Month: January 2023

Discovery of Dithioacetal Derivatives Containing Sulfonamide Moiety of Novel Antiviral Agents by TMV Coat Protein as a Potential Target was written by Yang, Yuyuan;Zhang, Jian;Li, Xiangyang;He, Fangcheng;Wu, Rong;Hu, Deyu;Song, Baoan. And the article was included in ACS Omega in 2020.Related Products of 777-44-6 This article mentions the following:

Tobacco mosaic virus coat protein (TMV CP) plays an important role in viral replication, translation, and intracellular and intercellular movements. Thus, TMV CP could be regarded as a potential target for antiviral agents. In this study, in order to find out whether dithioacetal derivatives act on the CP target, a series of dithioacetal derivatives containing sulfonamide moiety was first designed and synthesized. Bioassay results demonstrated that three of the compounds exhibited excellent activities against TMV, with half-maximal effective concentrations (EC₅₀) of the curative, protective, and inactivate activities being 183.0 ± 3.2, 252.3 ± 2.6, and 63.8 ± 1.2μg/mL, 270.6 ± 3.7, 249.7 ± 3.5, and 57.7 ± 1.4μg/mL, and 329.5 ± 1.5, 269.2 ± 3.7, and 48.1 ± 2.0μg/mL, which were higher than those for the control agents ningnanmycin (331.0 ± 2.8, 271.0 ± 2.8, and 77.4 ± 1.3μg/mL, resp.) and d2 (471.5 ± 1.4, 447.2 ± 2.1, and 91.7 ± 1.8μg/mL, resp.). Transmission electron microscopy showed that the particle morphol. of TMV was destroyed by I, and microscale thermophoresis (MST) showed that I bonded to CP with a dissociation constant (K_d) of 9.7 ± 1.7μM. Then, mol. docking and MST further illustrated that I had a weak binding affinity with the TMV mutant protein (K_d = 561.3 ± 83.2μM). Thus, we deduced that the dithioacetal derivative I may inhibit TMV activity by binding TMV CP. This work provides some new insights for the design and optimization of anti-TMV agents. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Related Products of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics and mechanistic approach of N-chlorosaccharin oxidation of some aliphatic aldehydes was written by Khan, M. U.;Verma, J. K.;Nigam, S. K.;Parihar, S. S.;Dwivedi, H. P.. And the article was included in Oxidation Communications in 1998.Application of 14070-51-0 This article mentions the following:

The kinetic studies of N-chlorosaccharin (NCSA) oxidation of acetaldehyde and propionaldehyde have been reported in aqueous acetic acid medium. The reactions follow identical kinetics, being first order in each NCSA, and 1 to 0 order with respect to substrate and [H⁺]. A pos. effect on the oxidation rate is observed for solvent whereas saccharin exhibited a neg. trend. The ionic strength does not influence the oxidation rate. Various activation parameters have been evaluated. The products of the reactions were identified as the corresponding acids. A suitable scheme of mechanism consistent with the exptl. results has been proposed. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Application of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An Atom-Economical Method for the Formation of Amidopyrroles Exploiting the Self-Assembled Resorcinarene Capsule was written by La Manna, Pellegrino;Talotta, Carmen;De Rosa, Margherita;Soriente, Annunziata;Gaeta, Carmine;Neri, Placido. And the article was included in Organic Letters in 2020.HPLC of Formula: 620-19-9 This article mentions the following:

Here is reported the first example of an organocatalyzed coupling between pyrrole and isocyanates in a nanoconfined space. The hexameric resorcinarene capsule C is able to catalyze the direct coupling between isocyanates and pyrroles to give amidopyrroles with excellent yields and selectivities. The reaction catalyzed by C prevents the use of expensive and poorly atom-economical reagents. As in natural enzymes, the cavity of C is able to discriminate between isomeric substrates. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9HPLC of Formula: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).HPLC of Formula: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship and hypoglycemic activity of tricyclic matrines with advantage of treating diabetic nephropathy was written by Tang, Sheng;Wang, Can;Li, Ying-Hong;Niu, Tian-Yu;Zhang, Yuan-Hui;Pang, Yu-Dong;Wang, Yan-Xiang;Kong, Wei-Jia;Song, Dan-Qing. And the article was included in European Journal of Medicinal Chemistry in 2020.Electric Literature of C7H4ClF3O2S This article mentions the following:

Forty-three tricyclic matrinic derivatives with a unique scaffold were prepared and evaluated for their stimulation effects on glucose consumption in HepG2 cells. The structure-activity relationship was systematically elucidated for the first time. Among them, compound 17a(I) exhibited the most promising potency, and dose-dependently increased glucose consumption in L6 myotubes. It significantly lowered blood glucose, glucosylated Hb and AGE level, and improved glucose tolerance and insulin resistance in KK-Ay mice as well. More importantly, 17a effectively ameliorated diabetic nephropathy (DN), as indicated by the improvement of renal function and pathol. changes, and decrease of urinary protein. Furthermore, 17a could induce glycolysis but suppressed aerobic oxidation of glucose, in a similar mechanism to Metform. Our results indicated that in addition to hyperglycemia, 17a may be developed to treat diabetic complication such as DN. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bis(cyclopentadienyl)methane-bridged dinuclear complexes. IV. Synthesis, structure, and reactivity of dinuclear rhodium and iridium complexes in the oxidation state +I and +III with the bis(cyclopentadienyl)methane dianion as bridging ligand was written by Werner, Helmut;Treiber, Monja;Nessel, Angelika;Lippert, Ferdinand;Betz, Peter;Krueger, Carl. And the article was included in Chemische Berichte in 1992.Recommanded Product: 39722-81-1 This article mentions the following:

The rhodium compounds [CH₂(C₅H₄)₂][Rh(L)(C₂H₄)]₂ [L = CO, P(CHMe₂)₃ (PiPr₃) (I)] were prepared from [RhCl(L)(C₂H₄)]₂ and CH₂(C₅H₄)₂Li₂ in 92 and 73% yield, resp. The reaction of I (L = PiPr) with X₂ (Cl₂, Br₂, and I₂) led to the almost quant. formation of the dihalo derivatives [CH₂(C₅H₄)₂][RhX₂(PiPr₃)]₂ (II), which on treatment with excess NaBH₄ and methanol gave the dihydride [CH₂(C₅H₄)₂][RhH₂(PiPr₃)]₂ (III). From [RhCl(C₈H₁₄)₂]₂, PiPr₃, and CH₂(C₅H₅)₂ [CH₂(C₅H₄)₂][RhH(Cl)(PiPr₃)₂ was obtained. Protonation of III with CF₃CO₂H in the presence of NH₄PF₆ gave the PF₆ salt of the hydrido-bridged cation {[CH₂(C₅H₄)₂][RhH(PiPr₃)]₂(μ-H)}⁺ of which the crystal structure was determined In solution, fluxional behavior of the cation was observed The di-Me compound [CH₂(C₅H₄)₂][Rh(CH₃)₂(PiPr₃)]₂ prepared from II and LiCH₃ or CH₃MgI in 80% yield, reacted with CF₃CO₂H at -78° to give the trifluoroacetato derivative IV; this on treatment with P(OMe)₃ and dmpe formed dicationic complexes. The dinuclear iridium compounds [CH₂(C₅H₄)₂][Ir(olefin)₂]₂ and [CH₂(C₅H₄)₂][Ir(C₈H₁₂)]₂ were prepared from [IrCl(L)₂]₂ and CH₂(C₅H₄)₂Li₂ and used for the synthesis of {[CH₂(C₅H₄)₂][IrX₂]₂}_n. V (X = Br, iodo) served as starting materials for the preparation of the dinuclear derivatives [CH₂(C₅H₄)₂][IrX₂(L)]₂ and {[CH₂(C₅H₄)₂][IrBr₂]₂(μ-dipy)} and finally also for the dihydrido complex [CH₂(C₅H₄)₂][IrH₂(PiPr₃)]₂. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1Recommanded Product: 39722-81-1).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 39722-81-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sequential Selective C-H and C(sp³)-⁺P Bond Functionalizations: An Entry to Bioactive Arylated Scaffolds was written by Babu, K. Naresh;Massarwe, Fedaa;Shioukhi, Israa;Masarwa, Ahmad. And the article was included in Angewandte Chemie, International Edition in 2021.SDS of cas: 620-19-9 This article mentions the following:

Organophosphonium salts containing C(sp3)-+P bonds are among the most utilized reagents in organic synthesis for constructing C-C double bonds. However, their use as C-selective electrophilic groups is rare. Here, authour explore an efficient and general transition-metal-free method for sequential chemo- and regioselective C-H and C(sp³)-+P bond functionalizations. In the present study, C-H alkylation resulting in the synthesis of benzhydryl triarylphosphonium salts was achieved by one-pot, four-component cross-coupling reactions of simple and com. available starting materials. The utility of the resulting phosphonium salt building blocks was demonstrated by the chemoselective post-functionalization of benzylic C(sp³)-+PPh³ groups to achieve aminations, thiolations, and arylations. In this way, benzhydrylamines, benzhydrylthioethers, and triarylmethanes, structural motifs that are present in many pharmaceuticals and agrochems., are readily accessed. These include the synthesis of two anticancer agents from simple materials in only two to three steps. Addnl., a protocol for late-stage functionalization of bioactive drugs has been developed using benzhydrylphosphonium salts. This new approach should provide novel transformations for application in both academic and pharmaceutical research. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9SDS of cas: 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A study on the uptake of methylene blue by biodegradable and eco-friendly carboxylated starch grafted polyvinyl pyrrolidone was written by Haq, Fazal;Farid, Arshad;Ullah, Naveed;Kiran, Mehwish;Khan, Rizwan Ullah;Aziz, Tariq;Mehmood, Sahid;Haroon, Muhammad;Mubashir, Muhammad;Bokhari, Awais;Chuah, Lai Fatt;Show, Pau Loke. And the article was included in Environmental Research in 2022.Recommanded Product: 61-73-4 This article mentions the following:

This study is based on the removal of methylene blue (MB) from aqueous solution by cost effective and biodegradable adsorbent carboxymethyl starch grafted polyvinyl pyrolidone (Car-St-g-PVP). The Car-St-g-PVP was synthesized by grafting vinyl pyrolidone onto carboxymethyl starch by free radical polymerization reaction. The structure and different properties of Car-St-g-PVP were determined by 1H NMR, FT-IR, XRD, TGA and SEM. A series of batch experiments were conducted for the removal of MB, The adsorption affecting factors such as temperature, contact time, initial concentration of MB dye, dose of Car-St-g-PVP and pH were studied in detail. The other parameters like the thermodn. study, kinetics and isothermal models were fitted to the exptl. data. The results showed that pseudo 2nd order kinetics and Langmuir ‘s adsorption isotherms were best fitted to exptl. data with regression coefficient R2 viz. 0.99 and 0.97. The kinetic study showed that the adsorption mechanism favored chemisorption. The Gibbs free energy (ΔG°) for the adsorption process was found to be -7.31 kJ/mol, -8.23 kJ/mol, -9.00 kJ/mol and -10.10 kJ/mol at 25°C, 35°C, 45°C and 55°C resp. The neg. values of ΔG° suggested the spontaneous nature of the adsorption process. Similarly, the pos. values of entropy (ΔS°) and enthalpy (ΔH°) 91.27 J/k.mol and 19.90 kJ/mol showed the increasing randomness and endothermic nature of the adsorption process. The value of separation factor (RL) was found to be less than one (RL < 1), which supported the feasibility of the adsorption process. The maximum MB removal percentage (% R) was found to be 98.6%. So, these findings show that Car-St-g-PVP can be meritoriously used for the treatment of MB from wastewater. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Recommanded Product: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones was written by Abdel-Aziz, Alaa A.-M.;El-Azab, Adel S.;El-Subbagh, Hussein I.;Al-Obaid, Abdulrahman M.;Alanazi, Amer M.;Al-Omar, Mohamed A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Reference of 63624-28-2 This article mentions the following:

Mono(arylsulfonyl) and bis(arylsulfonyl) dimethoxyimidazolidinones I [R = PhSO₂, 2-naphthylsulfonyl, 4-MeC₆H₄SO₂, 4-MeOC₆H₄SO₂, 4-ClC₆H₄SO₂, 2,4-(MeO)₂C₆H₃SO₂, 2,4-Cl₂C₆H₄SO₂, 2,4,6-Me₃C₆H₂SO₂, 2,4,6-(Me₂CH)₃C₆H₂SO₂; R¹ = H, R] were prepared as cyclic analogs of the antitumor agent sulofenur and tested for their antitumor activity in a variety of human cancer cell lines. Bromination of 1,3-diacetyl-2-imidazolone followed by treatment with DIPEA and methanol gave I (R = H; R¹ = MeCO); sulfonylation followed by cleavage of the remaining acetyl group yielded I [R = PhSO₂, 2-naphthylsulfonyl, 4-MeC₆H₄SO₂, 4-MeOC₆H₄SO₂, 4-ClC₆H₄SO₂, 2,4-(MeO)₂C₆H₃SO₂, 2,4-Cl₂C₆H₄SO₂, 2,4,6-Me₃C₆H₂SO₂, 2,4,6-(Me₂CH)₃C₆H₂SO₂; R¹ = H], while cleavage of the remaining acetyl group followed by disulfonylation gave I [R = R¹ = PhSO₂, 2-naphthylsulfonyl, 4-MeC₆H₄SO₂, 4-MeOC₆H₄SO₂, 4-ClC₆H₄SO₂, 2,4-(MeO)₂C₆H₃SO₂, 2,4-Cl₂C₆H₄SO₂, 2,4,6-Me₃C₆H₂SO₂, 2,4,6-(Me₂CH)₃C₆H₂SO₂]. Bis(arylsulfonyl) dimethoxyimidazolidinones were more active against cancer cells than the corresponding mono(arylsulfonyl) dimethoxyimidazolidinones, with bis(arylsulfonyl) dimethoxyimidazolidinones showing particular activity against lung and kidney cancer cell lines. I (R = R¹ = 4-ClC₆H₄) showed remarkable broad-spectrum antitumor activity. The structure of I [R = 2,4-(MeO)₂C₆H₃SO₂; R¹ = H] was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient, continuous N-Boc deprotection of amines using solid acid catalysts was written by Wu, Jing;Zheng, Chunming;Li, Bryan;Hawkins, Joel M.;Scott, Susannah L.. And the article was included in Reaction Chemistry & Engineering in 2021.Related Products of 18437-66-6 This article mentions the following:

The use of simple solid Bronsted acid catalysts to achieve continuous N-Boc deprotection of amines, e.g., tert-Bu 2-oxopiperidine-1-carboxylate without addnl. workup steps has been described. Using THF as the solvent, H-BEA zeolite affords high yields of a variety of aromatic and aliphatic amines, e.g., 2-piperidinone often in residence times of less than a minute at 140°C. The same catalyst/solvent combination is ineffective in batch conditions, due to the much lower temperature of refluxing THF. Boc-protected p-chloroaniline was deprotected with a throughput of 18 mmol p-chloroaniline per h per g_cat, sustained over 9 h. The active sites of the zeolite do not appear to be directly associated with the Al framework substitution in the micropores, since partially ion-exchanged Na/H-BEA shows activity similar to H-BEA. The strong Bronsted acid sites (framework [Si(OH)Al]), are likely poisoned by the amine product. Moderate Bronsted acid sites associated with silanol defects near Al on or near the external surface (and not susceptible to Na+-exchange) are presumably the active sites, since they are not poisoned even by more basic aliphatic amines. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Related Products of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

General catalytic methylation of amines with formic acid under mild reaction conditions was written by Sorribes, Ivan;Junge, Kathrin;Beller, Matthias. And the article was included in Chemistry – A European Journal in 2014.Category: chlorides-buliding-blocks This article mentions the following:

A general catalytic protocol for the methylation of amines was developed applying, for the first time, formic acid as the C₁ building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines was converted to the corresponding tertiary amines including [N-¹³C]-labeled drugs in good to excellent yields under mild conditions. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Category: chlorides-buliding-blocks).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics