Month: January 2023

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase was written by Milkiewicz, Karen L.;Weinberg, Linda R.;Albom, Mark S.;Angeles, Thelma S.;Cheng, Mangeng;Ghose, Arup K.;Roemmele, Renee C.;Theroff, Jay P.;Underiner, Ted L.;Zificsak, Craig A.;Dorsey, Bruce D.. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Quality Control of 2,5-Difluorophenylacetyl chloride This article mentions the following:

Dysregulation of the anaplastic lymphoma kinase (ALK) is implicated in a variety of cancers. A series of tetrahydropyrido[2,3-b]pyrazines was constructed as ring-constrained analogs of a known aminopyridine kinase scaffold. Chem. was developed to rapidly elaborate the SAR, structural elements impacting ALK inhibitory activity were exploited, and kinase selective analogs were identified that inhibit ALK with IC₅₀ values âˆ?0 nM (enzyme) and âˆ?50 nM (cell). In the experiment, the researchers used many compounds, for example, 2,5-Difluorophenylacetyl chloride (cas: 157033-23-3Quality Control of 2,5-Difluorophenylacetyl chloride).

2,5-Difluorophenylacetyl chloride (cas: 157033-23-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 2,5-Difluorophenylacetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

(-)-2-Menthylindenyl and (-)-2-Menthyl-4,7-dimethylindenyl Complexes of Rhodium, Iridium, Cobalt, and Molybdenum was written by Schumann, Herbert;Stenzel, Oleg;Dechert, Sebastian;Girgsdies, Frank;Halterman, Ronald L.. And the article was included in Organometallics in 2001.COA of Formula: C8H16Cl2Ir2 This article mentions the following:

Optically active complexes of Rh, Ir, Co, and Mo containing the chiral, menthyl-substituted indenyl ligands (-)-2-menthylindene and (-)-2-menthyl-4,7-dimethylindene are described. Metathetic reaction of the chiral lithium salts of these indenyl systems (1, 2, resp.) with the appropriate starting materials of Rh and Ir yielded the complexes (-)-(2-menthylindenyl)Rh(COD) (3), (-)-(2-menthyl-4,7-dimethylindenyl)Rh(COD) (4), (-)-(2-menthylindenyl)Rh(C₂H₄)₂ (5), (-)-(2-menthyl-4,7-dimethylindenyl)Rh(C₂H₄)₂ (6), (-)-(2-menthylindenyl)Ir(COD) (7), (-)-(2-menthylindenyl)Ir(C₂H₄)₂ (8), (-)-(2-menthyl-4,7-dimethylindenyl)Ir(C₂H₄)₂ (9), and (-)-(2-menthyl-4,7-dimethylindenyl)Ir(COE)₂ (10). Co₂(CO)₈ and CoCl₂(dppe) react with (-)-2-menthylindenyllithium (1) yielding (-)-(2-menthylindenyl)Co(CO)₂ (11) and (+)-(2-menthylindenyl)Co(dppe) (12). (-)-Li[(2-menthylindenyl)Mo(CO)₃](THF)₂ (13), formed by transmetalation of Mo(CO)₆, is oxidized by I₂, yielding (-)-(2-menthylindenyl)Mo(CO)₃I (14), or by allylic chloride, yielding (allyl)(2-menthylindenyl)Mo(CO)₂ (15). All compounds were formed stereomerically pure and were obtained after chromatog. by dried alumina under nitrogen. The structures of 3, 4, 6, 7, and 14 were determined by single-crystal x-ray diffractometry. Variable temperature ¹H NMR spectra of 5, 6, 8, and 9 were recorded to determine the energy barriers for rotation of ethylene along the metal-indenyl and metal-ethylene axes. In the experiment, the researchers used many compounds, for example, Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1COA of Formula: C8H16Cl2Ir2).

Chlorobis(ethylene)iridium(I) dimer (cas: 39722-81-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C8H16Cl2Ir2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enzymatic hydrolytic resolution of (R,S)-α-chlorophenyl acetates in biphasic media was written by Wang, Pei-Yun;Chen, Teh-Liang;Tsai, Shau-Wei. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2007.Recommanded Product: Methyl 2-chloro-2-phenylacetate This article mentions the following:

A thermally stable carboxyl esterase (SNSM-87) from Klebsiella oxytoca is explored as an enantioselective biocatalyst for the hydrolytic resolution of (R,S)-α-chlorophenyl acetates in biphasic media, where the Et ester possessing the highest enantioselectivity (E* = 95) is selected as the best substrate and rationalized from the linear free energy relationships in terms of the logarithms of kinetic constants and enantiomeric ratio varied with the inductive parameter of leaving alc. An expanded Michaelis-Menten mechanism for the rate-limiting acylation step is adopted for the kinetic anal. Two-stage Bronsted slopes of 58.0 and 2.28 for the fast-reacting (R)-esters, as well as only one-stage slope of 4.15 for the slow-reacting (S)-esters, were found and elucidated from the change of rate-limiting step. The replacement of α-chloro substituent to α-Me or α-hydroxy moiety indicates that the α-substituent has profound effects on varying the enzyme activity, enantioselectivity, and optical-preference for SNSM-87 and lipases of pCPL, Lipase MY, NOVO 435 and Lipase PS. In the experiment, the researchers used many compounds, for example, Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6Recommanded Product: Methyl 2-chloro-2-phenylacetate).

Methyl 2-chloro-2-phenylacetate (cas: 7476-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: Methyl 2-chloro-2-phenylacetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Platinum-catalyzed hydrosilylation of allyl aryl ethers: kinetic investigation at moderately high dilution was written by Coqueret, Xavier;Wegner, Gerhard. And the article was included in Organometallics in 1991.Related Products of 12083-92-0 This article mentions the following:

A kinetic investigation of the platinum-catalyzed hydrosilylation of some allyl aryl ethers by dimethylsilyl end groups of a monofunctional model oligomer or of a telechelic poly(dimethylsiloxane) was performed with use of quant. IR spectrophotometry. The reactivity of (allyloxy)benzene (I), examined at low inital concentration of reactants in toluene (ca. 10^-2 equiv·L^-1), with dichloro(dicyclopentadiene)platinum(II) as a precursor of the catalyst was found to be different from the reactivity of the allylic groups of 3,5-(CH₂:CHCH₂O)₂C₆H₃CO₂Me (II). The reaction rate can be expressed by v(I) = k₃[Pt][Si-H]² in the case of reactions with I and by v(II) = k₄[Pt]²[Si-H]² for reactions with II. In addition to the determination of the values of the phenomenol. rate constants deduced from measurements carried out under mild conditions, the obtained results lead to the proposal of some special features for the effective catalytic process. In the experiment, the researchers used many compounds, for example, Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0Related Products of 12083-92-0).

Dichlorodi(cyclopenta-1,3-dien-1-yl)platinate(II) (cas: 12083-92-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 12083-92-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis was written by Richter, Adrian;Narula, Gagandeep;Rudolph, Ines;Seidel, Ruediger W.;Wagner, Christoph;Av-Gay, Yossef;Imming, Peter. And the article was included in ChemMedChem in 2022.Application In Synthesis of 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid This article mentions the following:

8-Nitrobenzothiazinones (BTZs) were a promising class of antimycobacterial agents currently under investigation in clin. trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and was applicable for preparation of a wide variety of BTZ analogs. The synthetic procedure furthermore facilitates the replacement of the sulfur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogs were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay. In the experiment, the researchers used many compounds, for example, 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4Application In Synthesis of 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid).

2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid (cas: 22227-59-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An “on-water” exploration of CuO nanoparticle catalysed synthesis of 2-aminobenzothiazoles was written by Rout, Saroj Kumar;Guin, Srimanta;Nath, Jayashree;Patel, Bhisma K.. And the article was included in Green Chemistry in 2012.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

An “on-water” one-pot process has been engineered for the preparation of 2-aminobenzothiazole from ortho-halo (-F, -Cl, -Br and -I) substituted unsym. thioureas. For ortho -I and -Br substrates the reactions afford 2-aminobenzothiazoles under metal free condition promoted by base. However, the relatively inert ortho -Cl and -F substrates undergo intramol. arylthiolation only in the presence of CuO nanoparticles yielding 2-aminobenzothiazoles. This methodol. provides easy access to aminobenzothiazoles utilizing even the ortho -Cl and -F substrates. The catalyst is recyclable several times without loss of substantial activity. Other remarkable features include the wide range of functional group tolerance, absence of chromatog. purification (for ortho -I and -Br substrates) and providing moderate to excellent yield of the products under mild conditions, thus rendering the methodol. as a highly eco-friendly alternative to the existing methods. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90 was written by Biamonte, Marco A.;Shi, Jiandong;Hong, Kevin;Hurst, David C.;Zhang, Lin;Fan, Junhua;Busch, David J.;Karjian, Patricia L.;Maldonado, Angelica A.;Sensintaffar, John L.;Yang, Yong-Ching;Kamal, Adeela;Lough, Rachel E.;Lundgren, Karen;Burrows, Francis J.;Timony, Gregg A.;Boehm, Marcus F.;Kasibhatla, Srinivas R.. And the article was included in Journal of Medicinal Chemistry in 2006.Quality Control of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:

Orally active Hsp90 inhibitors are of interest as potential chemotherapeutic agents. Recently, fully synthetic 8-benzyladenines and 8-sulfanyladenines such as 4 were disclosed as Hsp90 inhibitors, but these compounds are not water soluble and consequently have unacceptably low oral bioavailabilities. We now report that water-solubility can be achieved by inserting an amino functionality in the N(9) side chain. This results in compounds that are potent, soluble in aqueous media, and orally bioavailable. In an HER-2 degradation assay, the highest potency was achieved with the neopentylamine 42 (HER-2 IC₅₀ = 90 nM). In a murine tumor xenograft model (using the gastric cancer cell line N87), the H₃PO₄ salts of the amines 38, 39, and 42 induced tumor growth inhibition when administered orally at 200 mg/kg/day. The amines 38, 39, and 42 are the first Hsp90 inhibitors shown to inhibit tumor growth upon oral dosage. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Quality Control of 2-(3-Methoxyphenyl)acetyl chloride).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Quality Control of 2-(3-Methoxyphenyl)acetyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial activity of substituted 4-[(1H-benzo[d]imidazol-2-yl)methyl]phenol derivatives was written by Chittimalla, Srinivasulu;Pochampally, Jalapathi;Maroju, Sreedhar;Velupula, Ganapathi;Bhdraiah, Veera;Thumma, Vishnu;Nalla, Umapathi. And the article was included in Heterocyclic Letters in 2022.Related Products of 620-19-9 This article mentions the following:

A new set of N-substituted benzimidazole analogs I [R = PhC(O), 2-MeC₆H₄CH₂, cyclohexanecarbonyl, etc.] was prepared by the reaction of resp. benzimidazoles with different acids, acid chlorides and alkyl halides under appropriate conditions. All the structures of compounds were analyzed by FT-IR, ¹H-NMR and Mass spectral data. The synthesized compounds I were evaluated for their in vitro antibacterial and antifungal activity and also studied their mol. docking. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Related Products of 620-19-9).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 620-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of Fluoroquinolone Derivatives as Potent α-Glucosidase Inhibitors: In-Vitro Inhibitory Screening with In-Silico Docking Studies was written by Shaheen, Aasia;Ashiq, Uzma;Jamal, Rifat Ara;Khan, Khalid Mohammed;Gul, Sana;Yousuf, Sammer;Ali, Syed Tahir. And the article was included in ChemistrySelect in 2021.COA of Formula: C7H5ClF2 This article mentions the following:

This study was based on synthesis, structure elucidation and biol. evaluation of various fluoroquinolone (enoxacin) analogs with electrophilic substitution of aromatic amine moiety of central enoxacin nucleus by benzyl halides. The synthesized derivatives were characterized on the basis of different chem. and phys. measurements and structures were elucidated by various spectroscopic techniques (NMR, EI-MS), including elemental (CHN) and X-ray diffraction anal. Furthermore these compounds were investigated for their potential α-glucosidase inhibition activities and all synthesized analogs of fluoroquinolones were found to exhibit promising inhibition potential of 45.8±0.2 to 74.5±0.2μM in comparison to IC₅₀ value of 425.6±1.3μM for standard inhibitor of α-glucosidase1-deoxynojirimycin. Further, docking of synthetic compounds were carried out by using α-glucosidase I enzyme of Saccharomyces cerevisiaeas a target. The study provided an insight of the mol. interactions of fluoroquinolone derivatives with the enzyme that were in good agreement with the inhibitory activity of synthesized compounds and can be considered as a valuable tool for designing new drugs. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Stereospecific Cross-Coupling of Secondary Organotrifluoroborates: Potassium 1-(Benzyloxy)alkyltrifluoroborates was written by Molander, Gary A.;Wisniewski, Steven R.. And the article was included in Journal of the American Chemical Society in 2012.Application of 18437-66-6 This article mentions the following:

Potassium 1-(alkoxy/acyloxy)alkyltrifluoroborates have been synthesized through a copper-catalyzed diboration of aldehydes and subsequent conversion of the resulting potassium 1-(hydroxy)alkyltrifluoroborates. The palladium-catalyzed Suzuki-Miyaura reaction employing the potassium 1-(benzyloxy)alkyltrifluoroborates with aryl and heteroaryl chlorides provides access to protected secondary alcs. in high yields. The β-hydride elimination pathway is avoided through use of the benzyl protecting group, which is proposed to stabilize the diorganopalladium intermediate by coordination of the arene to the metal center. This cross-coupling is stereospecific with complete retention of stereochem. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Application of 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics