Month: January 2023

Preparations of chloro(diene)polyfluorophenylplatinum(II) complexes and the structure of chloro(dicyclopentadiene)pentafluorophenylplatinum(II) was written by Deacon, G. B.;Gatehouse, B. M.;Nelson-Reed, K. T.. And the article was included in Journal of Organometallic Chemistry in 1989.HPLC of Formula: 12083-92-0 This article mentions the following:

The complexes, PtCl(diene)R [diene = hexa-1,5-diene (hex), norbornadiene (nbd), R = C₆F₅, p-HC₆F₄, p-MeOC₆F₄; diene = dicyclopentadiene (dcy), R = C₆F₅] have been prepared by reaction between equimolar amounts of PtCl₂(diene) and Me₃SnR in CH₂Cl₂. Most reactions also gave some of the corresponding PtR₂(diene) complex, which was readily separated by chromatog., and Pt(p-MeOC₆F₄)₂(nbd) was obtained in high yield from PtCl₂(nbd) and Me₃Sn(p-MeOC₆F₄) when a 1:2 mol ratio was used. Attempts to prepare PtCl(dcy)R (R = p-HC₆F₄, p-MeOC₆F₄) from Me₃SnR gave only PtR₂(dcy) in boiling CH₂Cl₂ despite the use of 1:1 reactant stoichiometry, and Pt(p-MeOC₆F₄)₂(dcy) or no reaction (R = p-HC₆F₄) at room temperature Alternative reagents, R’₃SnR (R’ = Bu, Et; R = C₆F₅, p-MeOC₆F₄) had a variable effect on the selectivity of monoarylation. Thus, Bu₃SnC₆F₅ was more selective and Et₃SnC₆F₅ less selective in formation of PtCl(hex)C₆F₅ than Me₃SnC₆F₅. With Et₃SnR (R = C₆F₅, p-MeOC₆F₄) and an equimolar amount of PtCl₂(dcy), PtCl(dcy)R was the major product. The crystal structure of PtCl(dcy)C₆F₅ shows near square planar stereochem. for platinum and steric congestion. The double bond from the six-membered ring of dcy is unsym. coordinated to platinum trans to C₆F₅ and is further from the metal than the other double bond, which is sym. bonded trans to chlorine. The pentafluorophenyl group is approx. normal to the coordination plane, and gives two o-fluorine resonances in the ¹⁹F NMR spectrum. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0HPLC of Formula: 12083-92-0).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 12083-92-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Silver-Catalyzed C(sp3)-H Sulfonylation for the Synthesis of Benzyl Sulfones Using Toluene Derivatives and α-Amino Acid Sulfonamides was written by Kanyiva, Kyalo Stephen;Uchida, Kanako;Shibata, Takanori. And the article was included in Bulletin of the Chemical Society of Japan in 2021.Category: chlorides-buliding-blocks This article mentions the following:

We describe a simple and practical protocol for the synthesis of benzyl sulfones using readily available toluene derivatives and α-amino acid sulfonamides. The reaction proceeds to afford a broad range of benzyl sulfones in moderate to high yields under silver catalysis. The mechanism possibly involves a Minisci-type formation of α-aminoalkyl radical, homolytic cleavage of a N-S bond to generate a sulfonyl radical, and coupling of sulfonyl radical with a benzyl radical formed via hydrogen abstraction by sulfate anion radical. The practicality of the present reaction is demonstrated by a gram-scale synthesis and one-step synthesis of anticancer-active compound The mechanism studies are conducted using radical scavengers and deuterated toluene. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Category: chlorides-buliding-blocks).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors was written by Yu, Zhiliang;Zhuang, Chunlin;Wu, Yuelin;Guo, Zizhao;Li, Jin;Dong, Guoqiang;Yao, Jianzhong;Sheng, Chunquan;Miao, Zhenyuan;Zhang, Wannian. And the article was included in International Journal of Molecular Sciences in 2014.COA of Formula: C7H5ClF2 This article mentions the following:

A series of sulfamide I (R₁ = HCCCH₂, 3-FC₆H₄CH₂, NCCH₂, 2,6-F₂C₆H₃CH₂, C₆H₅CH₂; R₂ = HCCCH₂, H₂C:C:CH, H) and triazole benzodiazepines, e.g. II, were obtained with the principle of bioisosterism. The p53-murine double minute 2 (MDM2) inhibitory activity and in vitro antitumor activity were evaluated. Most of the benzodiazepines exhibited moderate protein binding inhibitory activity. The triazole benzodiazepines showed good inhibitory activity and antitumor potency. The compound 8-chloro-4-(4-chloro-phenyl)-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene had promising antitumor activity against the U-2 OS human osteosarcoma cell line with an IC₅₀ value of 4.17 μM, which was much better than that of nutlin-3. The mol. docking model also successfully predicted that this class of compounds mimicked the three critical residues of p53 binding to MDM2. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-catalyzed reductive desulfonative aminocarbonylation of benzylsulfonyl chlorides with nitroarenes towards arylacetamides was written by Liu, Yongzhu;Bao, Zhi-Peng;Qi, Xinxin;Wu, Xiao-Feng. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

A new palladium-catalyzed reductive desulfonative aminocarbonylation reaction with benzylsulfonyl chlorides RCH₂S(O)₂Cl (R = Ph, 3,4-dimethylphenyl, 2,4-dichlorophenyl, etc.) as C(sp³) electrophiles has been developed. Using nitroarenes R¹NO₂ (R¹ = Ph, quinolin-8-yl, 2H-1,3-benzodioxol-5-yl, etc.) as readily accessible and stable nitrogen surrogates, a wide range of arylacetamides RCH₂C(O)NHR¹ were easily prepared in high yields with very good functional group compatibility. Mo(CO)₆ plays a dual role as both a CO source and reductant. Moreover, a late-stage modification of natural products was also achieved via this aminocarbonylation strategy. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of Oxidation of 4-Oxoacids by N-Chlorosaccharin in Aqueous Acetic Acid Medium was written by Farook, N. A. Mohamed. And the article was included in Journal of Solution Chemistry in 2007.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

The oxidation kinetics of substituted and unsubstituted 4-oxoacids (S) by N-chlorosaccharin (NCSA) have been studied in aqueous acetic acid media. The reaction follows first-order kinetics in each of the 4-oxoacids, NCSA and H⁺. The effect of changes in the electronic nature of the substrate reveals that pos. charge develops in the transition state. Based on the kinetic results and product anal., a suitable mechanism has been proposed for the reaction of NCSA with 4-oxoacids. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Borylfuroxans: Synthesis and Applications was written by Xie, Weibin;Hayashi, Masahiko;Matsubara, Ryosuke. And the article was included in Organic Letters in 2021.COA of Formula: C19H15Cl This article mentions the following:

Herein the authors report the 1st synthesis of borylfuroxans via the reaction of sulfonylfuroxans with Lewis base-ligated boranes under radical conditions. As a synthetic application, the transformation of borylfuroxans to a range of 1,2-dioximes and their derivatives is demonstrated. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children′s Health Exposure Analysis Resource laboratory network was written by Kannan, Kurunthachalam;Stathis, Alexa;Mazzella, Matthew J.;Andra, Syam S.;Barr, Dana Boyd;Hecht, Stephen S.;Merrill, Lori S.;Galusha, Aubrey L.;Parsons, Patrick J.. And the article was included in International Journal of Hygiene and Environmental Health in 2021.HPLC of Formula: 101-20-2 This article mentions the following:

A consortium of laboratories established under the Children′s Health Exposure Anal. Resource (CHEAR) used a multifaceted quality assurance program to promote measurement harmonization for trace organics analyses of human biospecimens that included: (1) participation in external quality assurance (EQA)/proficiency testing (PT) programs; (2) analyses of a urine-based CHEAR common quality control (QC) pool with each anal. batch across all participating laboratories; (3) method validation against NIST Standard Reference Materials (SRMs); and (4) analyses of blinded duplicates and other project-specific QC samples. The capability of five CHEAR laboratories in organic chem. anal. increased across the 4-yr period, and performance in the external PT program improved over time – recent challenges reporting >90% analytes with satisfactory performance. The CHEAR QC pools were analyzed for several classes of organic chems. including phthalate metabolites and environmental phenols by the participating laboratories with every batch of project samples, which provided a rich source of measurement data for the assessment of intra- and inter-laboratory variance. Within-laboratory and overall variabilities in measurements across laboratories were calculated for target chems. in urine QC pools; the coefficient of variation (CV) was generally below 25% across batches, studies and laboratories and indicated acceptable anal. imprecision. The suite of organic chems. analyzed in the CHEAR QC pool was broader than those reported for com. available reference materials. The accuracy of each of the laboratories methods was verified through the anal. of several NIST SRMs and was, for example, 97 ± 5.2% for environmental phenols and 95 ± 11% for phthalates. Anal. of blinded duplicate samples showed excellent agreement and reliability of measurements. The intra-class correlation coefficients (ICC) for phthalate metabolites analyzed in various batches across three CHEAR laboratories showed excellent reliability (typically >0.90). Overall, the multifaceted quality assurance protocols followed among the CHEAR laboratories ensured reliable and reproducible data quality for several classes of organic chems. Increased participation in external PT programs through inclusion of addnl. target analytes will further enhance the confidence in data quality. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2HPLC of Formula: 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rh^I, Ir^III ,and Co^III Complexes with Atropchiral Biaryl Cyclopentadienyl Ligands: Syntheses, Structures, and Catalytic Activities was written by Duchemin, Coralie;Smits, Gints;Cramer, Nicolai. And the article was included in Organometallics in 2019.Name: Chlorobis(ethylene)iridium(I) dimer This article mentions the following:

Chiral cyclopentadienyl (Cp^x) group 9 metal complexes have become versatile catalysts for a variety of efficient enantioselective C-H functionalizations. Atropchiral binaphthyl-derived Cp^x ligands and their complexes I (M = Rh; L₁L₂ = COD, X absent; M = Co, L¹, X = I, L² = CO; M = 1/2 Ir, L¹, X = I, L² absent) having tuning options at the 3,3′-positions (R¹ = halo, silyl, OMe; R²R³ = benzo or R² = OMe, R³ = H) present a robust choice of catalyst, giving high enantioselectivities and good reactivities. Herein, we report streamlined syntheses of binaphthyl backbone Cp^x ligands that feature new substituents at the 3,3′-positions: namely, trimethylsilyl, I, and Br. We introduce as well Cp^x ligands with a new atropchiral MeO-biphenyl backbone. All ligands are smoothly complexed with rhodium(I) salts. The Cp^xRh^I complexes obtained were systematically mapped by X-ray crystal anal. in order to collect steric parameters that might guide a rational selection of the chiral Cp^x ligand for enantioselective reactions. The catalytic performances of the complexes were evaluated by two Rh^III-catalyzed C-H functionalizations as benchmark transformations. In both cases, a simpler to access ligand provided superior reactivity and enantioselectivity. Addnl., related Cp^xCo^III and Cp^xIr^III complexes equipped with the developed ligands were prepared and characterized. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Name: Chlorobis(ethylene)iridium(I) dimer).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: Chlorobis(ethylene)iridium(I) dimer

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Natural sunlight driven photocatalytic performance of Ag/ZnO nanocrystals was written by Singh, Sarika. And the article was included in Materials Today Communications in 2022.Related Products of 61-73-4 This article mentions the following:

Herein, spherical-shaped ZnO nanoparticles of an average size of about 10 nm were successfully synthesized through a soft chem. approach. We further prepared the Ag/ZnO nanocrystals by varying the loaded amounts of metallic silver nanoparticles (1, 3, and 5 wt%) without using any reducing and stabilizing agent. X-ray diffraction (XRD) and XPS anal. confirmed the transformation of Ag ions into metallic Ag and the interaction between Ag and ZnO nanoparticles. High resolution-transmission electron microscopy (HR-TEM) images revealed that Ag nanoparticles of an average size of about 4.6 nm are present on the surface of spherical ZnO nanoparticles. UV-visible absorption spectra showed that the appropriate amount of Ag loading with ZnO shifted the band gap from UV to the visible region. Photoluminescence spectrum reveals the inclusion of Ag in ZnO and minimizes the recombination of electron-hole pairs. These synthesized Ag/ZnO nanocrystals were investigated for its potential applications in photocatalytic degradation of methylene blue dye under UV and sunlight irradiation and compared their efficiency with pure ZnO. Interestingly, it is seen that ZnO nanocrystals that are UV active become visible active when loaded with 1 and 5 wt% of metallic Ag. ZnO loaded with 1 wt% of metallic Ag completely degraded the methylene blue within 3 h under natural sunlight. Under UV light, 3 wt% of Ag in ZnO exhibits higher photocatalytic performance than the others. Thus, incorporating metallic Ag in ZnO nanoparticles shows excellent photocatalyst performance and recycling capability. Furthermore, the participation of different reactive species in the photocatalysis degradation mechanism was studied using four scavengers and the results indicate that superoxide and singlet oxygen are the dominant reactive species. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Related Products of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90 was written by Buchstaller, Hans-Peter;Eggenweiler, Hans-Michael;Sirrenberg, Christian;Graedler, Ulrich;Musil, Djordje;Hoppe, Edmund;Zimmermann, Astrid;Schwartz, Harry;Maerz, Joachim;Bomke, Joerg;Wegener, Ansgar;Wolf, Michael. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Application of 6834-42-0 This article mentions the following:

Inhibitors of the Hsp90 mol. chaperone are showing considerable promise as potential mol. therapeutic agents for the treatment of cancer. Here we describe the identification of novel small mol. weight inhibitors of Hsp90 using a fragment based approach. Fragments were selected by docking, tested in a biochem. assay and the confirmed hits were crystallized Information gained from X-ray structures of these fragments and other chemotypes was used to drive the fragment evolution process. Optimization of these high μM binders resulted in 3-benzylindazole derivatives with significantly improved affinity and anti-proliferative effects in different human cancer cell lines. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics