Month: January 2023

Effect of endocrine disrupting chemicals on vitronectin-receptor (integrin alphaVbeta3)-mediated cell adhesion of human umbilical vein endothelial cells was written by Kenda, Masa;Pecar Fonovic, Ursa;Kos, Janko;Sollner Dolenc, Marija. And the article was included in Toxicology In Vitro in 2022.Synthetic Route of C13H9Cl3N2O This article mentions the following:

Endocrine disrupting chems. (EDCs) are associated with cancer development and progression due to their promotion of increased cell invasiveness and metastasis formation. However, the effects of EDCs on cell adhesion mediated through integrins have not been well studied to date. Their actions are implicated by binding sites for hormones on the vitronectin receptor (VTNR; or integrin αvβ3), which is involved in tumor angiogenesis and metastasis. VTNR-expressing human umbilical vein endothelial cells (HUVECs) were used to determine the effects of EDCs and endogenous hormones on cell adhesion to vitronectin-coated surfaces, and on VTNR activation. Cell adhesion was significantly increased for bisphenol A, triclocarban, and triclosan (10, 100 nM; p < 0.05), with similar trends for bisphenols AF and S (10, 100 nM; p > 0.05). No changes in cell adhesion were seen for 5α-dihydrotestosterone, 17β-estradiol, triiodothyronine, imatinib and paroxetine. These data indicate that EDC-mediated increases in HUVEC adhesion to vitronectin are not mediated through androgenic, estrogenic, or thyroid activities, nor through activation of VTNR. Although these effects of EDCs on HUVEC adhesion require further investigation of the underlying mechanism(s) of action to define their biol. relevance, the low-dose effects and nonmonotonic responses revealed here define the need for further investigation of these EDCs. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Synthetic Route of C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo was written by Fu, Dong-Jun;Song, Jian;Zhu, Ting;Pang, Xiao-Jing;Wang, Sheng-Hui;Zhang, Yan-Bing;Wu, Bo-Wen;Wang, Jun-Wei;Zi, Xiaolin;Zhang, Sai-Yang;Liu, Hong-Min. And the article was included in European Journal of Medicinal Chemistry in 2020.Computed Properties of C8H9Cl This article mentions the following:

NEDDylation pathway regulates multiple physiol. process, unlike inhibitors, NEDDylation activators are rarely studied. Novel amide derivatives were synthesized and evaluated for antiproliferative activity against MGC803, MCF-7 and PC-3 cells. Among them, VII-31 displayed the most potent activity with an IC₅₀ value of 94 nmol/L against MGC803 cells. Cellular mechanisms elucidated that VII-31 inhibited the cell viability, arrested cell cycle at G2/M phase and induced apoptosis via intrinsic and extrinsic pathways against MGC803 cells. In addition, VII-31 activated NAE1-Ubc12-Cullin1 NEDDylation via interacting with NAE1 directly. Furthermore, the activation of NEDDylation resulted in the degradation of inhibitor of apoptosis proteins (IAPs). Importantly, VII-31 inhibited tumor growth in xenograft models in vivo without the apparent toxicity. In summary, it is the first time to reveal that VII-31 deserves consideration for cancer therapy as a NEDDylation activator. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Computed Properties of C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: Sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors was written by Majmudar, Jaimeen D.;Hahne, Kalub;Hrycyna, Christine A.;Gibbs, Richard A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Formula: C8H9ClO4S This article mentions the following:

Human isoprenylcysteine carboxyl methyltransferase (hIcmt) is a promising anticancer target as it is important for the post-translational modification of oncogenic Ras proteins. We herein report the synthesis and biochem. activity of 41 farnesyl-cysteine based analogs vs. hIcmt. We have demonstrated that the amide linkage of a hIcmt substrate can be replaced by a sulfonamide bond to achieve hIcmt inhibition. The most potent sulfonamide-modified farnesyl cysteine analog was 6ag with an IC₅₀ of 8.8 ± 0.5 μM for hIcmt. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Formula: C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

17β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffold was written by Wetzel, Marie;Marchais-Oberwinkler, Sandrine;Hartmann, Rolf W.. And the article was included in Bioorganic & Medicinal Chemistry in 2011.COA of Formula: C9H9ClO2 This article mentions the following:

17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) catalyzes the conversion of active 17β-hydroxysteroids into the less active 17-ketosteroids thereby controlling the availability of biol. active estrogens (E2) and androgens (T) in the tissues. The skeletal disease osteoporosis occurs mainly in post-menopausal women and in elderly men when the levels of estrogens and androgens, resp., decrease. Since 17β-HSD2 is present in osteoblasts, inhibition of this enzyme may provide a new and promising approach to prevent the onset of osteoporosis, keeping a certain level in estrogens and androgens in bone cells of ageing people. Hydroxynaphthyl, hydroxyphenyl and hydroxymethylphenyl-substituted moieties were synthesized as mimetics of the steroidal substrate. Compound 8 has been identified as promising scaffold for 17β-HSD2 inhibitors displaying high activity and good selectivity toward 17β-HSD1, ERα and ERβ. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C9H9ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

High adsorption and photocatalytic degradation abilities of amorphous Ta₂O₅ nanospheres under simulated solar light irradiation was written by Fu, Haitao;Chen, Fu;Wang, Yan;Yang, Xiaohong;Xiong, Shixian;An, Xizhong. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Related Products of 61-73-4 This article mentions the following:

In this study, the crystallized and amorphous Ta₂O₅ nanospheres were successfully synthesized by a simple alc.-thermal reaction. The particle sizes of amorphous Ta₂O₅ nanospheres were controlled by adjusting the PVP amount in the synthetic system. The removal abilities of the Ta₂O₅ towards organic dyes were assessed by measuring the adsorption and the photocatalytic degradation performance towards methylene blue (MB) under dark condition and simulated solar light irradiation, resp. The results indicate that the amorphous Ta₂O₅ prepared with 1:5 PVP (a-Ta₂O₅ 5PVP) exhibited extremely high adsorption abilities and photocatalytic degradation performances, compared to the crystallized and other amorphous Ta₂O₅ nanospheres. The excellent MB removal ability of a-Ta₂O₅ 5PVP can be attributed to high sp. surface area, extra O vacancies, enhanced visible light absorption, more photo-generated electrons and low charge transfer resistance. This study may shed light on a simple but low-cost preparation strategy for amorphous Ta₂O₅ nanospheres suitable for the future practical application on wastewater treatment and provide deep insights on the underlying reasons for the high removal performance to organic dyes. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Related Products of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metal- and Oxidant-Free Green Three-Component Desulfurization and Deamination Condensation Approach to Fully Substituted 1H-1,2,4-Triazol-3-amines and Their Photophysical Properties was written by Guo, Wei;Liu, Gongping;Deng, Ling;Mei, Weijie;Zou, Xiaoying;Zhong, Yumei;Zhuo, Xiaoya;Fan, Xiaolin;Zheng, Lvyin. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 18637-02-0 This article mentions the following:

A metal-/oxidant-free three-component desulfurization and deamination condensation of amidines, isothiocyanates and hydrazines for the synthesis of structurally diverse full substituted 1H-1,2,4-triazol-3-amines I [R = Me, c-hexyl, Ph, etc.; R¹ = Me, Ph, 3-pyridyl, etc.; R² = c-hexyl, Ph, 2-pyridyl, etc.] was described. The reaction proceeded without the requirement of any external catalysts, metals, ligands and oxidants. This [2 + 1 + 2] cyclization strategy involved C-N/C-S bond cleavage and new C-N bonds formation in one pot. This transformation provided a series of full substituted 1H-1,2,4-triazol-3-amines with advantages of broad substrates scope, mild reaction conditions, environmental friendliness and easily gram-scale applications. The fluorescence and aggregation-induced emission (AIE) properties of selected products were further tested. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0SDS of cas: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biomimetic Total Syntheses of (+)-Chloropupukeananin, (-)-Chloropupukeanolide D, and Chloropestolides was written by Suzuki, Takahiro;Watanabe, Soichiro;Ikeda, Wataru;Kobayashi, Susumu;Tanino, Keiji. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C9H9ClO3 This article mentions the following:

Chloropupukeananin, chloropupukeanolides, and chloropestolides are a family of structurally complex bioactive natural products that possess highly functionalized tricyclo[4.3.1.03,7]decane or bicyclo[2.2.2]octane skeletons. Biosynthesis of the chloropupukeananin family is triggered by the intermol. heterodimeric Diels-Alder reaction between maldoxin and iso-A82775C; however, the enzymes involved have not yet been identified. Herein report the one-pot biomimetic synthesis of chloropupukeananin and chloropupukeanolide D. Moreover, the effect of the solvent on the intermol. Diels-Alder reaction of siccayne and maldoxin suggested that the biosynthesis of the chloropupukeananin family involves a Diels-Alderase-catalyzed heterodimeric Diels-Alder reaction. In the experiment, the researchers used many compounds, for example, 4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5COA of Formula: C9H9ClO3).

4-Chloro-2,5-dimethoxybenzaldehyde (cas: 90064-48-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Regiocontrolled palladium-catalyzed direct C2-arylations of Methoxalen using benzenesulfonyl chlorides and C2,C3-diarylations using aryl bromides as the aryl sources was written by Li, Haoran;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in Tetrahedron Letters in 2020.Synthetic Route of C7H4ClF3O2S This article mentions the following:

Conditions for the regioselective palladium-catalyzed direct C2-arylation and C2,C3-diarylation of methoxalen were described. The use of benzenesulfonyl chlorides as the coupling partner allowed control of the regioselectivity of the arylation in favor of the C2 carbon of methoxalen. This method tolerated a variety of substituents on the benzenesulfonyl chloride derivatives Notably, 2-, 3- and 4-bromobenzenesulfonyl chlorides and 4-iodobenzenesulfonyl chloride were coupled with methoxalen without cleavage of the C-Br or C-I bonds. Conversely, the use of an excess amount of aryl bromides as the aryl source provided access to C2,C3-diarlyated methoxalenes. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Synthetic Route of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and antitumor study of novel 1,4-bispiperazinecarbodithioic acid [1 -substituted-(1,2,3-triazole)-4]-methyl esters was written by Wang, Mengmeng;Duan, Yingchao;Ye, Xianwei;Ren, Jingli;Yu, Bin;Zhang, En;Liu, Hongmin. And the article was included in Youji Huaxue in 2013.Computed Properties of C7H5ClF2 This article mentions the following:

In order to find novel lead compounds with promising antitumor activity, a series of novel 1,4-bispiperazinecarbodithioic acid [1 -substituted-(1,2,3-triazole)-4]-Me esters were designed and synthesized. Piperazine reacting with CS₂ and propargyl bromide in the presence of Na₃PO₄ · 12H₂O in one pot gave compound 1, which was further reacted with appropriately substituted azide derivatives by click reaction to afford desired target compounds The structures were characterized by ¹H NMR, ¹³C NMR and HRMS. The compounds were evaluated for antitumor activity against four selected human tumor cell lines of EC-9706, MGC-803, SMMC-7721 and MCF-7. Several compounds exhibited moderate to potent activity. Particularly, compound I was more potent than 5-fluorouracil against MGC-803 and SMMC-7721 with IC50 values of 11.15 and 14.75 μmol/L. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Computed Properties of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-Catalyzed Alkylarylation of Unactivated Alkenes: Synthesis of 3-Alkyl Indolines from N-Allyl Anilines and Alkanes was written by Liang, Deqiang;Huo, Bojie;Dong, Yongrui;Wang, Yan;Dong, Ying;Wang, Baoling;Ma, Yinhai. And the article was included in Chemistry – An Asian Journal in 2019.Reference of 18437-66-6 This article mentions the following:

A rare example of C(sp³)-H functionalization of simple alkanes with unactivated alkenes was presented. In the presence of a copper salt and di-tert-Bu peroxide (DTBP), N-allyl anilines underwent exo-selective alkylation/cyclization cascade with unactivated alkenic bonds as radical acceptors and simple alkanes as radical precursors, providing a direct access to 3-alkyl indolines I [R = H, 5-Cl, 5-Ph, etc.; R¹ = C(Me)₂CH₂CH₃, cyclopentyl, cyclohexyl, etc.; R² = C(O)Me, Boc, SO₂Et, etc.]. The present protocol featured simple operation, broad substrate scope and great exo selectivity. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Reference of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics