Month: January 2023

π-Delocalization in phosphaphthalimide and its ambident reactivity (O/P) toward main-group electrophiles was written by Shen, Qi;Xu, Jiashi;Chen, Xiaodan. And the article was included in Dalton Transactions in 2022.Synthetic Route of C19H15Cl This article mentions the following:

The report on phosphaphthalimide (1), the P analog of the phthalimide anion, dates back to forty years ago. However, the presence of π-delocalization between two-coordinated P center and neighboring carbonyl groups in 1 was underestimated. Herein, Na salts of 1 were obtained through a convenient procedure on a relatively large scale with a modified procedure. Reactivity studies demonstrated that 1 is indeed a good electrophile and the essential role of π-delocalization in 1 controlling its ambident properties. NBO anal. revealed the p-π conjugation and p-σ^* hyperconjugation in 1 affecting its bond lengths in opposite ways. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s was written by Subasinghe, Nalin L.;Travins, Jeremy M.;Ali, Farah;Huang, Hui;Ballentine, Shelley K.;Marugan, Juan Jose;Khalil, Ehab;Hufnagel, Heather R.;Bone, Roger F.;DesJarlais, Renee L.;Crysler, Carl S.;Ninan, Nisha;Cummings, Maxwell D.;Molloy, Christopher J.;Tomczuk, Bruce E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Safety of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Inhibiting the classical pathway of complement activation by attenuating the proteolytic activity of the serine protease C1s is a potential strategy for the therapeutic intervention in disease states such as hereditary angioedema, ischemia-reperfusion injury, and acute transplant rejection. A series of (arylsulfonyl)-2-thiophene carboxamidine inhibitors of C1s were synthesized and evaluated for C1s inhibitory activity. A potent compound, 4-[[7-bromo-1-[(2,5-difluorophenyl)methyl]-1H-benzimidazol-5-yl]sulfonyl]-5-(methylthio)-2-thiophene-carboximidamide, had a K_i of 10 nM and >1000-fold selectivity over uPA, tPA, FX_a, thrombin, and plasmin. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Safety of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A visit to Wittig and arsa-Wittig reactions was written by Birzan, Liviu;Cristea, Mihaela;Tecuceanu, Victorita;Draghici, Constantin;Hanganu, Anamaria;Razus, Alexandru C.. And the article was included in Revista de Chimie (Bucharest, Romania) in 2020.Related Products of 620-19-9 This article mentions the following:

Some considerations regarding the mechanism of arsa-Wittig condensation have been supplemented with the synthesis of compounds substituted with the nitro to Ph and various alkyl groups to the azulene moiety. For several unknown meta-substituted 1-styrylazulenes Wittig synthesis was used. The obtained products were completely characterized. A look at the behavior of the products in NMR and UV-Vis spectrometry was taken. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Group IB organometallic chemistry. 20. The role of mixed organocopper cluster compounds RnR’mCun+m in selective carbon-carbon coupling reactions of 2- and 4-(dimethylamino)phenylcopper with copper arylacetylides was written by Van Koten, Gerard;Ten Hoedt, Richard W. M.;Noltes, Jan G.. And the article was included in Journal of Organic Chemistry in 1977.Application In Synthesis of 2-Chloro-N,N-dimethylaniline This article mentions the following:

The 1:1 interaction of ArnCun (Ar = 2-Me2NC6H4) with CuCCR (R = Ph, 4-MeC6H4, 2,4-xylyl, mesityl, 4-ClC6H4, 4-MeCC6H4, 4-O2NC6H4 in DMF at 125° affords the asym. cross-coupling products ArCCR in almost quant. yield. These reactions involve the intermediate formation of well-defined mixed organocopper cluster species Ar4Cu6(CCR)2. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Application In Synthesis of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA was written by D′Agostino, Ilaria;Ardino, Claudia;Poli, Giulio;Sannio, Filomena;Lucidi, Massimiliano;Poggialini, Federica;Visaggio, Daniela;Rango, Enrico;Filippi, Silvia;Petricci, Elena;Visca, Paolo;Botta, Lorenzo;Docquier, Jean-Denis;Dreassi, Elena. And the article was included in European Journal of Medicinal Chemistry in 2022.Synthetic Route of C19H15Cl This article mentions the following:

The ever-faster rise of antimicrobial resistance (AMR) represents a major global Public Health challenge. New chem. entities with innovative Modes of Action (MoAs) are thus desirable. We recently reported the development of a novel class of broad-spectrum bactericidal agents, the AlkylGuanidino Ureas (AGU). Due to their polycationic structure, they likely target bacterial membranes. In order to better understand their MoA, we synthesized a library of AGU derivatives by structural simplification of selected hit compounds and developed specific assays based on membrane models by means of both anal. and computational techniques. Cell-based assays provided exptl. evidence that AGUs disrupt bacterial membranes without showing hemolytic behavior. Hence, we herein report a thorough chem. and biol. characterization of a new series of AGUs obtained through mol. simplification, allowing the rational design of potent antibacterial compounds active on antibiotic-resistant strains. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Synthetic Route of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lubricoolants and an ecological safety was written by Ermolaeva, N. V.;Golubkov, Yu. V.;Zaytseva, S. Yu.;Pyo, Aung Khaing. And the article was included in Ekologiya Urbanizirovannykh Territorii in 2015.Product Details of 3386-33-2 This article mentions the following:

The mol. composition of oil-based lubricoolant SP-4 was researched with the chromatog.-mass spectrometric method. There was discovered 5 alkens, 2 sulfur-, 8 oxygen-, 6 halogen-containing and other compounds The quantity of them is 0.3…10 mkg/g and to represent danger to man and environment. There were detected the series of the specific requirements to the lubricoolants which are using in machining processes. There was suggested to introduce instead of a term “eco-friendly (safety)” lubricoolant a term “ecol.”. In turn understood by the ecol. lubricoolant you should such a lubricoolant, which makes a minimal loss for environmental and man during the preparative, operation and recycling. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Product Details of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, and testing of potent, selective hepsin inhibitors via application of an automated closed-loop optimization platform was written by Pant, Shishir M.;Mukonoweshuro, Amanda;Desai, Bimbisar;Ramjee, Manoj K.;Selway, Christopher N.;Tarver, Gary J.;Wright, Adrian G.;Birchall, Kristian;Chapman, Timothy M.;Tervonen, Topi A.;Klefstrom, Juha. And the article was included in Journal of Medicinal Chemistry in 2018.Related Products of 777-44-6 This article mentions the following:

Hepsin is a membrane-anchored serine protease whose role in hepatocyte growth factor (HGF) signaling and epithelial integrity makes it a target of therapeutic interest in carcinogenesis and metastasis. Using an integrated design, synthesis, and screening platform, we were able to rapidly develop potent and selective inhibitors of hepsin. In progressing from the initial hit (I) to compound (II), the IC₅₀ value against hepsin was improved from âˆ? μM to 22 nM, and the selectivity over urokinase-type plasminogen activator (uPA) was increased from 30-fold to >6000-fold. Subsequent in vitro ADMET profiling and cellular studies confirmed that the leading compounds are useful tools for interrogating the role of hepsin in breast tumorigenesis. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection was written by Xiong, Yusheng;Wiltsie, Judyann;Woods, Andrea;Guo, Jian;Pivnichny, James V.;Tang, Wei;Bansal, Alka;Cummings, Richard T.;Cunningham, Barry R.;Friedlander, Arthur M.;Douglas, Cameron M.;Salowe, Scott P.;Zaller, Dennis M.;Scolnick, Edward M.;Schmatz, Dennis M.;Bartizal, Kenneth;Hermes, Jeffrey D.;MacCoss, Malcolm;Chapman, Kevin T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Reference of 1138-56-3 This article mentions the following:

A potent and selective anthrax LF inhibitor (I) , was identified through SAR study of a high throughput screen lead. It has an IC₅₀ of 54 nM in the enzyme assay and an IC₅₀ of 210 nM in the macrophage cytotoxicity assay. I is also effective in vivo in several animal model studies and is orally bioavailable in dogs and rhesus monkey. In combination with ciprofloxacin I significantly increases the survival rate of mice and rabbits treated with anthrax. I is even effective prophylactically in preventing anthrax infection in spore challenges without antibiotics. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Reference of 1138-56-3).

4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 1138-56-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bridge-splitting reactions and far infrared spectra of diene derivatives of palladium(II) and platinum(II) complexes was written by Crociani, Bruno;Uguagliati, Paolo;Boschi, Tristano;Belluco, Umberto. And the article was included in Journal of the Chemical Society [Section] A: Inorganic, Physical, Theoretical in 1968.Synthetic Route of C10H10Cl2Pt This article mentions the following:

Bridge-splitting reactions of complexes of the type [M(diene.OMe)X]2 (M = Pd(II), Pt(II); diene = cycloocta-1,5-diene, dicyclopentadiene; X = Cl, Br) by neutral ligands (L) having N or P as donor atoms are reported. For the products [M(diene.OMe)LX] two structures are possible, i.e., with L cis to the olefinic double bond (A) or trans to it (B). On the basis of far-ir, spectra, structure (A) has been attributed to [Pd(diene.OMe)(py)Cl] and [Pt(diene.-OMe)LX)] (L = pyridine and p-toluidine). Structure (B) has been attributed to [Pt(diene.OMe)(PPh3)X] and to the analogous Pd(II) complexes. From [M(diene.OMe)(py)Cl] the pyridine is displaced by another neutral ligand, whereas the chloride ion is displaced only by an anionic one. The far-ir spectra (500-60 cm.-1) of the dimers [M(diene.OMe)X]2 are reported and the metal-bridging halogen stretching frequencies are assigned on the basis of a Cipoint-group symmetry. The v(M-Clbridging) falls in the range 298-216 cm.-1, v(M-Brbridging 201-148 cm.-1, and v(M-Ibridging) 165-122 cm.-1 In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Synthetic Route of C10H10Cl2Pt).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C10H10Cl2Pt

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Removal of organic pollutants from super heavy oil wastewater by lignite activated coke was written by Tong, Kun;Zhang, Yihe;Fu, Dan;Meng, Xianghai;An, Qi;Chu, Paul K.. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2014.Application In Synthesis of 1-Chlorooctadecane This article mentions the following:

Extraction of organic pollutants from super heavy oil wastewater (SHOW) by lignite activated coke (LAC) is investigated. The factors studied include the exposure time, temperature, and different pollutant concentrations in the wastewater. The equilibrium adsorption data are analyzed by the Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich (D-R) isotherms. The best match is obtained by the Freundlich isotherm and a chem. mechanism is suggested based on the D-R model. The adsorption kinetics follows the pseudo second order model and the mass transfer model suggests that external and intra-particle diffusion influences the adsorption process. Thermodn. studies show that adsorption of organic materials is spontaneous at high temperature (303 and 313 K) but not so at lower temperature (293 K) and reveals an endothermic process and increase in randomness during adsorption. The pilot dynamic adsorption test indicates that LAC can remove not only organic pollutants such as COD, NH₃-N, oils, but also inorganic pollutants such as Mg²⁺, Ca²⁺, and salts. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Application In Synthesis of 1-Chlorooctadecane).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-Chlorooctadecane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics