Month: January 2023

Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist was written by Schnute, Mark E.;Wennerstal, Mattias;Alley, Jennifer;Bengtsson, Martin;Blinn, James R.;Bolten, Charles W.;Braden, Timothy;Bonn, Tomas;Carlsson, Bo;Caspers, Nicole;Chen, Ming;Choi, Chulho;Collis, Leon P.;Crouse, Kimberly;Farnegardh, Mathias;Fennell, Kimberly F.;Fish, Susan;Flick, Andrew C.;Goos-Nilsson, Annika;Gullberg, Hjalmar;Harris, Peter K.;Heasley, Steven E.;Hegen, Martin;Hromockyj, Alexander E.;Hu, Xiao;Husman, Bolette;Janosik, Tomasz;Jones, Peter;Kaila, Neelu;Kallin, Elisabet;Kauppi, Bjorn;Kiefer, James R.;Knafels, John;Koehler, Konrad;Kruger, Lars;Kurumbail, Ravi G.;Kyne, Robert E.;Li, Wei;Lofstedt, Joakim;Long, Scott A.;Menard, Carol A.;Mente, Scot;Messing, Dean;Meyers, Marvin J.;Napierata, Lee;Noteberg, Daniel;Nuhant, Philippe;Pelc, Matthew J.;Prinsen, Michael J.;Rhonnstad, Patrik;Backstrom-Rydin, Eva;Sandberg, Johnny;Sandstrom, Maria;Shah, Falgun;Sjoberg, Maria;Sundell, Aron;Taylor, Alexandria P.;Thorarensen, Atli;Trujillo, John I.;Trzupek, John D.;Unwalla, Ray;Vajdos, Felix F.;Weinberg, Robin A.;Wood, David C.;Xing, Li;Zamaratski, Edouard;Zapf, Christoph W.;Zhao, Yajuan;Wilhelmsson, Anna;Berstein, Gabriel. And the article was included in Journal of Medicinal Chemistry in 2018.Product Details of 1711-11-1 This article mentions the following:

The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune diseases. A small mol., inverse agonist of the receptor is anticipated to reduce production of IL-17, a key proinflammatory cytokine. Through a high-throughput screening approach, authors identified a mol. displaying promising binding affinity for RORC2, inhibition of IL-17 production in Th17 cells, and selectivity against the related RORA and RORB receptor isoforms. Lead optimization to improve the potency and metabolic stability of this hit focused on two key design strategies, namely, iterative optimization driven by increasing lipophilic efficiency and structure-guided conformational restriction to achieve optimal ground state energetics and maximize receptor residence time. This approach successfully identified 3-cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide as a potent and selective RORC2 inverse agonist, demonstrating good metabolic stability, oral bioavailability, and the ability to reduce IL-17 levels and skin inflammation in a preclin. in vivo animal model upon oral administration. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Product Details of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Interlayered thin-film nanocomposite membrane with synergetic effect of COFs interlayer and GQDs incorporation for organic solvent nanofiltration was written by Li, Shuxuan;Yin, Yating;Liu, Shaoxiao;Li, Honghai;Su, Baowei;Han, Lihui;Gao, Xueli;Gao, Congjie. And the article was included in Journal of Membrane Science in 2022.Product Details of 4422-95-1 This article mentions the following:

The separation performance of current organic solvent nanofiltration (OSN) membranes are still not satisfied. In this work, an ultra-thin TpHz covalent organic frameworks (COFs) interlayer was in situ constructed in advance on polyimide substrate, then an ultra-thin polyamide separation layer incorporated with amino-functionalized graphene quantum dots (af-GQDs) was constructed via interfacial polymerization (IP). A high performance interlayered thin-film nanocomposite (iTFN) OSN membrane with integrally covalent bonding structure, ultra-thin and ultra-smooth surface was obtained after post crosslinking and activation. The effect of ultra-low concentrations for the polyamide reaction monomers, the COFs monomer Tp and the doped af-GQDs nanoparticle reveals that they could help to form a very thin (7-8 nm in thickness) and defect-free skin layer with very smooth surface (about 2.7 nm in roughness). The iTFN OSN membrane shows excellent solvent permeance and solute selectivity, with an ethanol permeance reaching 97.6 L m^-2 h^-1 MPa^-1 and an RDB rejection higher than 99%. After a 180 h long-term filtration with 100 mg L^-1 RB/DMF solution, it remained an RB rejection of higher than 99%, demonstrating its superior resistance to strong polar solvent. Our work paves a unique way for the fabrication of novel OSN membrane with both in situ constructed nanomaterials interlayer and nanomaterials incorporated in skin layer. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Product Details of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cu-Catalyzed intermolecular [3 + 3] annulation involving oxidative activation of an unreactive C(sp³)-H bond: access to pyrimidine derivatives from amidines and ketones was written by Guo, Wei;Liu, Dongqing;Liao, Jianhua;Ji, Fanghua;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Organic Chemistry Frontiers in 2017.HPLC of Formula: 18637-02-0 This article mentions the following:

A facile and efficient approach for the synthesis of various pyrimidine derivatives, e.g., I from amidines RC(NH₂)=NH (R = Me, Ph, 4-pyridyl, cyclopropyl, etc.) and ketones, e.g., 4-CH₃OC₆H₄C(O)CH₂CH₃ via a Cu-catalyzed intermol. oxidative coupling process using TEMPO/O₂ as a co-oxidant has been developed. This novel protocol features unreactive C(sp³)-H bond amination, a wide range of substrates, good functional group tolerance and mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0HPLC of Formula: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanism of radical chlorination of hydrocarbons with N-halosulfonamides. Effect of structural factors on the reaction selectivity was written by Dneprovskii, A. S.;Eliseenkov, E. V.;Osmonov, T. A.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 1998.Recommanded Product: 14070-51-0 This article mentions the following:

Radical chlorination of alkanes and their derivatives with N-halosulfonamides was studied by the method of competing reactions under conditions where H is abstracted only by sulfonylaminyl radical. The selectivity of reactions with N-halosulfonamides is intermediate between radical chlorination and bromination with mol. halogens. Radicals with captodative properties exhibit the highest selectivity. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Occurrence and partitioning of bisphenol analogues, triclocarban, and triclosan in seawater and sediment from East China Sea was written by Xie, Jiahui;Zhao, Nan;Zhang, Yingying;Hu, Hongmei;Zhao, Meirong;Jin, Hangbiao. And the article was included in Chemosphere in 2022.Formula: C13H9Cl3N2O This article mentions the following:

Bisphenol analogs (BPs), triclocarban (TCC), and triclosan (TCS) are well-known environmental endocrine disrupters. Many studies have characterized their occurrence in the freshwater environment. However, their environmental behaviors in the coastal marine environment remain poorly understood. Here, matched seawater and sediment samples were collected from East China Sea, and analyzed for 13 BPs (including halogenated derivatives of bisphenol A), TCC, and TCS. Bisphenol A (BPA; mean 23 ng/L) was the predominant BP in seawaters, followed by tetrabromobisphenol A (TBBPA; 2.3 ng/L) and bisphenol S (BPS; 2.2 ng/L). Seawater concentrations of TCS (<LOD-8.7 ng/L) were much higher (p < 0.01) than that of TCC (<LOD-0.33 ng/L). In sediments BPA was still the major BP (mean 13 ng/g dw, dry weight), followed by bisphenol F (1.6 ng/g dw) and BPS (0.69 ng/g dw). All sediment samples contained measurable TCC (0.12-6.6 ng/g dw), while TCS was occasionally detected. For the first time, this study reports the environmental occurrence of bisphenol M and 4,4′-sulfonylbis (2-aminophenol) (a first discovered BPS analog) in seawaters and sediments. Spatially, inshore seawater and sediment samples contained higher (p < 0.01) BPA and BPS concentrations, compared with offshore samples. The mean log-transformed sediment-seawater partitioning coefficients (log K_oc) ranged from 2.3 (TBBPA) to 4.0 (TCC). The log Koc values of BPA, BPS, and BPAF were lower than those previously reported in the freshwater environment. Overall, this study provides first data on the spatial distribution patterns and partitioning behaviors of BPs, TCC, and TCS in marine environment. In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Formula: C13H9Cl3N2O).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C13H9Cl3N2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and urease inhibitory activities of benzophenone semicarbazones/thiosemicarbazones was written by Arshia, Arshia;Khan, Ajmal;Khan, Khalid Mohammed;Saad, Syed Muhammad;Siddiqui, Nida Iqbal;Javaid, Sumaira;Perveen, Shahnaz;Choudhary, M. Iqbal. And the article was included in Medicinal Chemistry Research in 2016.Name: 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Twenty-five benzophenone semicarbazones and thiosemicarbazones were synthesized starting from benzophenones via hydrazones treated with different aryl isocyanates and isothiocyantes under reflux. All synthetic derivatives were evaluated for their urease inhibitory potential. A good-to-moderate inhibition trend against urease was observed with IC₅₀ values in the range of 8.7-119.5 μM, when compared with the standard thiourea (IC₅₀ = 21.2 ± 1.3 μM). One compound showed better inhibition than the standard having an IC₅₀ value of 8.7 ± 0.6 μM. Nine compounds with IC₅₀ values within the range of 26.1-43.6 μM, demonstrated good-to-moderate activities while one compound (IC₅₀ = 119.5 ± 1.6 μM) displayed very weak activity. The enzyme kinetic studies on the 2 most active compounds were performed to deduce their modes of inhibition and K_i values. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Name: 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alkyl 2-Aryl-2-thioxoethanoates and -thioates: Preparation, Dimerization, and EPR Spectra of the Corresponding Radical Anions was written by Voss, Jurgen;Sawluk, Andrzej;Lange, Gisela;Adiwidjaja, Gunadi. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2009.SDS of cas: 7476-66-6 This article mentions the following:

The title compounds were prepared by reaction of the corresponding α-halocarboxylic or α-halothiolocarboxylic esters with tetraethylammonium thiosulfate and subsequent treatment of the resulting Bunte salts with sodium hydroxide in a two-phase system. Under elimination of sulfite, the deep-blue colored thiones were generated. These labile compounds could not always be isolated from the solutions in a pure state. Instead, frequently the [2+2]-dimers (dialkyl 2,4-diaryl-1,3-dithietane-2,4-carboxylates) or other follow-up products were obtained. Nevertheless, the EPR spectra of the monomer radical anions could be recorded even if solutions of the dimers were reduced by internal electrolysis. Addnl. EPR spectra were observed in several cases, which the authors assign to the radical anions of dialkyl 2,3-diaryl-2-butene-1,4-dioate radical anions originating from electron induced sulfur extrusion of the corresponding 1,3-dithietanes. Radical trianions were observed when a 1,4-benzene-bis-α -thioxo ester or -thioxo-thiol ester was electroreduced at a more neg. electrode potential. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6SDS of cas: 7476-66-6).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 7476-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting ^V600EBRAF was written by Abdel-Maksoud, Mohammed S.;Ali, Eslam M. H.;Ammar, Usama M.;Mersal, Karim I.;Yoo, Kyung Ho;Oh, Chang-Hyun. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:

Several pyrrolo[2,3-b]pyridine-based B-RAF inhibitors are well known and some of them are currently FDA approved as anticancer agents. Based on the structure of these FDA approved ^V600EB-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent ^V600EB-RAF inhibitors. The 38 synthesized compounds were biol. evaluated for their ^V600EB-RAF inhibitory effect at single dose (10 μM). Compounds with high percent inhibition were tested to determine their IC₅₀ over ^V600EB-RAF. Compounds 34e and 35 showed the highest inhibitory effect with IC₅₀ values of 0.085 μM and 0.080 μM, resp. Headed for excessive biol. evaluation, the synthesized derivatives were tested over sixty diverse human cancer cell lines. Only compound 35(I) emerged as a potent cytotoxic agent against different panel of human cancer cell lines. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Quality Control of 3-(Trifluoromethyl)benzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold was written by Chen, Lijuan;Wang, Xiaobin;Tang, Xu;Xia, Rongjiao;Guo, Tao;Zhang, Cheng;Li, Xiangyang;Xue, Wei. And the article was included in BMC Chemistry in 2019.Product Details of 620-19-9 This article mentions the following:

penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel mols. with highly-efficient agricultural activities, a series of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were synthesized and evaluated for their antiviral activities. Antiviral bioassays indicated that some title compounds exhibited significant antiviral activity against tobacco mosaic virus (TMV). In particular, compounds 8c, 8j and 8k possessed appreciable curative activities against TMV in vivo, with half-maximal effective concentration (EC50) values of 138.5, 132.9 and 125.6 μg/mL, resp., which are better than that of ningnanmycin (207.3 μg/mL). Furthermore, the microscale thermophoresis experiments (MST) on the interaction of compound 8k with TMV coat protein (TMV CP) showed 8k bound to TMV CP with a dissociation constant of 0.97 mmol/L. Docking studies provided further insights into the interaction of 8k with the Arg90 of TMV CP. Sixteen penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were designed, synthesized, and their antiviral activities against TMV were evaluated. Antiviral bioassays indicated that some target compounds exhibited remarkable antiviral activities against TMV. Furthermore, through the MST and docking studies, we can speculate that 8k inhibited the virulence of TMV by binding Arg90 in TMV CP. These results indicated that this kind of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold could be further studied as potential alternative templates in the search for novel antiviral agents. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Product Details of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The Willgerodt reaction in the heterocyclic series. II. Some compounds of the 2- and 3-thienyl series was written by Blanchette, Joseph A.;Brown, Ellis V.. And the article was included in Journal of the American Chemical Society in 1951.Recommanded Product: 2,5-Dichlorothiophene-3-carboxylic acid This article mentions the following:

3-Methylthiophene (55 g.), 95 g. N-bromosuccinimide, and 150 cc. CCl₄ refluxed 5 hrs., filtered, and the solvent removed in vacuo yielded 70 g. 3-methyl-2-bromothiophene (I), b₁₃ 61-3°, b₁₆ 68-70°. Dry CO₂ passed 3 hrs. into the Grignard reagent from 0.64 mole I at -7° and the product decomposed with dilute H₂SO₄ yielded 59 g. 3-methyl-2-thiophenecarboxylic acid (II), m. 147-8° (from water). II (50 g.) and 200 cc. SOCl₂ refluxed 3 hrs. yielded the acid chloride, which, added in 100 cc. Et₂O to 0.36 mole Me₂Cd in an ice bath and the mixture refluxed 0.5 hr., cooled, and decomposed, yielded 43 g. 3-methyl-2-thienyl Me ketone (III), b₁₄ 98-9°. Amides from S.CR²: CR³.CR⁴:CR⁵ (I); R², R³, I, R⁴, R⁵, Amide, M.p., Yield (%), A, B; Et, Ac, H, Et, 3-acetamide, 116-17°, 52, 40; Ac, H, H, Et, 2-acetamide, 148°, 42, 55; Ac, H, H, Me, 2-acetamide (II), 143-4°, 41, 54; Ac, Me, Me, H, 2-acetamide (III), 152°, 34, 24; Ac, Me, H, H, 2-acetamide (IV), 142°, 27, 29; Me, Me, H, Ac, 5-acetamide (V), 165-6°, 40, 55; H, Ac, H, H, 3-acetamide (VI), 154-5°, 5, 13; AcCH₂, H, H, H, 2-propionamide (VII), 99-100°, 20, 28; CH₂:CH, H, H, H, 2-acetamide (VIII), 147-8°, 25, 30; CO₂H, H, H, H, 2-carboxamide (IX), 179-80°, 63, 70; CH(OH)Me, H, H, H(a), 2-acetamide (X), 147-8°, 22, 35; (a) Semicarbazone m. 193-4° (from 50% alc.-water).; 2,5-Dichloro-3-thienyl Me ketone oxidized with KOCl yielded 75% 2,5-dichloro-3-thiophenecarboxylic acid, which on dehalogenation with 5% Pd-on-C yielded 75% 3-thiophenecarboxylic acid, 30 g. of which by the procedure for III yielded 12 g. 3-thienyl Me ketone, b₂₁ 117°; semicarbazone, m. 173-4° (from 33% alc.-water). 2-Cyanothiophene (6 g.) in 20 cc. cold concentrated H₂SO₄ poured after 15 min. onto ice yielded 4 g. 2-thiophenecarboxamide, m. 179-80°. 2-Thiophenecarboxaldehyde (82 g.) in 50 cc. Et₂O added dropwise to 0.73 mole MeMgBr in an ice bath, and the mixture refluxed 0.5 hr., cooled, and poured into ice and dilute H₂SO₄ yielded 79 g. methyl-2-thienylcarbinol, b₅ 80-3°; urethan, m. 85-6° (from petr. ether). Ten g. thiophene derivative, 25 g. S, 25 cc. concentrated NH₄OH, and 30 cc. dioxane heated 11-12 hrs. at 150-60° in a sealed tube and the product evaporated to dryness and extracted with boiling water yielded (Method A) crude amide. The thiophene derivative (5 g.), 25 g. yellow NH₄ polysulfide, 3.5 g. S, and 25 cc. dioxane heated 11-12 hrs. at 150-60° yielded (Method B) crude amides. The amides crystallized from water in white plates or needles. The amides (1-2 g.) refluxed 2-3 hrs. with 70-100 cc. 25% KOH and the solution cooled and acidified with 20% HCl yielded the corresponding acids for which the m.ps. are: II, 54-5°; III, 67-8°; IV, 89-90°; V, 97-8°; VI, 79-80°; VII, 44-5°; VIII, 62-3°; IX, 128°; X, 62-3°. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Recommanded Product: 2,5-Dichlorothiophene-3-carboxylic acid).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 2,5-Dichlorothiophene-3-carboxylic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics