Month: January 2023

Asymmetric Synthesis of Spirooxazolidinone Oxindoles by the Thiourea-Catalyzed Aldol Reaction of 2-Isocyanatomalonate Diesters was written by Chen, Xiao-Pan;Liu, Jin-Xin;Li, Hong-Yan;Xiao, You-Cai;Chen, Fen-Er. And the article was included in Advanced Synthesis & Catalysis in 2022.Product Details of 76-83-5 This article mentions the following:

A tertiary amino-thiourea catalyzed asym. aldol reaction between 2-isocyanatomalonate esters and isatins was achieved. Optical active spirooxazolidinone oxindole derivatives I [R = Me, Bn, trityl, etc.; R¹ = H, 4-Me, 5-i-Pr, etc.; R² = Me, Et, Bn, etc.; X = C, N] were obtained with excellent yields (80%-96%) and enantioselectivities (67%-99% ee) under mild conditions, providing an updated example to apply isatins as the electrophile in the asym. aldol reaction with 2-isocyanatomalonate esters. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Product Details of 76-83-5).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 76-83-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of β-Keto Sulfones by Oxy-Sulfonylation of Alkynes in HFIP was written by Chen, Xingyu;Lu, Sixian;Zheng, Yuyan;Wang, Jigang;Yang, Lan;Sun, Peng. And the article was included in Advanced Synthesis & Catalysis in 2022.Recommanded Product: 777-44-6 This article mentions the following:

Herein, authors have established a method for the construction of β-keto sulfones through aerobic oxy-sulfonylation of alkynes with sulfinates. The reaction performed employing air as the oxidant and oxygen source. Moreover, this protocol exhibits low consume of sulfinates, short reaction period, and minimal waste. Mechanism study and d. functional theory (DFT) calculation showed that the solvent played a significant role in the transformation. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Recommanded Product: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors was written by Abdelazem, Ahmed Z.;Al-Sanea, Mohammad M.;Park, Byung Sun;Park, Hye Mi;Yoo, Kyung Ho;Sim, Taebo;Park, Jong Bae;Lee, Seung-Hoon;Lee, So Ha. And the article was included in European Journal of Medicinal Chemistry in 2015.SDS of cas: 85953-29-3 This article mentions the following:

With the aim of discovering potent and selective kinase inhibitors targeting ROS1 kinase, we designed, synthesized and screened a series of new pyrazol-4-ylpyrimidine derivatives based on our previously discovered lead compound KIST301072. Compounds I (R’ = H, Me) showed good to excellent activities against ROS1 kinase, and seven out of tested compounds were more potent than KIST301072. Compound I (R = CH₂CH₂CH₂CH₂OH, R’ = H) was the most potent with IC₅₀ of 24 nM. Moreover, compound I (R = CH₂CH₂CH₂CH₂OH, R’ = H) showed ROS1 inhibitory selectivity of about 170-fold, relative to that of ALK sharing about 49% amino acid sequence homol. with ROS1 kinase in the kinase domain. In silico modeling of 7c at ROS1 active site revealed some essential features for ROS1 inhibitory activity. Based on this study and the previous studies, we could build a hypothetical model predicting the required essential features for ROS1 inhibitory activity. The model validity was tested through a second set of compounds In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3SDS of cas: 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 1,2,3,4-tetrafluorobenzene by potassium fluoride fluorination was written by Finger, G. C.;Shiley, R. H.;Dickerson, D. R.. And the article was included in Journal of Fluorine Chemistry in 1974.HPLC of Formula: 2613-34-5 This article mentions the following:

1,2,3,4-C6H2F4 (I) was prepared in ∼26% yield by reaction of 2,3,6-F3C6H2Cl with KF-CsF in Me2SO2 at ∼265° for 1.5-2 hr. With KF alone the yield of I was 16.4%. The yield of I by similar reaction with 2,3,4-F3C6H2Cl did not exceed 2.5% even when CsF was used alone. The fluorination of 2,3,1,4-Cl2F2C6H2 via this halogen exchange reaction gave 22.6% I, but under similar conditions 3,4,1,2- and 2,4,1,3-Cl2F2C6H2 gave I in 1.8 and 1.3% yield, resp. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,4-difluoroaniline (cas: 2613-34-5HPLC of Formula: 2613-34-5).

3-Chloro-2,4-difluoroaniline (cas: 2613-34-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 2613-34-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies was written by Jung, Sascha;Fuchs, Natalie;Johe, Patrick;Wagner, Annika;Diehl, Erika;Yuliani, Tri;Zimmer, Collin;Barthels, Fabian;Zimmermann, Robert A.;Klein, Philipp;Waigel, Waldemar;Meyr, Jessica;Opatz, Till;Tenzer, Stefan;Distler, Ute;Raeder, Hans-Joachim;Kersten, Christian;Engels, Bernd;Hellmich, Ute A.;Klein, Jochen;Schirmeister, Tanja. And the article was included in Journal of Medicinal Chemistry in 2021.Category: chlorides-buliding-blocks This article mentions the following:

Rhodesain is a major cysteine protease of Trypanosoma brucei rhodesiense, a pathogen causing Human African Trypanosomiasis, and a validated drug target. Recently, we reported the development of α-halovinylsulfones as a new class of covalent reversible cysteine protease inhibitors. Here, α-fluorovinylsulfones/-sulfonates were optimized for rhodesain based on mol. modeling approaches. I (X = F), the most potent and selective inhibitor in the series, shows a single-digit nanomolar affinity and high selectivity toward mammalian cathepsins B and L. Enzymic dilution assays and MS experiments indicate that I (X = F) is a slow-tight binder (K_i = 3 nM). Furthermore, the nonfluorinated I (X = H) shows favorable metabolism and biodistribution by accumulation in mice brain tissue after i.p. and oral administration. The highest antitrypanosomal activity was observed for inhibitors with an N-terminal 2,3-dihydrobenzo[b][1,4]dioxine group and a 4-Me-Phe residue in P2 with nanomolar EC₅₀ values (0.14/0.80μM). The different mechanisms of reversible and irreversible inhibitors were explained using QM/MM calculations and MD simulations. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Category: chlorides-buliding-blocks).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pd-Catalyzed decarboxylative cross coupling of potassium polyfluorobenzoates with aryl bromides, chlorides, and triflates was written by Shang, Rui;Xu, Qing;Jiang, Yuan-Ye;Wang, Yan;Liu, Lei. And the article was included in Organic Letters in 2010.Computed Properties of C7H3ClF2O2 This article mentions the following:

Pd-catalyzed decarboxylative cross coupling of potassium polyfluorobenzoates with aryl bromides, chlorides, and triflates is achieved by using diglyme as the solvent. The reaction is useful for synthesis of polyfluorobiaryls from readily accessible and nonvolatile polyfluorobenzoate salts. Unlike the Cu-catalyzed decarboxylation cross coupling where oxidative addition is the rate-limiting step, in the Pd-catalyzed version decarboxylation is the rate-limiting step. In the experiment, the researchers used many compounds, for example, 3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7Computed Properties of C7H3ClF2O2).

3-Chloro-2,6-difluorobenzoic acid (cas: 225104-76-7) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H3ClF2O2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rapid Upcycling of End-of-Life Microfiltration Membrane Mediated by the Healing of Metal-Organic Complex was written by Wang, Xueye;Han, Hongyi;Zhou, Huimin;Wang, Tianlin;Dai, Ruobin;Wang, Zhiwei. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Recommanded Product: Trimesoylchloride This article mentions the following:

Membrane separation is widely adopted in many industries, and the membranes reach their end of life (EOL) after long-term use. However, the conventional approach of replacing EOL membranes has a high carbon footprint, hindering the development of a green, low-carbon, and carbon-neutral process. In this study, we developed a cleaning-tannic acid-iron (TA-Fe)-healing-interfacial polymerization strategy with a reaction time of less than 20 min for the upcycling of an EOL microfiltration (MF) membrane. The cleaning step could remove most of the foulants from the EOL membrane. The TA-Fe healing step decreased the surface pore size and increased the hydrophilicity of the cleaned membrane, offering a more favorable platform for the storage of amine monomers required for interfacial polymerization The upcycled NF-Healed membrane possessed a Na₂SO₄ rejection of 96.9 ± 0.7% and high pure water permeance of 23.7 ± 1.4 L m^-2 h^-1 bar^-1. An economic anal. indicated that the chem. cost for upcycling was ~$4.9/m² membrane, which was lower than the estimated cost to replace the EOL MF membrane. This study provides a rapid and cost-effective method for the upcycling of the EOL MF membrane, which is a promising strategy to close the sustainable loop in the membrane materials. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Recommanded Product: Trimesoylchloride).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: Trimesoylchloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells was written by Landi, Martina;Catelani, Giorgio;D’Andrea, Felicia;Ghidini, Eleonora;Amari, Gabriele;Paola, Puccini;Bianchi, Nicoletta;Gambari, Roberto. And the article was included in European Journal of Medicinal Chemistry in 2009.Reference of 6834-42-0 This article mentions the following:

A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- and D-allofuranose as well as their 5,6-O-deprotected analogs and Me 3,4-O-isopropylidene-α- and β-D-galactopyranosides have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythro-leukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Localization of α 2u-globulin in the acinar cells of preputial gland, and confirmation of its binding with farnesol, a putative pheromone, in field rat (Millardia meltada) was written by Rajamanickam, Ramachandran;Shanmugam, Achiraman;Thangavel, Rajagopal;Devaraj, Sankarganesh;Soundararajan, Kamalakkannan;Ponnirul, Ponmanickam;Ramalingam, Rajkumar;Ganesan, Ramya Vaideki;Parasuraman, Padmanabhan;Govindaraju, Archunan. And the article was included in PLoS One in 2018.Related Products of 3386-33-2 This article mentions the following:

Pheromones, low mol. weight chem. entities that bind to pheromone carrier proteins, are chem. signals that play an important role in the communication system in animals. This has been rather fairly well-studied in the rodents. The preputial gland, a rich source of pheromones in many rodents, contains a low mol. mass protein (18-20 kDa) that acts as one such pheromone carrier. However, the presence of this protein in the notorious rodent pest Millardia meltada has not yet been proven. Therefore, we aimed at identifying this protein, and the pheromones that are bound to it, in this rodent so as to utilize the information in the control of this pest. Twenty volatile compounds were identified in the preputial gland using GC-MS. Total protein of the gland was fractioned by both one and twodimensional electrophoresis when we identified a low mol. mass protein (19 kDa, pI- 4.7). Adopting MALDI-TOF MS and LC-MS analyses, the protein was confirmed as α 2u-globulin. To identify the volatiles bound to this protein, we used column chromatog. and GC-MS. We found that farnesol and 6-methyl-1-heptanol are the volatiles that would bind to the protein, which we propose to be putative pheromones. Immunohistochem. anal. confirmed localization of α 2u-globulin in the acinar cells of the preputial gland. Thus, we show that α 2u-globulin, a pheromone-carrier protein, is present in the preputial gland acinar cells of M. meltada and suggest farnesol and 6-methyl-1-heptanol to be the volatiles which would bind to it. The α 2u-globulin together with farnesol and 6-methyl-1-heptanol contribute to pheromonal communication of M. meltada. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Related Products of 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Methylation of aromatic amines by the Wallach method was written by Borkowski, Walter L.;Wagner, E. C.. And the article was included in Journal of Organic Chemistry in 1952.Quality Control of 2-Chloro-N,N-dimethylaniline This article mentions the following:

The methylation of PhNH₂, o- (I) and p-MeC₆H₄NH₂ (II), 5,2-BrMeC₆H₃NH₂ (III), o-ClC₆H₄NH₂ (IV), and 2,6- (V) and 2,4-xylidine (VI) with (HCHO)_n and HCO₂H, HCl, HBr, or AcOH, or without acid shows that, without acid, only negligible condensation takes place. Heating PhNMe₂, (HCHO)_n, and 98% HCO₂H (1:1:1) 1 h. gives 92% (p-Me₂NC₆H₄)₂CH₂, m. 85-6°; p-MeC₆H₄NMe₂, (HCHO)_n, and HCO₂H (1:1:1), heated 3.5 h., give 98% [5,2-Me(Me₂N)C₆H₃]₂CH₂. Heating V, (HCHO)_n, and HCO₂H (1:3:3) 0.5 h. gives 33% 2,6-Me₂C₆H₃NMe₂, b. 194-9°, and 63% diphenylmethane base, b_0.8 170.5°, m. 49.5-50.5°, resolidifying and m. again 60-60.5°; 2,6-Br₂C₆H₃NH₂ (VII), (HCHO)₃, and HCO₂H (1:3:8), heated 3 h., give 83% [3,5,4-Br₂(H₂N)C₆H₂]₂CH₂, m. 159-60°; m-O₂NC₆H₄NH₂ (VIII), (HCHO)_n, and HCO₂H (1:2.6:4), heated 10.5hrs., give [4,2-Me₂N(O₂N)C₆H₃]₂CH₂, m. 191-2°. II, (HCHO)_n, and HCO₂H (1:3:3), heated 0.5 h., give a trace of p-MeC₆H₄NMe₂ and 10% 3-p-tolyl-6-methyl-3,4-dihydroquinazoline, m. 156.5-7°. VI (0.2 mol.) added to (HCHO)_n and HCO₂H (1:3:3)reacts vigorously; when the mixture is heated 0.5 h. 33% 2,4-Me₂C₆H₃NMe₂ and an unidentified compound, b_0.8 186-7°, m. 165-6°, are formed. Similarly, 2,4-Cl₂C₆H₃NH₂ (IX), (HCHO)_n, and HCO₂H (1:3:3) give 84% 2,4-Cl₂C₆H₃NMe₂, m. 169.5-70.5°, which is changed when refluxed with Ac₂O alone or with C₅H₅N. The rate of methylation is measured by determining the CO₂ formed. After an extensive study of the effect of the amount of HCHO, of H₂O, of variation in the amounts of HCO₂H, of strong acids, of the order of mixing the reagents, and of agitation, the results of which are given in 5 tables, a modified procedure for the Wallach methylation of aromatic amines is given: 1 mol. amine is added gradually to a gently warmed and stirred mixture of 2.5 mols. (HCHO)_n and 3 mols. HCO₂H, the mixture heated 5 min. on a steam bath, poured into ice-cold NaOH (1.3 equivalents to 1 of the HCO₂H) and Na₂SO₃ (1.2 equivalents to 1 of the HCHO), the solution steam-distilled, and the distillate extracted with ether. In this way the following amines give the corresponding N,N-di-Me derivatives (% yield): 1 40, II 50, IV 23, p-isomer 65, VI 65, V 97, p-O₂NC₆H₄NH₂ 50, p-MeOC₆H₄NH₂ 50, mesidine 98, IX 92, VII 92, 2,4-MeBrC₆H₃NH₂ 98, 2,4,6-Br₃C₆H₂NH₂ 98, o-MeC₆H₄NHMe 55, p-isomer 95, 2,4-Me₂C₆H₃NHMe 98, 2,6-isomer 98. PhNH₂, m-MeC₆H₄NH₂, 1- and 2-C₁₀H₇NH₂, p-H₂N’C₆H₄SO₃H, VIII, PhNHMe, and m-MeC₆H₄NHMe are not methylated by this procedure. The primary and secondary amines successfully methylated all have 1 or more of the o- and p-H atoms replaced. With all reactive positions unsubstituted, the nuclear condensations predominate; with 1 or 2 reactive positions blocked, methylation reaches 90%; with all reactive positions blocked, methylation is almost 100%. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Quality Control of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Quality Control of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics