Month: January 2023

Synthesis of 1-aryl- and 1-alkyl-2,3-dimethylquinoxalinium perchlorates. 2. Synthesis and proton NMR spectra of 2,3-dimethyl-1-phenyl-6-X-quinoxalinium perchlorates was written by Schelz, Dieter. And the article was included in Helvetica Chimica Acta in 1978.Quality Control of Ethyl 4-chloro-3-nitrobenzoate This article mentions the following:

A general method for the preparation of the title compounds I (X = CH, R = Ph, R¹ = NO₂, SO₂Me, CN, CF₃, CO₂Et, Cl, Br, Me, OMe; R = Me, 4-ClC₆H₄, R¹ = NO₂, H, X = CH; R = Ph, R¹ = H, X = N) involved the condensation of 4,2-R(H₂N)C₆H₃NHR with MeCOCOMe and HClO₄ in a mixed solvent containing excess Et₂O. I were converted into II by heating with Et₃N and Me₂CO. The NMR shifts of I were correlated with Hammet’s constant σ_p. I are useful as dye precursors. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Quality Control of Ethyl 4-chloro-3-nitrobenzoate).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of Ethyl 4-chloro-3-nitrobenzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acyloxymethyl as a drug protecting group. Synthesis and reactivity of N-(acyloxymethyl)sulfonamide prodrugs was written by Calheiros, Teresa;Iley, Jim;Lopes, Francisca;Moreira, Rui. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1995.Application In Synthesis of Chloromethyl benzoate This article mentions the following:

Tertiary N-(acyloxymethyl)sulfonamide prodrugs R¹SO₂NR²CH₂OCOR³ (R¹ = 4-MeC₆H₄, 4-ClC₆H₄, 4-O₂NC₆H₄, 4-H₂NC₆H₄, R² = Me, Et, Pr CHMe₂, Bu, Q, Q¹, R³ = Ph, CMe₃, Q²), encompassing penicillin and sulfonamide antibiotics, have been synthesized. The pH-independent hydrolysis of these compounds occurs via the rate-determining formation of an N-sulfonyl iminium ion. SCF-MO calculations using the PM3 method indicate that iminium ion formation is slightly favored, when compared with the corresponding amides, by ca. 10 kJmol^-1. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application In Synthesis of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study was written by Abdel-Aziz, Alaa A.-M.;Asiri, Yousif A.;Al-Agamy, Mohamed H. M.. And the article was included in European Journal of Medicinal Chemistry in 2011.Related Products of 63624-28-2 This article mentions the following:

Here in, we report the design, synthesis, and antibacterial activity of series of bulky arenesulfonamido derivatives using ciprofloxacin and norfloxacin as scaffolds. All the synthesized compounds were investigated in vitro for their antibacterial activities against two Gram-pos. and two Gram-neg. organisms using dilution broth method. Some of the synthetic compounds showed significance difference from the standard drug ciprofloxacin. 2D-QSAR study provides details on the fine relationship linking structure and activity and offers clues for structural modifications that can improve the activity. Docking study of the compound I into the active site of the topoisomerase II DNA-gyrase enzymes revealed a similar binding mode to ciprofloxacin with addnl. classical and nonclassical hydrogen bonds. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Related Products of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A facile total synthesis of estrogens was written by Daniewski, Andrzej Robert;Kiegiel, Jaroslaw. And the article was included in Journal of Organic Chemistry in 1988.Application of 6834-42-0 This article mentions the following:

Indandione I, obtained by the stereoselective addition of 3-MeOC₆H₄CH₂CHO to 5,6,7,7a-tetrahydro-7a-methyl-1,5-indandione, was transformed into 3-Me ethers of equilenin, 7-hydroxyequilenin, and 9(11)-dehydroestrone, as well as its 7β and 7α hydroxy derivatives II. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Late 3d-Transition Metal Complexes Bearing a Bis-Phosphine Borane Ligand, PhB(CH₂P^tBu₂)₂ was written by Handford, Rex C.;Zhong, Lingfei;Tilley, T. Don. And the article was included in Organometallics in 2022.Name: (Chloromethanetriyl)tribenzene This article mentions the following:

The coordination chem. of a bidentate ambiphilic ligand, PhB(CH₂P^tBu₂)₂ ([BP₂^tBu]), is established for a series of Co, Ni, and Cu compounds The chloride starting materials [BP₂^tBu]MCl₂ [M = Co (1_Co), Ni (1_Ni)] and [BP₂^tBu]CuCl (2_Cu) are readily accessed in high yields by the treatment of the corresponding metal chloride salts with [BP₂^tBu] in THF solution The reduction of 1_Ni to [BP₂^tBu]NiCl (2_Ni) was affected by treatment with KC₈. In contrast, the corresponding Co^I species was not isolable under similar reaction conditions. However, monovalent mesityl complexes of the form [BP₂^tBu]M(Mes) [M = Co (3_Co), Ni (3_Ni), Cu (3_Cu)] were prepared by the treatment of 1_Co with one equiv of Mes₂Mg(THF)₂ or by the reaction of 2_M (M = Ni, Cu) with 0.5 equiv of Mes₂Mg(THF)₂. Modification of the borane moiety in 2_Ni was explored by the treatment of this complex with 4-dimethylaminopyridine (DMAP) to produce [PhB(DMAP)(CH₂P^tBu₂)₂]NiCl (4), which displays distinct features in its UV-visible spectrum compared to 2_Ni. The solid-state mol. structures of most complexes have been determined by single-crystal X-ray diffraction anal. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Name: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of quinolines via ortho-lithiated N-acylanilines. A modified Friedlaender synthesis was written by Cho, In Seop;Gong, Leyi;Muchowski, Joseph M.. And the article was included in Journal of Organic Chemistry in 1991.Quality Control of tert-Butyl (4-chlorophenyl)carbamate This article mentions the following:

A new variation of the Friedlaender quinoline synthesis was devised based on the sequential reaction of ortho-lithiated N–tert-Boc-anilines or N-pivaloylanilines with masked malondialdehyde derivatives, e.g., vinamidinium salts I (R = H, Ph), 3-(dimethylamino)acrolein, and 3-ethoxymethacrolein, and subsequent acid-induced cyclization. Thus, anilines II (R¹ = H, F, Cl, Me, OMe, R² = OCMe₃) were lithiated and cyclized with I (R = H) to give quinolines III. Lithiation of II (R¹ = F, R² = CMe₃) and cyclization with EtOCH:CMeCHO gave III (R¹ = F, R = Me). In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Quality Control of tert-Butyl (4-chlorophenyl)carbamate).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of tert-Butyl (4-chlorophenyl)carbamate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and in vitro anti-Helicobacter pylori activity of 2-(substituted benzylthio)-5-(5-nitro-2-furyl)-1,3,4-thiadiazole derivatives was written by Mohammadhosseini, Negar;Asadipour, Ali;Letafat, Bahram;Vosooghi, Mohsen;Siavoshi, Farideh;Shafiee, Abbas;Foroumadi, Alireza. And the article was included in Turkish Journal of Chemistry in 2009.Product Details of 697-73-4 This article mentions the following:

Starting from (5-nitrofuran-2-yl)methylene diacetate, a series of 2-[(substituted benzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles were synthesized and characterized. The in vitro anti-Helicobacter pylori activity of the synthesized compounds was evaluated by the disk diffusion method against the clin. isolates of Helicobacter pylori. The results indicated that most of the synthesized compounds exhibited significant inhibitory activity against H. pylori with respect to standard drug metronidazole. Compound I, containing the 2-chloro-6-fluorobenzylthio moiety, was the most potent compound tested. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Product Details of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effect of fluorine substitution of α- and β-hydrogen atoms in ethyl phenylacetate and phenylpropionate on their stereoselective hydrolysis by cultured cancer cells was written by Yamazaki, Yoshimitsu;Yusa, Shiro;Kageyama, Yu-ichi;Tsue, Hirohito;Hirao, Ken-ichi;Okuno, Hiroaki. And the article was included in Journal of Fluorine Chemistry in 1996.Recommanded Product: 7476-66-6 This article mentions the following:

(±)-Et 2-fluoro-2-phenylacetate was stereoselectively hydrolyzed by cultured cells of several rat cancer cell lines to give the carboxylic acid rich in the R enantiomer. The stereoselectivity increased for (±)-Et 2-fluoro-2-phenylpropionate (I) with all present cell lines and for (±)-Et 2-phenyl-3,3,3-trifluoropropionate with rat hepatoma McA-RH7777 cell line. The stereoselectivity was different for the different cell lines, as McA-RH7777 cells preferred (R)-I in contrast with the preference towards (S)-I by other cells such as ras oncogene-transformed rat liver Anr4 cells. These stereoselectivities were different from those for non-fluorinated (±)-Et 2-phenylpropionate. Thus fluorine atoms are recognized by ester hydrolases of cancer cells, and fluorine substitution on the acyl group will be useful for making ester-type anticancer prodrugs more specific to cancer cells. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Recommanded Product: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship of aloperine derivatives as new anti-liver fibrogenic agents was written by Wang, Kun;Guo, Zhihao;Bao, Yunyang;Pang, Yudong;Li, Yinghong;He, Hongwei;Song, Danqing. And the article was included in Molecules in 2020.Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Novel 12N-substituted aloperine derivatives I [R = Et, 3,4,5-trimethylphenyl, oxan-4-yl, etc.; R¹ = H, Me, naphthalen-2-yl; RR¹ = -(CH₂)₄-] and 12N-N’-phenoxazinylcarbamoylmethyl aloperine, II [R² = naphthalen-1-yl, 3-(trifluoromethyl)phenyl, Ph, 4-bromo-3-(trifluoromethyl)phenyl], III [R² = Bu, 3-(trifluoromethoxy)phenyl, 3-bromophenyl, etc.]were synthesized and investigated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells, taking aloperine (1) as the hit. A structure-activity relationship (SAR) study disclosed that the introduction of suitable substituents on the 12N atom might enhance the activity. Compound 12N-N’-phenoxazinylcarbamoylmethyl aloperine exhibited a good promise on down-regulating COL1A1 expression with the IC₅₀ value of 16.5μM. Its inhibitory activity against COL1A1 was further confirmed on both mRNA and protein levels. Meanwhile, it effectively inhibited the expression of other fibrogenic proteins, such as transforming growth factor β1 (TGF-α1) and smooth muscle actin (α-SMA). It also exhibited good in vivo safety profile with the oral LD₅₀ value of 400 mg kg^-1 in mice. The results initiated the anti-liver fibrogenic study of aloperine derivatives, and the key compound 12N-N’-phenoxazinylcarbamoylmethyl aloperine was selected as a novel lead for further investigation against liver fibrogenesis. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A General Synthesis of N-Hydroxyindoles was written by Wong, Audrey;Kuethe, Jeffrey T.;Davies, Ian W.. And the article was included in Journal of Organic Chemistry in 2003.Recommanded Product: 16588-16-2 This article mentions the following:

A general method for the formation of N-hydroxyindoles is demonstrated through a Pb-promoted intramol. reductive cyclization of o-nitrobenzyl ketones and aldehydes under transfer hydrogenation conditions. The N-hydroxyindoles are isolated in high purity and excellent yield (>90%) in an operationally simple procedure. This new method is exemplified by a two-step synthesis of the naturally occurring 1-methoxyindole-3-carboxaldehyde, which is pivotal in many alkaloid total syntheses. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics