal of AOAC International in 2018.Synthetic Route of C18H37Cl This article mentions the following:

A dispersive liquid-liquidmicroextraction(DLLME) technique based on a solidification-of-floating-organic-drop (SFOD) procedure was developed for the determinationof trace amountsof cadmium (Cd) by using a flame at.absorption spectrometer (FAAS) fitted with a slotted quartz tube (SQT). The extractionof Cd was achieved by forming a complex with diphenylcarbazone. Parameters affecting the formation of complex and extractionoutputs were carefully optimized to obtain high-absorbance signals to achieve lower LODs. An SQT was fitted on top of the flame burner head to further enhance the absorbance of the signals recorded by the FAAS. Coupling the DLLME-SFOD procedure with SQT-FAAS produced an enhancement factor of about 183. The LOD of the method was 0.23μg/L with an RSD of 3.8%. Matrix-matching was used to overcome any low recovery results obtained with tap water and municipal wastewater. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Synthetic Route of C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents was written by Prasanna, D. S.;Kavitha, C. V.;Raghava, B.;Vinaya, K.;Ranganatha, S. R.;Raghavan, Sathees C.;Rangappa, K. S.. And the article was included in Investigational New Drugs in 2010.SDS of cas: 6590-96-1 This article mentions the following:

Benzothiazoles are multitarget agents with broad spectrum of biol. activity. Among the antitumor agents discovered in recent years, the identification of various 2-(4-aminophenyl) benzothiazoles as potent and selective antitumor drugs against different cancer cell lines has stimulated remarkable interest. Some of the benzothiazoles are known to induce cell cycle arrest, activation of caspases and interaction with DNA mol. Based on these interesting properties of benzothiazoles and to obtain new biol. active agents, a series of novel 4,5,6,7-tetrahydrobenzo[d]thiazole derivatives, e.g. I, were synthesized and evaluated for their efficacy as antileukemic agents in human leukemia cells (K562 and Reh). The chem. structures of the synthesized compounds were confirmed by ¹H NMR, LCMS and IR anal. The cytotoxicity of these compounds were determined using trypan blue exclusion, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Results showed that, these compounds mediate a significant cytotoxic response to cancer cell lines tested. It was found that the compounds having electron withdrawing groups at different positions of the Ph ring of the thiourea moiety displayed significant cytotoxic effect with IC₅₀ value less than 60 μM. To rationalize the role of electron withdrawing group in the induction of cytotoxicity, I (IC₅₀ âˆ?5 μM) which is having chloro substitution at ortho and para positions was chosen . Flow cytometric anal. of annexin V-FITC/ propidium iodide (PI) double staining and DNA fragmentation suggest that I can induce apoptosis. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1SDS of cas: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors was written by Almstead, Neil G.;Bradley, Rimma S.;Pikul, Stanislaw;De, Biswanath;Natchus, Michael G.;Taiwo, Yetunde O.;Gu, Fei;Williams, Lisa E.;Hynd, Barbara A.;Janusz, Michael J.;Dunaway, C. Michelle;Mieling, Glen E.. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 1138-56-3 This article mentions the following:

The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based matrix metalloproteinase (MMP) inhibitors are described. The thiazine- and thiazepine-based inhibitors were discovered by optimization of hetererocyclic sulfonamide-based inhibitors. The most potent series of inhibitors was obtained by modification of the amino acid D-penicillamine. This amino acid provides a gem-di-Me group on the thiazine or thiazepine ring which has a dramatic effect on the in vitro potency of this series. In particular, the sulfide I [n = 0] and the sulfone I [n = 2] were potent, broad-spectrum inhibitors of the MMPs with IC₅₀‘s against MMP-1 of 0.8 and 1.9 nM, resp. The binding mode of this novel thiazepine-based series of MMP inhibitors was established based on X-ray crystallog. of the complex of stromelysin and I [n = 0]. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3HPLC of Formula: 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzosuberane-5,8-diones was written by McKay, Roslyn;Proctor, George R.. And the article was included in Journal of Chemical Research, Synopses in 1996.Related Products of 6834-42-0 This article mentions the following:

Oxazolone intermediates were prepared from valine derivatives and converted into 3-methoxy-γ-methyl-γ-oxobenzenepentanoic acid and 3-methoxy-γ-oxobenzenepentanoic acid, resp. The cyclocondensation of these compounds gave the desired benzosuberones i.e., 3-methoxy-5-methyl-5H-benzocyclohepten-6,9-dione 3-methoxy-5H-benzocyclohepten-6,9-dione. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Related Products of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo was written by Fu, Dong-Jun;Song, Jian;Zhu, Ting;Pang, Xiao-Jing;Wang, Sheng-Hui;Zhang, Yan-Bing;Wu, Bo-Wen;Wang, Jun-Wei;Zi, Xiaolin;Zhang, Sai-Yang;Liu, Hong-Min. And the article was included in European Journal of Medicinal Chemistry in 2020.Computed Properties of C9H9ClO2 This article mentions the following:

NEDDylation pathway regulates multiple physiol. process, unlike inhibitors, NEDDylation activators are rarely studied. Novel amide derivatives were synthesized and evaluated for antiproliferative activity against MGC803, MCF-7 and PC-3 cells. Among them, VII-31 displayed the most potent activity with an IC₅₀ value of 94 nmol/L against MGC803 cells. Cellular mechanisms elucidated that VII-31 inhibited the cell viability, arrested cell cycle at G2/M phase and induced apoptosis via intrinsic and extrinsic pathways against MGC803 cells. In addition, VII-31 activated NAE1-Ubc12-Cullin1 NEDDylation via interacting with NAE1 directly. Furthermore, the activation of NEDDylation resulted in the degradation of inhibitor of apoptosis proteins (IAPs). Importantly, VII-31 inhibited tumor growth in xenograft models in vivo without the apparent toxicity. In summary, it is the first time to reveal that VII-31 deserves consideration for cancer therapy as a NEDDylation activator. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Computed Properties of C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boiling water-catalyzed neutral and selective N-Boc deprotection was written by Wang, Jia;Liang, Yan-Liang;Qu, Jin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.COA of Formula: C11H14ClNO2 This article mentions the following:

A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6COA of Formula: C11H14ClNO2).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C11H14ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors was written by Sun, Ying;Shan, Yuanyuan;Li, Chuansheng;Si, Ru;Pan, Xiaoyan;Wang, Binghe;Zhang, Jie. And the article was included in European Journal of Medicinal Chemistry in 2017.Safety of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, the authors designed and prepared three classes of multi-target inhibitors based on the extensive sequence homol. along the kinase domain of angiogenic RTKs. Biol. evaluation indicated that these multi-target inhibitors exhibited considerable potential as novel anti-angiogenic and anticancer agents. Among them, a diaryl thiourea bearing 1H-indazole-3-amine (16a, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N’-[5-bromo-2-(trifluoromethoxy)phenyl]thiourea) displayed the most potent RTK inhibition and excellent selectivity. It also showed inhibition on viability of human umbilical vein endothelial cells and anti-proliferation against a broad spectrum of cancer cells. Therefore, 1H-indazole-3-amine could serve as a promising hinge binding group for multi-target inhibitors of VEGFR-2, Tie-2, and EphB4. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Safety of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics