Month: January 2023

Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives was written by Cheng, Pi;Zhang, Quan;Ma, Yun-Bao;Jiang, Zhi-Yong;Zhang, Xue-Mei;Zhang, Feng-Xue;Chen, Ji-Jun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Application of 18437-66-6 This article mentions the following:

A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepines were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. I [R = CH₂CH₂OH] showed IC₅₀ of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, resp., which were 10 times higher than that of its analog I [R = H] and led to better selective index (SI) values (SI = 23.2 and 3.4, resp.). In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and characterization of ladder-like copolymethyl-epoxysilsesquioxane was written by Cao, Ming;Li, Ze;Zhang, Yong;Xie, Ping;Dai, Daorong;Zhang, Rongben;Lin, Yuhui;Chung, Neal Tai-shung. And the article was included in Reactive & Functional Polymers in 2000.Reference of 12083-92-0 This article mentions the following:

A new kind of copolymethyl-epoxysilsesquioxane (CPMES) was synthesized for the first time by a hydrosilation reaction of allyl glycidyl ether (AGE) with the ladder-like polymethylhydrosilsesquioxane (Me-H-T) in the presence of dicyclopentadienylplatinum dichloride (Cp₂PtCl₂) as catalyst. The graft polymer was characterized by IR spectroscopy, ¹H-NMR, ²⁹Si-NMR, x-ray diffraction (XRD), gel-permeation chromatog. (GPC), vapor pressure osmometry (VPO), thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC). CPMES possesses good solubility in organic solvents, and a greatly improved thermostability compared with polymethyl-epoxysiloxane with a single backbone. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Reference of 12083-92-0).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 12083-92-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanism of oxidation of some active methylene compounds by N-chlorosaccharin in acetic acid-water medium. A kinetic study was written by Khan, M. U.;Nigam, S. K.;Gupta, O. P.;Tiwari, A. K. S.;Parihar, S. S.;Nigam, A.. And the article was included in Oxidation Communications in 1999.Related Products of 14070-51-0 This article mentions the following:

Oxidation of MeCOCH₂CO₂Et and CH₂(CO₂Et)₂ by N-chlorosaccharin in aqueous AcOH was studied. This reaction exhibits 1st-order dependence on both [oxidant] and [substrate]. The reaction is acid catalyzed. The effect of solvent on the reaction kinetics was also examined, as was the effect of ionic strength of the medium. The reaction rate was retarded by the addition of saccharin. The stoichiometry of the oxidation is 1:2, which shows the formation of a transitory complex between the enolic form of the substrate and the oxidant. The effect of temperature on reaction rate was also studied, and the thermodn. parameters were evaluated. Taking into account all the observed kinetic data, a plausible mechanism was described and a suitable rate law was derived. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Related Products of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Elucidating dynamic behavior of synthetic supramolecular polymers in water by hydrogen/deuterium exchange mass spectrometry was written by Lou, Xianwen;Schoenmakers, Sandra M. C.;van Dongen, Joost L. J.;Garcia-Iglesias, Miguel;Casellas, Nicolas M.;Fernandez-Castano Romera, Marcos;Sijbesma, Rint P.;Meijer, E. W.;Palmans, Anja R. A.. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2021.Electric Literature of C19H15Cl This article mentions the following:

A comprehensive understanding of the structure, self-assembly mechanism,and dynamics of one-dimensional supramol. polymers in water is essentialfor their application as biomaterials. Although a plethora of techniques areavailable to study the first two properties, there is a paucity i possibilities to study dynamic exchange of monomers between supramol. polymers in solution We recently introduced hydrogen/deuterium exchange mass spectrometry (HDX-MS) to characterize the dynamic nature of synthetic supramol. polymers with only a minimal perturbation of the chem. structure was introduced. To further expand the application of this powerful technique some essential exptl. aspects was reaffirmed and the technique was applied to a diverse library of assemblies. HDX-MS was widely applicable if there are exchangeable hydrogen atoms protected from direct contact with the solvent and if the monomer concentration was sufficiently high to ensure the presence of supramol. polymers during dilution In addition, it was demonstrated that the kinetic behavior as probed by HDX-MS was influenced by the internal order within the supramol. polymers and by the self-assembly mechanism. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Electric Literature of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sulfonyl transfer reactions: solvolysis of arenesulfonyl chlorides in aqueous trifluoroethanol was written by Forbes, Rowena M.;Maskill, H.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1991.Product Details of 63624-28-2 This article mentions the following:

Activation parameters for the solvolysis in aqueous trifluoroethanol of arenesulfonyl chlorides with electron-supplying substituents have been determined; the results are not in accord with earlier proposals that such compounds react by an S_N1 mechanism. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Product Details of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Associations between a mixture of phenols and phthalates and child behaviour in a French mother-child cohort with repeated assessment of exposure was written by Guilbert, Ariane;Rolland, Matthieu;Pin, Isabelle;Thomsen, Cathrine;Sakhi, Amrit K.;Sabaredzovic, Azemira;Slama, Remy;Guichardet, Karine;Philippat, Claire. And the article was included in Environment International in 2021.SDS of cas: 101-20-2 This article mentions the following:

Synthetic phenols and phthalates can interfere with biol. pathways involved in brain development. Despite the high within-subject temporal variability of urinary concentrations observed for their metabolites, studies investigating effects of phenols and phthalates on child behavior often relied on a limited number of spot biospecimens to assess exposure. Besides, the majority did not consider mixture effects. To study the combined effect of prenatal exposure to synthetic phenols and phthalates on child behavior using repeated exposure measurements. We assessed concentrations of 12 phenols, 13 phthalate and 2 non-phthalate plasticizer metabolites in within-subject pools of multiple urine samples (median = 21 samples per individual pool) collected at two distinct time points during pregnancy in 416 mother-child pairs from the French SEPAGES cohort. Child behavior was evaluated at two years using the Child Behavior Checklist 1.5-5 (CBCL). Associations between a mixture of biomarkers of exposure and externalizing and internalizing behavior scores were studied using adjusted Weighted Quantile Sum (WQS) regressions with a repeated holdout validation (100 repetitions). The pos. WQS indexes were associated with both the externalizing and internalizing behavior scores in the whole population, indicating greater risk of behavioral problems. Stratification for child sex suggested stronger associations in girls than boys. On average, girls externalizing and internalizing scores increased by 3.67 points (95% CI: 1.24, 6.10) and 2.47 points (95%CI: 0.60, 4.33) resp., for an increase of one tertile in the WQS index, compared with 1.70 points (95%CI: -0.42, 3.81) and 1.17 points (95%CI: -0.50, 2.84) in boys. Main contributors for the associations observed in girls were bisphenol A (weight of 18%), triclosan (17%) and monoethyl phthalate (MEP, 15%) for the externalizing score and MEP (19%), mono-benzyl phthalate (MBzP, 19%) and mono-Bu phthalate (MnBP, 16%) for the internalizing score. Our results suggest adverse associations between in utero exposure to a mixture of phenols and phthalates and child behavior, mainly in girls. Public health consequences may be substantial due to the widespread exposure of the population to these compounds In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2SDS of cas: 101-20-2).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 101-20-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel synthesis of 4H-1,4-benzoxazines was written by Kudo, Noriaki;Furuta, Satoru;Sato, Kazuo. And the article was included in Chemical & Pharmaceutical Bulletin in 1996.Product Details of 85953-29-3 This article mentions the following:

The reaction of Me 2-chloro-5-ethoxycarbonylamino-4-fluorobenzoate (I) and 1-bromo-3,3-dimethyl-2-butanone in the presence of 2.2 equiv of LiN(SiMe₃)₂ afforded the 4H-1,4-benzoxazine II in good yield, instead of the expected 4-oxazolin-2-one III. Similar preparations of 5 addnl. benzoxazines are described. The generality of the reaction and the mechanism are discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3Product Details of 85953-29-3).

Methyl 2-chloro-4-fluorobenzoate (cas: 85953-29-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 85953-29-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-pot synthesis of N,N-dimethylanilines from nitroarenes with skeletal Cu as chemoselective catalyst was written by Rong, Zeming;Zhang, Wenjun;Zhang, Peng;Sun, Zhuohua;Lv, Jinkun;Du, Wenqiang;Wang, Yue. And the article was included in Catalysis Communications in 2013.Electric Literature of C8H10ClN This article mentions the following:

A range of N,N-dimethylanilines were synthesized with excellent yields in one-pot by the hydrogenation and alkylation of nitro arenes with H₂ and CH₂O over quenched skeletal Cu catalyst, which provides a facile, economical, and environmentally benign alternative methodol. for C-N bonds formation. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Electric Literature of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nitroacenaphthene as a New Photocatalyst for the Synthesis of Sulfonyl Amidines was written by Jian, Yong;Chen, Ming;Yang, Chao;Xia, Wujiong. And the article was included in Synthesis in 2019.SDS of cas: 777-44-6 This article mentions the following:

A small mol., namely nitroacenaphthene, is reported for the first time as a recyclable visible-light photocatalyst for the construction of the C=N bond from sulfonyl azides RS(O)₂N₃ (R = Pr, 4-bromophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) and amines R¹N(R²)(R³) (R¹ = H, Me, Et, n-Pr; R² = Et, n-Pr, i-Pr, n-Bu; R³ = Me, Et, n-Pr, i-Pr, n-Bu). This scalable, site-selective protocol provides a convenient way to access various sulfonyl amidines (E/Z)-RS(O)N=CHN(R²)(R³) under mild conditions. Two reaction pathways are proposed according to different transformation patterns. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6SDS of cas: 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of N-phenylsulfonamide derivatives and investigation of some esterase enzymes inhibiting properties was written by Akin Kazancioglu, Elif;Senturk, Murat. And the article was included in Bioorganic Chemistry in 2020.Electric Literature of C7H4ClF3O2S This article mentions the following:

In this study, synthesis of nine N-phenylsulfonamide derivatives I [R = Me, 4-methoxyphenyl, 4-fluorophenyl, 2-thiophenyl, etc.] was designed by starting from aniline, which was the simplest aromatic amine. These compounds I were obtained in yields between 69 and 95%. Inhibitory properties of synthesized compounds I on carbonic anhydrase I (CA I), CA II isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. The compound I [R = 2-naphthyl] for CA I, AChE and BChE, 2 for CA II showed a very active inhibition profile (KI 45.7 ± 0.46 for CA I, 33.5 ± 0.38 nM for CA II, 31.5 ± 0.33 nM for AChE and 24.4 ± 0.29 nM for BChE). The results indicate that these N-phenyl-sulfonamide derivatives I were potent CA and cholinesterases and new potential drugs. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics