Month: January 2023

Lewis Acid-Catalyzed Asymmetric Selenocyanation of β-Ketoesters with N-Selenocyanatosaccharin was written by Wu, Di;Qiu, Jiashen;Li, Chengqiu;Yuan, Lexia;Yin, Hongquan;Chen, Fu-Xue. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

The first electrophilic asym. selenocyanation has been achieved in the presence of Ni(OTf)₂ and (R,R)-DBFOX/Ph using N-selenocyanatosaccharin as the new selenocyanation reagent. Thus, a series of α-selenocyanato-β-keto esters were synthesized with high yields (up to 99%) and good ee values (up to 92% ee). The readily preparation of the reagent and high enantioselectivity make this methodol. much practical for the synthesis of chiral selenocyanates. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heavy metal and organic dye removal via a hybrid porous hexagonal boron nitride-based magnetic aerogel was written by Krishna Kumar, A. Santhana;Warchol, Jolanta;Matusik, Jakub;Tseng, Wei-Lung;Rajesh, N.;Bajda, Tomasz. And the article was included in npj Clean Water in 2022.SDS of cas: 61-73-4 This article mentions the following:

Numerous adsorbents have been introduced to efficiently remove heavy metals and organic dyes from environmental water samples. However, magnetic a porous network aerogels are rarely developed to capture inorganic and organic pollutants from aqueous We herein fabricated hexagonal boron nitride nanosheets (h-BNNSs)-based on magnetic hybrid aerogels (MHAs) as a lightweight adsorbent for robust uptake of Cr(VI), As(V), methylene blue (MB) and acid orange (AO). The synthetic procedure of poly(ethyleneimine)-modified h-BNNSs (PEI-h-BNNSs) involved thermal poly condensation of melamine and boric acid, pyrolysis of the resultant products which allowed exfoliated by ultra-sonication process further functionalization with PEI-mediated modification of h-BNNSs. The as formed PEI-h-BNNSs allowed in-situ formation of magnetite nanoparticles (Fe₃O₄ NPs) decorated on their surfaces, which are turned to be PEI-h-BNNSs@Fe₃O₄ NPs. The lyophilization treatment of PEI-h-BNNSs@Fe₃O₄ NPs-loaded PVA hydrogels generated the MHAs with large porous structures, diverse and numerous functional groups, good super-paramagnetic and a zero net surface charge. These features enabled the proposed adsorbent (MHAs) to be utilized to efficiently remove Cr(VI), As(V), MB, and AO from an aqueous solution, with maximum adsorption capacity estimated to be 833, 426, 415, 286 mg g^-1, resp. The adsorption kinetics and isotherm data demonstrated that MHAs mediated adsorption of Cr(VI), As(V), MB and AO followed the Freundlich isotherm model and a pseudo-second-order kinetics model. This finding signifies that the MHAs exhibit heterogeneous binding behavior with multilayer chemisorption of Cr(VI), As(V), MB and AO. Subsequently, the practical application were validated by conducting their detoxification of chromium and arsenic in soli-sludge samples. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4SDS of cas: 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4-oxo-2-butenoic acid derivatives: design, synthesis and anti-HIV-1 activity was written by Karimi, Nafiseh;Roudsari, Rouhollah Vahabpour;Movahed, Mahsa Azami;Hajimahdi, Zahra;Zarghi, Afshin. And the article was included in Iranian Journal of Pharmaceutical Research in 2021.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

Integrase, targeted in highly active antiretroviral therapy (HAART), was a crucial enzyme in viral replication. In this study, new benzimidazolyl diketo acid derivatives I [R = Ph, 2-MeC₆H₄, 2-FC₆H₄, etc.] were designed according to required features for inhibitors of HIV-1 integrase. Designed compounds I were evaluated for anti-HIV-1 effects and docking studies indicated that the binding mode of compound I [R = 2-FC₆H₄] was similar to INSTIs. According to the cell-based biol. assay’s results, most of the tested compounds I demonstrated good anti-HIV-1 activity, ranging from 40-90μM concentration with no severe cytotoxicity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 1-Indanones from Benzoic Acids was written by Huang, Yun-Sheng;Liu, Jian-Qiang;Zhang, Lang-Jun;Lu, He-Lin. And the article was included in Industrial & Engineering Chemistry Research in 2012.Safety of 5-Chloro-2-methoxybenzoic acid This article mentions the following:

An improved process for the preparation of 1-indanones, e.g., I, from various benzoic acids is described. This process involves a Friedel-Crafts acylation between a substituted benzoyl chloride and ethylene, followed by an intramol. Friedel-Crafts alkylation in the presence of aluminum chloride. The described process combines three steps into a one-pot process, is scalable, is cost-effective, and thus has a general applicability in manufacturing production of various 1-indanones. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Safety of 5-Chloro-2-methoxybenzoic acid).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 5-Chloro-2-methoxybenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and herbicidal activities of novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives was written by Xu, Han;Hu, Xu Hong;Zhu, You Quan;Zou, Xiao Mao;Liu, Bin;Hu, Fang Zhong;Yang, Hua Zheng. And the article was included in Science China: Chemistry in 2010.Computed Properties of C7H5ClF2 This article mentions the following:

Three series of forty-nine novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives are designed, synthesized, and evaluated through a Spirodela polyrrhiza test and a greenhouse test. Some compounds show > 80% chlorophyll inhibition of Spirodela polyrrhiza at 10 μg/mL and exhibit some herbicidal activities against Digitaria adscendens in the preemergence treatment at a rate of 150 g/ha. Moreover, the study of the structure-activity relationship (SAR) suggests that the appropriate bulky substituent at the right position is critical for the bleaching and herbicidal activities, which may be useful for the future design of new compounds In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Computed Properties of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of fungicide fluquinconazole was written by Wang, Guang-yu;Zhou, Yue-gen;Wang, Hui;Kong, Fan-lei. And the article was included in Nongyao in 2014.COA of Formula: C7H3Cl2NS This article mentions the following:

This article aims to study the synthetic route of fluquinconazole. Fluquinconazole was obtained from 2-amino-5-fluorobenzoic acid through reactions of condensation and ring-closure by one-pot method, chlorination and nucleophilic substitution. Under the optimal reaction conditions, the total yield of fluquinconazole was 67.1% based on 2-amino-5-fluorobenzoic acid, the purity was 99%. The structure was confirmed by HPLC-MS, ¹H NMR. This method can be used as an effective path to synthesize fluquinconazole in industrial scale for the advantages of mild reaction condition and high yield. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1COA of Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, pharmacokinetics, and biological activity of a series of new pyridonecarboxylic acid antibacterial agents bearing a 5-fluoro-2-pyridyl group or a 3-fluoro-4-pyridyl group at N-1 was written by Yoon, Sung June;Chung, Yong Ho;Lee, Chi Woo;Oh, Yoon Seok;Choi, Dong Rack;Kim, Nam Doo;Lim, Jae Kyung;Jin, Yoon Ho;Lee, Dug Keun;Lee, Won Yong. And the article was included in Journal of Heterocyclic Chemistry in 1997.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:

The 1-(5-fluoro-2-pyridyl) or 1-(3-fluoro-4-pyridyl) group was introduced in the syntheses of new pyridonecarboxylic acid antibacterial agents. 1-(5-Fluoro-2-pyridyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxoquinolone-3-carboxylic acid (DW-116) showed a moderate in vitro antibacterial activity, but it was found to have very excellent pharmacokinetic profiles so that DW-116 showed dramatic increased in vivo efficacy. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Broad thermal spectrum metagenomic laccase with action for dye decolorization and fentin hydroxide treatment was written by Lima, Natalia Sarmanho Monteiro;Gomes-Pepe, Elisangela Soares;Campanharo, Joao Carlos;de Macedo Lemos, Eliana Gertrudes. And the article was included in AMB Express in 2022.Computed Properties of C16H18ClN3S This article mentions the following:

Laccases are multicopper oxidases that act on various phenolic and non-phenolic compounds, enabling numerous applications including xenobiotic bioremediation, biofuel production, drug development, and cosmetic production, and they can be used as additives in the textile and food industries. This wide range of uses makes these enzymes extremely attractive for novel biotechnol. applications. Here, we undertook the kinetic characterization of LacMeta, a predicted as homotrimeric (âˆ?107,93 kDa) small laccase, and demonstrated that this enzyme performs best at an acidic pH (pH 3-5) towards ABTS as substrate and has a broad thermal spectrum (10-60 °C), which can promote high plastic action potential through dynamic environmental temperature fluctuations. This enzyme showed following kinetic parameters: k_cat = 6.377 s^-1 ± 0.303, K_m = 4.219 mM, and V_max = 24.43 μM/min (against ABTS as substrate). LacMeta almost completely degraded malachite green (50 mg/mL) in only 2 h. Moreover, the enzyme was able to degrade seven dyes from four distinct classes and it resp. achieved 85% and 83% decolorization of methylene blue and trypan blue with ABTS as the mediator. In addition, LacMeta showed potential for the degradation of two thirds of an agricultural fungicide: fentin hydroxide, thus demonstrating its biotechnol. aptitude for bioremediation. The results of this study suggest that LacMeta has potential in textile wastewater treatment and that it could help in the bioremediation of other human/environmental toxins such as pesticides and antibiotic compounds belonging to the same chem. classes as the degraded dyes. In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Computed Properties of C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Esters of γ-chloro-β-hydroxy- and β,γ-dichlorobutyric acid. Preparation of pure ethyl γ-chlorocrotonate was written by Broche, Andre;Rambaud, Rene. And the article was included in Compt. rend. in 1944.Recommanded Product: (E)-4-Chlorobut-2-enoic acid This article mentions the following:

The action of P₂O₅ on ClCH₂CH (OH) CH₂CO₂Et gives ClCH₂CH:CHCO₂Et (I) contaminated with ClCH:CHCH₂CO₂Et (II), and pure I cannot be obtained by distillation The mixture always shows lines in the ethylenic region of the Raman spectrum at 1666, 1651, and 1607 cm.^-1; the last two are of approx. equal intensity and are weaker than the first. Pure II is obtained by the following series of reactions. The action of SOCl₂ on ClCH₂CH(OH)CH₂CO₂Et gives ClCH₂CHClCH₂CO₂Et, b₁₂ 94-5°, d. 1.217, n_D¹⁹ 1.456; this with dilute NaOH yields trans-ClCH₂CH:CHCO₂H, m. 82.7°, which with SOCl₂ gives ClCH₂CH:CHCOCl, b₁₆ 74-4.5°, d. 1.316, n_D¹¹ 1.501, and this with C₅H₅N and EtOH yields I, b₁₃ 83°, d. 1.118, n_D¹⁴ 1.463. The Raman spectrum of pure I shows lines at only 1666 and 1651 cm.^-1; it is therefore trans, by analogy with the Me and Et fumarates, which show 2 unequal lines. The following esters were prepared From ClCH₂CH(OH)CH₂CO₂H: Me, b₁₃ 104-5°, d. 1.259, n_D^14.5 1.458; Pr, b₈ 114-15°, d. 1.150, n_D²¹ 1.453; Bu, b₄ 123-4.5°, d. 1.121, n_D²⁰ 1.453; iso-Bu, b₉ 122-4°, d. 1.116, n_D²⁴ 1.451. From ClCH₂CHClCH₂CO₂H: Me, b₁₅ 89.5-90°, d. 1.278, n_D²³ 1.459; Pr, b₁₄ 114-15°, d. 1.175, n_D¹⁹ 1.454; Bu, b₁₅ 127-8°, d. 1.143, n_D²⁴ 1.454; iso-Bu, b₁₅ 121-2°, d. 1.138, n_D²⁰ 1.452. In the experiment, the researchers used many compounds, for example, (E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9Recommanded Product: (E)-4-Chlorobut-2-enoic acid).

(E)-4-Chlorobut-2-enoic acid (cas: 26340-58-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: (E)-4-Chlorobut-2-enoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Flavor characteristics of shrimp sauces with different fermentation and storage time was written by Zhu, Wenhui;Luan, Hongwei;Bu, Ying;Li, Xuepeng;Li, Jianrong;Ji, Guangren. And the article was included in LWT–Food Science and Technology in 2019.COA of Formula: C18H37Cl This article mentions the following:

The present study investigated the volatile compounds in nearly three-year shrimp sauces and the effects of different fermentation and storage time on the integral aroma characteristics. The 89 volatile compounds were identified by solid phase microextraction (SPME) and gas chromatog.-mass spectrometry (GC-MS) anal. Compared with the other two samples, the shrimp sauces which fermented and storage for 2 years has the highest umami amino acid content and the better flavor. The results of electronic nose (e-nose) and electronic tongue (e-tongue) detection to distinguish the aroma characteristics of different samples demonstrated good agreement with those obtained by GC-MS anal. These results suggested that proper fermentation and storage time are critical to the flavor quality of shrimp sauces. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.COA of Formula: C18H37Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics