Month: January 2023

Metal-free oxidative coupling of alkyl chlorides with thiols: An efficient access to sulfoxides was written by Liu, Qian;Zhao, Xiaoqian;Xu, Feng;Li, Gaoqiang. And the article was included in Tetrahedron Letters in 2020.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

An efficient and step-economical access to sulfoxides from thiols and alkyl halides in the presence of I₂O₅ and DBU via direct oxidative coupling was described. It is the first case that combined Williamson sulfide synthesis and subsequent sulfide oxidation into one step manipulation for sulfoxides preparation This protocol features wide substrate scope, mild and metal-free conditons, the use of naturally abundant starting materials and avoidance of over-oxidation In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aliphatic polyamide nanofilm with ordered nanostripe, synergistic pore size and charge density for the enhancement of cation sieving was written by Yuan, Bingbing;Zhao, Siheng;Xu, Shaojie;Wang, Ning;Hu, Ping;Chen, Kuo;Jiang, Juhui;Cui, Jiabao;Zhang, Xiaozhuan;You, Meng;Niu, Q. Jason. And the article was included in Journal of Membrane Science in 2022.Name: Trimesoylchloride This article mentions the following:

Enhanced cation sieving selectivity is significant for polyamide (PA) nanofiltration membrane in terms of extracting lithium from Salt Lake brines, which enable to reduce production cost and operating energy consumption. Herein, an aliphatic PA nanofilm with ordered nanostripe was fabricated using a novel distorted and non-coplanar monomer, cyclopentane tetracarboxylic acid chloride (CPTC). Because of the fine-tuning of the dendrimer porous layer, the resultant aliphatic PA membrane revealed decreased thickness in separation layer, and an enhanced synergistic effect of size exclusion and Donnan equilibrium on mono-/divalent cation. Separation experiments indicated that a higher MgCl2 rejection (up to 98.36%) and a lower LiCl rejection (33.3%) were obtained, thus achieving a good cation selectivity (48.25 for Na⁺/Mg2⁺, 36.5 for Li⁺/Mg2⁺). This result was better compared with the full-aromatic and most of the literature reported pos. charged PA membranes. Moreover, water flux of the CPTC-tris(2-aminoethyl) amine (TAEA) membrane with nanostripe structure (N-CPTC-TAEA) increased 3.98-4.74 times (for example, 135.9 ± 4.62 for 2000 ppm LiCl) that of the CPTC-TAEA membrane. Meanwhile, the N-CPTC-TAEA also exhibited a better antifouling property than that of the full-aromatic membrane. This study demonstrates that the N-CPTC-TAEA tends to be an alternative membrane material for cation separation In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Name: Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Halogen bonding in drug-like molecules: a computational and systematic study of the substituent effect was written by Adasme-Carreno, Francisco;Munoz-Gutierrez, Camila;Alzate-Morales, Jans H.. And the article was included in RSC Advances in 2016.COA of Formula: C8H10ClN This article mentions the following:

Halogen bonding (XB) is a noncovalent interaction that has been increasingly used in mol. recognition, and more recently, in protein-ligand binding. We have studied and quantified, using d. functional theory (DFT) calculations, the substituent effect of fourteen chem. groups in the chloro-, bromo- and iodobenzene···N-methylacetamide (NMA) complexes, which serve as a model of a common arrangement of XB in biol. systems. A total of 126 halobenzene···NMA complexes have been optimized and examined regarding their relative energy, mol. electrostatic potential, topol. anal. of electron d. and charge transfer. The extent of substituent effect was found to be up to 1.5 kcal mol^-1, where electron-withdrawing groups increase the XB strength while electron-donating substituents reduce it. Excellent statistical correlations (R² > 0.9) were obtained for the comparison between XB interaction energy and the computed electronic properties (electron d., mol. electrostatic potential, and NBO charges), suggesting that the substituent effect was mainly due to the electrostatic interaction, and resonance effects were negligible. Furthermore, a pos. cooperativity effect, in the strengthening of the XB, was observed in NMA complexes with di-, tri- and tetrafluoro-iodobenzenes. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1COA of Formula: C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sulfoquinovosylglyceryl ether, a new group of ether lipids from lake ball-forming green alga Aegagropilopsis moravica (family Pithophoraceae) was written by Oku, Naoya;Hasada, Atsumi;Kimura, Kenji;Honoki, Hideharu;Katsuta, Ryo;Yajima, Arata;Nukada, Tomoo;Ishigami, Ken;Igarashi, Yasuhiro. And the article was included in Chemistry – An Asian Journal in 2021.Name: (Chloromethanetriyl)tribenzene This article mentions the following:

Ether lipids are a minor group of glycerolipids but widespread in nature, playing a vital function as membrane lipids, signalling mols., or buoyant material. We have discovered sulfoquinovosylchimyl alc. (1), a sulfonate-substituted glyceroglycolipid, from a lake ball-forming green alga Aegagropilopsis moravica (family Pithophoraceae), with the guidance of antimicrobial activity. The structure of 1, including absolute configurations of all sterogenic centers, was established by extensive NMR anal., chem. degradation studies, and finally by total synthesis. Lipid 1 is an ether variant of a lyso-form of sulfoquinovosyldiacylglycerol, a chloroplast-specific membrane lipid, and thus represents a new lipid class, sulfoquinovosylglyceryl ether. A high occurrence of mobile life form in the family Pithophoraceae and a unique behavior of chloroplasts reported in closely related Aegagropila linnaei, the famous lake-ball alga, implies a possible role of lipid 1 or its acyl derivatives in ecol. adaptation to dysphotic niches. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Name: (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nanofiltration membrane with high flux and oil rejection using graphene oxide/β-cyclodextrin for produced water reuse was written by Al-Gamal, Anwar Q.;Saleh, Tawfik A.;Alghunaimi, Fahd I.. And the article was included in Materials Today Communications in 2022.COA of Formula: C9H3Cl3O3 This article mentions the following:

A nanofiltration membrane with a high affinity to water and high rejection of salts and hydrocarbons was developed by intercalating a supramol. compound, graphene oxide with β-cyclodextrin (GO-beta-CD), into its layer of separation The GO-beta-CD membranes were synthesized by interfacial polymerization of an aqueous solution of (GO-beta-CD)/piperazine with an organic solution of 1, 3, 5-benzenetricarbonyl trichloride on porous substrates of polysulfone (PSf). Fourier transform IR spectroscopy (FTIR), field-emission scanning electron microscope (SEM), energy dispersive x-ray(EDX), and at. force microscope (AFM) analyses were applied to confirm the successful incorporation of GO-beta-CD into the rejection layer of the synthesized membrane and analyze the morphol., surface characteristics, and structure of the membrane surface. The hydrophilicity and porosity of the GO-beta-CD-embedded membranes were greatly enhanced and were confirmed by the contact angle decline and permeability enhancement. The collective results and analyses showed that the permeability, salt rejection and oil separation were significantly enhanced by the addition of GO-beta-CD. The prepared membranes were featured with hydrocarbons separation efficiency of about 100%, divalent salt rejection of about 89% and monovalent salt rejection of about 74%. The fluxes of the produced membranes were 80% greater than NF bare membranes. Addnl., the GO-beta-CD membranes were stable under a long-trail filtration of 15 h and exhibited excellent mech. and performance stability. The proposed membranes with excellent stability, high flux, salt rejection and oil rejection are highly promising for practical applications such as water desalination. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1COA of Formula: C9H3Cl3O3).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C9H3Cl3O3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Multistep Solvent-Free 3 m² Footprint Pilot Miniplant for the Synthesis of Annual Half-Ton Rufinamide Precursor was written by Escriba-Gelonch, Marc;de Leon Izeppi, Gerardo Antonio;Kirschneck, Dirk;Hessel, Volker. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.SDS of cas: 697-73-4 This article mentions the following:

The development of a pilot-scale synthesis of the rufinamide precursor in flow chem. is reported. Complex steps such as Taylor-flow, segmented flow, and high-temperature processing at high pressure (high-p,T) are successfully combined, overcoming the mixing and heat transfer issues of the scale-up. The cascaded multistep process operates essentially solvent-free in just 3 m² giving a productivity of 47 g/h (>400 kg/yr), which increases by a factor of 7 the lab-scale productivity previously reported as a scale-up proof-of-concept. This publication also includes an economic study of the feasible implementation of this technol. for a possible manufacturer, as well as an outline on business development strategies of how to implement such a disruptive technol. The development of a pilot-scale synthesis of the rufinamide precursor in flow chem. is reported. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of oxidation of benzyl alcohol and substituted benzyl alcohols by N-chlorosaccharin was written by Vijaya Mohan, K.;Rao, P. Raghunatha;Sundaram, E. V.. And the article was included in Proceedings of the National Academy of Sciences, India, Section A: Physical Sciences in 1988.Computed Properties of C7H4ClNO3S This article mentions the following:

The acid catalyzed oxidation of benzyl alcs. by N-chlorosaccharin was studied in aqueous AcOH medium in the presence of saccharin. The reaction is first-order with respect to [substrate] and [oxidant]. A plot of log k_obs vs. ρ is linear with σ = -3.07. The rate is not affected by added Cl^–. Bunnett’s plot shows that water mols. act as proton transfer agents in the rate determining step. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Computed Properties of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Trichloroisocyanuric acid oxidation of 2-chloro aldehyde acetals to 2-chloro acid esters was written by Boni, Monica;Ghelfi, Franco;Pagnoni, Ugo Maria;Pinetti, Adriano. And the article was included in Bulletin of the Chemical Society of Japan in 1994.Application In Synthesis of Methyl 2-chloro-2-phenylacetate This article mentions the following:

2-Chloro acid Me esters were prepared in good yields by treating 2-chloro aldehyde di-Me acetals with trichloroisocyanuric acid in DMF. Aldehyde di-Me acetals with the 2-halogen on a tertiary carbon atom were poorly reactive and could be oxidized efficiently only after their transformation into 1,3-dioxolanes. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Application In Synthesis of Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of new 1,3,4-oxadiazoles as antibacterial and antifungal agents was written by Revanasiddappa, B. C.;Varghese, Saira Susan;Kalsi, Jasmine;Jisha, M. S.;Jose, Neethu. And the article was included in Indian Journal of Heterocyclic Chemistry in 2014.HPLC of Formula: 34662-36-7 This article mentions the following:

A new series of 1,3,4 oxadiazoles I (R = H, 4-Cl, 4-OH, etc.) were prepared by reacting 2-hydroxybenzohydrazide with substituted aromatic acids in presence of phosphorous oxychloride. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antifungal activities. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7HPLC of Formula: 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Syntheses of new pyridonecarboxylic acid derivatives containing 3-, 5- or 6-quinolyl substituents at N-1 and their anti-HIV-RT activities was written by Oh, Yoon-Seok;Lee, Chi-Woo;Chung, Yong-Ho;Yoon, Sung-June;Cho, Sung-Hye. And the article was included in Journal of Heterocyclic Chemistry in 1998.Application of 96568-04-6 This article mentions the following:

A series of new pyridonecarboxylic acid derivatives containing 3-, 5-, or 6-quinolyl substituents at N-1 were synthesized and their in vitro anti-HIV-RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Application of 96568-04-6).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 96568-04-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics