Month: January 2023

Synthesis and Characterization of Carbazolide-Based Iridium PNP Pincer Complexes. Mechanistic and Computational Investigation of Alkene Hydrogenation: Evidence for an Ir(III)/Ir(V)/Ir(III) Catalytic Cycle was written by Cheng, Chen;Kim, Bong Gon;Guironnet, Damien;Brookhart, Maurice;Guan, Changjian;Wang, David Y.;Krogh-Jespersen, Karsten;Goldman, Alan S.. And the article was included in Journal of the American Chemical Society in 2014.Synthetic Route of C8H16Cl2Ir2 This article mentions the following:

New carbazolide-based Ir pincer complexes (^carbPNP)Ir(C₂H₄) (3a, ^carbPNPH = 1,8-bis[(diisopropylphosphino)methyl]-3,6-dimethyl-9H-carbazole) and (^carbPNP)Ir(H)₂ (3b) were prepared and characterized. The dihydride, 3b, reacts with ethylene to yield the cis-dihydride ethylene complex cis-(^carbPNP)Ir(C₂H₄)(H)₂. Under ethylene this complex reacts slowly at 70° to yield ethane and the ethylene complex, 3a. Kinetic anal. establishes that the reaction rate is dependent on ethylene concentration and labeling studies show reversible migratory insertion to form an Et hydride complex prior to formation of 3a. Exposure of cis-(^carbPNP)Ir(C₂H₄)(H)₂ to H results in very rapid formation of ethane and dihydride, 3b. DFT anal. suggests that ethane elimination from the Et hydride complex is assisted by ethylene through formation of (^carbPNP)Ir(H)(Et)(C₂H₄) and by H₂ through formation of (^carbPNP)Ir(H)(Et)(H₂). Elimination of ethane from Ir(III) complex (^carbPNP)Ir(H)(Et)(H₂) is calculated to proceed through an Ir(V) complex (^carbPNP)Ir(H)₃(Et) which reductively eliminates ethane with a very low barrier to return to the Ir(III) dihydride, 3b. Under catalytic hydrogenation conditions (C₂H₄/H₂), cis-(^carbPNP)Ir(C₂H₄)(H)₂ is the catalyst resting state, and the catalysis proceeds via an Ir(III)/Ir(V)/Ir(III) cycle. This is in sharp contrast to isoelectronic (PCP)Ir systems in which hydrogenation proceeds through an Ir(III)/Ir(I)/Ir(III) cycle. The basis for this remarkable difference is discussed. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Synthetic Route of C8H16Cl2Ir2).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C8H16Cl2Ir2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of small molecule agonists of EphA2 receptor was written by Petty, Aaron;Idippily, Nethrie;Bobba, Viharika;Geldenhuys, Werner J.;Zhong, Bo;Su, Bin;Wang, Bingcheng. And the article was included in European Journal of Medicinal Chemistry in 2018.Recommanded Product: 6834-42-0 This article mentions the following:

Ligand-independent activation of EphA2 receptor kinase promotes cancer metastasis and invasion. Activating EphA2 receptor tyrosine kinase with small mol. agonist is a novel strategy to treat EphA2 overexpressing cancer. In this study, we performed a lead optimization of a small mol. Doxazosin that was identified as an EphA2 receptor agonist. 33 new analogs were developed and evaluated; a structure-activity relationship was summarized based on the EphA2 activation of these derivatives Two new derivative compounds 24 and 27 showed much improved activity compared to Doxazosin. Compound 24 possesses a bulky amide moiety, and compound 27 has a dimeric structure that is very different to the parental compound Compound 27 with a twelve-carbon linker of the dimer activated the kinase and induced receptor internalization and cell death with the best potency. Another dimer with a six-carbon linker has significantly reduced potency compared to the dimer with a longer linker, suggesting that the length of the linker is critical for the activity of the dimeric agonist. To explore the receptor binding characteristics of the new mols., we applied a docking study to examine how the small mol. binds to the EphA2 receptor. The results reveal that compounds 24 and 27 form more hydrogen bonds to EphA2 than Doxazosin, suggesting that they may have higher binding affinity to the receptor. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Recommanded Product: 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enzymatic Desymmetrization of Prochiral 2-Substituted-1,3-Diamines: Preparation of Valuable Nitrogenated Compounds was written by Rios-Lombardia, Nicolas;Busto, Eduardo;Garcia-Urdiales, Eduardo;Gotor-Fernandez, Vicente;Gotor, Vicente. And the article was included in Journal of Organic Chemistry in 2009.Reference of 6834-42-0 This article mentions the following:

A wide range of prochiral 1,3-diamines were first efficiently synthesized and subsequently desymmetrized by using lipase from Pseudomonas cepacia as catalyst and diallyl carbonate as alkoxycarbonylating agent. In all cases, the amino carbamates of R-configuration were recovered. Final selective cleavage of the N-allyloxycarbonyl moiety was carried out under mild reaction conditions, which demonstrates the high versatility and potential of this chemoenzymic route as a source of intermediates in the synthesis of related optically active nitrogenated derivatives In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Reference of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Examining the structure-activity relationship of benzopyran-based inhibitors of the hypoxia inducible factor-1 pathway was written by Ferguson, Jalisa;De Los Santos, Zeus;Devi, Narra;Van Meir, Erwin;Zingales, Sarah;Wang, Binghe. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

Many forms of solid tumor have a characteristic feature known as hypoxia, which describes a low or nonexistent presence of oxygen in the cellular microenvironment. This decrease in oxygen causes activation of the hypoxia inducible factor (HIF) pathway, which activates the transcription of many genes that cause cell proliferation, metastasis, increased glycolysis and angiogenesis. Increased HIF expression has been linked with poor patient prognosis, increased malignancy, and therapeutic resistance. Previous work in the lab has identified I and II as inhibitors of the HIF pathway, specifically as disrupters of the p300-HIF-1α complex formation. A library of sulfonamide analogs has been designed and synthesized with the intent of examining the SAR of this series of compounds and improving potency and physicochem. properties as compared with lead compounds I and II. At the end, the authors have achieved a thorough understanding of the structural features critical for future optimization work. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2 was written by Pires, Layla;Wilson, Brian C.;Bremner, Rod;Lang, Amanda;Larouche, Jeremie;McDonald, Ryan;Pearson, Joel D.;Trcka, Daniel;Wrana, Jeff;Wu, James;Whyne, Cari M.. And the article was included in Scientific Reports in 2022.Reference of 61-73-4 This article mentions the following:

The lack of therapeutic options to fight Covid-19 has contributed to the current global pandemic. Despite the emergence of effective vaccines, development of broad-spectrum antiviral treatment remains a significant challenge, in which antimicrobial photodynamic therapy (aPDT) may play a role, especially at early stages of infection. aPDT of the nares with methylene blue (MB) and non-thermal light has been successfully utilized to inactivate both bacterial and viral pathogens in the perioperative setting. Here, we investigated the effect of MB-aPDT to inactivate human betacoronavirus OC43 and SARS-CoV-2 in vitro and in a proof-of-principle COVID-19 clin. trial to test, in a variety of settings, the practicality, tech. feasibility, and short-term efficacy of the method. aPDT yielded inactivation of up to 6-Logs in vitro, as measured by RT-qPCR and infectivity assay. From a photo-physics perspective, the in vitro results suggest that the response is not dependent on the virus itself, motivating potential use of aPDT for local destruction of SARS-CoV-2 and its variants. In the clin. trial we observed variable effects on viral RNA in nasal-swab samples as assessed by RT-qPCR attributed to aPDT-induced RNA fragmentation causing falsely-elevated counts. However, the viral infectivity in clin. nares swabs was reduced in 90% of samples and undetectable in 70% of samples. This is the first demonstration based on quant. clin. viral infectivity measurements that MB-aPDT is a safe, easily delivered and effective front-line technique that can reduce local SARS-CoV-2 viral load. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Reference of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Reference of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Potent Non-Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors from Genetic Engineering of Streptomyces hygroscopicus was written by Menzella, Hugo G.;Tran, Thomas-Toan;Carney, John R.;Lau-Wee, Janice;Galazzo, Jorge;Reeves, Christopher D.;Carreras, Christopher;Mukadam, Sophie;Eng, Sara;Zhong, Ziyang;Timmermans, Pieter B. M. W. M.;Murli, Sumati;Ashley, Gary W.. And the article was included in Journal of Medicinal Chemistry in 2009.SDS of cas: 34662-36-7 This article mentions the following:

Inhibition of the protein chaperone Hsp90 is a promising new approach to cancer therapy. We describe the preparation of potent non-benzoquinone ansamycins. One of these analogs, generated by feeding 3-amino-5-chlorobenzoic acid to a genetically engineered strain of Streptomyces hygroscopicus, shows high accumulation and long residence time in tumor tissue, is well-tolerated upon i.v. dosing, and is highly efficacious in the COLO205 mouse tumor xenograft model. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7SDS of cas: 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Studies on the novel pyridine sulfide containing SDH based heterocyclic amide fungicide was written by Hua, Xuewen;Liu, Wenrui;Su, Yanyan;Liu, Xinghai;Liu, Jingbo;Liu, Nannan;Wang, Guiqing;Jiao, Xueqin;Fan, Xiaoyi;Xue, Chenmeng;Liu, Yi;Liu, Ming. And the article was included in Pest Management Science in 2020.HPLC of Formula: 59237-53-5 This article mentions the following:

BACKGROUND : Succinate dehydrogenase (SDH) has been identified as one of the most significant targets for fungicide discovery. To date, 23 com. SDH inhibitor (SDHI) fungicides have been approved for plant protection since the first launch of carboxin in 1966, and extensively applied to combat destructive plant fungi. RESULTS : In this project, 20 novel pyridine sulfide derivatives containing SDH-based heterocyclic amide fungicide were designed, synthesized, and characterized by proton NMR (¹H-NMR), carbon-13 (¹³C)-NMR and high-resolution mass spectrometry (HRMS). In vitro fungicidal activity experiment, the target compound I-1 displayed excellent inhibitory rates against the common agricultural pathogens with half maximal effective concentration (EC₅₀) values of 5.2 to 39.8μg mL^-1. The in vivo fungicidal activities demonstrated that the compound I-1 could effectively prevent Botrytis cinerea from infecting tomato and cucumber leaves with the preventative rates of 67% and 50%. The mitochondrial membrane potential detection, SDH enzyme assay and the mol. docking simulation revealed that the mechanism of action of the compound I-1 and the relevant interactions with the target enzyme may be similar to those of the control fluopyram. CONCLUSION : The biol. activity screening and validation of mechanism of action indicated that the compound I-1 could be identified as a potential SDH inhibitor for further study. 2020 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5HPLC of Formula: 59237-53-5).

Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 59237-53-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Identification of an aminothiazole series of RORβ modulators was written by Patouret, Remi;Doebelin, Christelle;Garcia-Ordonez, Ruben D.;Chang, Mi Ra;Ruiz, Claudia;Cameron, Michael D.;Griffin, Patrick R.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.HPLC of Formula: 1711-11-1 This article mentions the following:

Crystallog. has identified stearic acid, ALRT 1550 and ATRA as ligands that bind RORβ, however, none of these mols. represent good starting points to develop optimized small mol. modulators. Recently, I was identified as a potent dual RORβ and RORγ inverse agonist with no activity towards RORα (Fig. 1). To the knowledge, this is one of only two small mol. RORβ inverse agonists identified in the primary literature from a tractable chem. series and represents an ideal starting point from which to design RORβ-selective modulators. Herein the authors describe the SAR optimization efforts that led to a series of potent neutral antagonists of RORβ. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Molecular sieving through ‘layer-by-layer’ self-assembly of polyelectrolytes and highly crosslinked graphene oxide was written by Maiti, Subhasish;Bose, Suryasarathi. And the article was included in Functional Composite Materials in 2022.Electric Literature of C16H18ClN3S This article mentions the following:

Lack of access to potable water and abating levels of ground water level demands the reuse of unconventional water sources after remediating it in a sustainable way. In this context, purifying brackish, land and sea water seems a feasible solution to the ever-growing population. In this work, a novel composite membrane was fabricated by ‘layer-by-layer’ self-assembly of poly-dopamine (PDA) and polystyrene sulfonate (PSS) supported on a highly crosslinked graphene oxide (GO) membrane to sieve ions to purify contaminated water as well as enhance the resistance towards chlorine. This GO membrane was sandwiched between layers of various nanoporous polyvinylidene difluoride (PVDF) membranes obtained by selectively etching out the PMMA component from the demixed blends. The blend membranes were designed following the melt-extrusion process and subsequent quenching to facilitate confined crystallization of PVDF and selective etching of PMMA. The membranes with different pore sizes were tuned on varying the composition in blends and a gradient in microstructure was achieved by stitching the membranes. Pure water flux, salt rejection, dye removal, and antibacterial activity were performed to study the membrane’s efficiency. The GO membrane was chem. crosslinked with methylenediamine to impart dimensional stability and to enhance rejection efficiency through the nanoslits that GO offers. Besides effective rejection, the sandwiched membrane was modified with ‘layer-by-layer’ self-assembly of polyelectrolytes on the surface to improve the chlorine tolerance performance. This strategy resulted in an excellent salt (about 95% and 97% for monovalent and divalent ion, resp.) and dye rejection (100% for both cationic and anionic dye), besides facilitating excellent chlorine tolerance performance. Moreover, this modified membrane showed superior antifouling properties (flux recovery ratio is more than 90%) and excellent antibacterial performance (near about 3 log reduction). Thus the concept of using layer-by-layer self-assembly of polycations (PDA) and polyanions (PSS) onto a hierarchical chem. modified GO sandwiched PVDF membrane proved to be a productive strategy to purify contaminated water. Thus the membrane can be a potential candidate for domestic as well as industrial application. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Electric Literature of C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Practically Unified Electrochemical Strategy for Ni-Catalyzed Decarboxylative Cross-Coupling of Aryl Trimethylammonium Salts was written by Kong, Xianqiang;Chen, Yiyi;Chen, Xiaohui;Lu, Zheng-Xuan;Wang, Wei;Ni, Shao-Fei;Cao, Zhong-Yan. And the article was included in Organic Letters in 2022.SDS of cas: 698-01-1 This article mentions the following:

By merging electrocatalysis and nickel catalysis, a unified strategy was successfully applied for preparing aryl ketones ArC(O)Ph [Ar = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.], amides ArC(O)NR¹R² [Ar = Ph, 4-ClC₆H₄, 4-MeC₆H₄, etc.; R¹ = R² = Me, Et; R¹R² = CH₂(CH₂)₂CH₂, CH₂CH₂OCH₂CH₂], esters ArC(O)OR [Ar = Ph, 2-MeC₆H₄, 4-FC₆H₄, etc.; R = Me, Et] or aldehydes ArCHO [Ar = Ph, 4-MeC₆H₄, 4-PhC₆H₄, etc.] via decarboxylative cross-coupling of four types of α-oxocarboxylic acids and their derivatives with aryl trimethylammonium salts under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1SDS of cas: 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics