Month: January 2023

Electrochemical degradation of methylene blue accompanied with the reduction of CO₂ by using carbon nanotubes grown on carbon fiber electrodes was written by Luan, Nhat Huy;Yang, Yu-Ting;Chang, Chiung-Fen. And the article was included in Sustainable Environment Research in 2022.Product Details of 61-73-4 This article mentions the following:

In this study, the degradation of Methylene Blue (MB) dye accompanied with the reduction of CO₂ was performed in an electrochem. (EC) process by using carbon nanotubes grown on carbon fiber (CNTs/CFM) electrodes as the cathode and anode in a two-compartment electrochem. cell. The growth of CNTs on CFM via chem. vapor deposition led to the significant improvement in physicochem. properties of CNTs/CFM which were beneficial for the EC process. The effects of various operating parameters including supporting electrolytes (KHCO₃ and H₂SO₄), initial concentration of MB (5, 10, 15 and 20 mg L^-1) and applied currents (10, 50 and 100 mA) on the degradation of MB were investigated. The results confirmed the vital influence of applied current and initial concentration of MB while the supporting electrolytes played a minor role in MB degradation On the contrary, the influence of electrolytes in the performance of CO₂ reduction was more significant on the production and selectivity of generated products. The optimal electrochem. system included 0.1 M KHCO₃ as the electrolyte and an applied current of 50 mA in anodic cell and CO₂ saturated solution in cathodic cell; such a system resulted in the EC degradation efficiency of 72% at the MB initial concentration of 10 mg L^-1 in the anodic cell and production of 4.7 mM cm^-2 CO, 67 mM cm^-2 H₂, and 11.3 mg L^-1 oxalic acid in the cathodic cell corresponding to the Faradaic efficiencies of 28, 40 and 4%, resp. The results of reusability test deduced that the stability of CNTs/CFM was still satisfactory after 4 runs. The results of this study demonstrated the good applicability of CNTs/CFM to be simultaneously used the electrodes for the EC oxidation of dye and the EC reduction of CO₂ to obtain valuable compounds In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Product Details of 61-73-4).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 61-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Experimental and Computational Exploration of para-Selective Silylation with a Hydrogen-Bonded Template was written by Maji, Arun;Guin, Srimanta;Feng, Sheng;Dahiya, Amit;Singh, Vikas Kumar;Liu, Peng;Maiti, Debabrata. And the article was included in Angewandte Chemie, International Edition in 2017.SDS of cas: 697-73-4 This article mentions the following:

The regioselective conversion of C-H bonds into C-Si bonds is extremely important owing to the natural abundance and non-toxicity of silicon. Classical silylation reactions often suffer from poor functional group compatibility, low atom economy, and insufficient regioselectivity. Herein, we disclose a template-assisted method for the regioselective para silylation of toluene derivatives A new template was designed, and the origin of selectivity was analyzed exptl. and computationally. An interesting substrate-solvent hydrogen-bonding interaction was observed Kinetic, spectroscopic, and computational studies shed light on the reaction mechanism. The synthetic significance of this strategy was highlighted by the generation of a precursor of a potential lipophilic bioisostere of γ-aminobutyric acid (GABA), various late-stage diversifications, and by mimicking enzymic transformations. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Anisotropic Ferromagnetic Organic Nanoflowers was written by Sasidharan, Sajitha;Ghosh, Sayandeep;Sreedhar, Rishi;Kumari, Kalpana;Thota, Subhash;Ramakrishnan, Vibin. And the article was included in Journal of Physical Chemistry C in 2022.Application In Synthesis of (Chloromethanetriyl)tribenzene This article mentions the following:

We report a weak anisotropic ferromagnetic behavior in a purely organic mol. at room temperature, a property rarely reported in organic nanomaterials. The reported 1,2-bis(tritylthio)ethane, forming plate- and organic-flower-like morphologies at the nanolevel, is the first organic crystal with an inherent magnetic property at 300 and 2 K. However, at low temperatures, the magnetization value [M_max(T) ~116 emu/mol at 2 K] increases drastically at 3 orders higher compared to 300 K. Interestingly, the system exhibits strong anisotropy with an anisotropic constant, K₁ ~3.25 x 10³ erg/cc, and anisotropy field, H_K ~3.25 kOe. Below 10 K, this system displays unusual temperature dependence of the coercive field [H_C(T)] and remanence magnetization [M_R(T)] with a hysteresis-peak anomaly (T* ~10-15 K) due to the enhanced spin-orbit coupling. The maximum H_C and M_R at T* were H_C = 220 Oe and M_R ~12 emu/mol, resp. Beyond T*, H_C(T) and M_R(T) drop continuously and become negligible as the measurement temperature approaches 300 K. Our results demonstrate that the tri-Ph mols. can be further exploited for the design and synthesis of organic magnets for possible applications in spintronics and memory storage devices. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Application In Synthesis of (Chloromethanetriyl)tribenzene).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of (Chloromethanetriyl)tribenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved was written by Wang, Guangqiang;Zhang, Hongna;Zhang, Jianan;Sanidad, Katherine Z.;Yeliseyev, Vladimir;Parsonnet, Julie;Haggerty, Thomas D.;Yang, Haixia;Ai, Lianzhong;Xie, Minhao;Cai, Zongwei;Zhang, Guodong. And the article was included in Science of the Total Environment in 2021.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea This article mentions the following:

Metabolic transformations play critical roles in the bioavailability and toxicities of environmental pollutants and toxicants. However, most previous research has focused on the metabolic reactions in host tissues, the gut microbiota-mediated biotransformation of environmental compounds is understudied. Using triclocarban (TCC) as a model environmental compound, here we study the metabolic fate of TCC in gut tissues and determine the roles of gut microbiota involved. We find that compared with other tissues, the colon tissue has a unique metabolic profile of TCC, with high abundance of the parent compound TCC and its free-form metabolites. Using a variety of approaches including antibiotic-mediated suppression of gut bacteria in vivo, germ-free mice, and in vitro culture of fecal bacteria, we found that the unique metabolic profile of TCC in the colon is mediated by the actions of gut microbiota. Overall, our findings support that gut microbiota plays important roles in colonic metabolism of TCC, highlighting the importance to consider the contributions of gut microbiota in toxicol. evaluation of environmental compounds In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea).

1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of 7,9-Disulfatetrahydroberberine as Novel Lipid-Lowering Agents was written by Li, Dong-Dong;Yu, Pan;Wang, Zhen-Zhong;Xiao, Wei;Zhou, Xin-Hu;Zhao, Lin-Guo. And the article was included in ACS Omega in 2020.Electric Literature of C7H4ClF3O2S This article mentions the following:

Berberine (BBR), a well-known alkaloid, exhibits various pharmacol. activities, especially hypolipidemic activity, which has attracted much interest from medicinal chemists in the past decade. However, little progress was made on the structural modification of BBR for improving lipid-lowering activity, mainly due to its unclear biol. target and low safety. In this study, a new scaffold of 7,9-disulfatetrahydroberberine was discovered unexpectedly, provided with extremely low cytotoxicity. Hence, a novel series of highly safe 7,9-disulfatetrahydroberberines were designed, synthesized, and evaluated for their hypolipidemic activities. In order to investigate the significance of the 9-position substituent, another new series of 7-sulfatetrahydroberberines were designed and synthesized. Lipid-lowering experiments showed that among these compounds, 5f exhibited the best lipid-lowering activity based on two cell models, 3T3-L1 cells and HepG2 cells. Compared with the blank control, the inhibition rate of compound 5f against total cholesterol was over 60%, the inhibition rate against triglyceride was over 70%, the inhibition rate against low-d. lipoprotein cholesterol was approx. 75%, and the inhibition rate against high-d. lipoprotein cholesterol was close to 50%, which were far superior to the pos. control BBR. This result also verified the feasibility of the development of BBR as a lipid-lowering drug via disubstituted modification at the 7- and 9-position. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Electric Literature of C7H4ClF3O2S).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C7H4ClF3O2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Covalently Immobilizable Tris(Pyridino)-Crown Ether for Separation of Amines Based on Their Degree of Substitution was written by Vezse, Panna;Benda, Bianka;Fekete, Andras;Golcs, Adam;Toth, Tunde;Huszthy, Peter. And the article was included in Molecules in 2022.Synthetic Route of C19H15Cl This article mentions the following:

A great number of biol. active compounds contain at least one amine function. Appropriate selectivity can only be accomplished in a few cases upon the substitution of these groups, thus functionalization of amines generally results in a mixture of them. The separation of these derivatives with very similar characteristics can only be performed on a preparative scale or by applying pre-optimized HPLC methods. A tris(pyridino)-crown ether was designed and synthesized for overcoming these limitations at a mol. level. It is demonstrated, that this selector mol. is able to distinguish protonated primary, secondary and tertiary amines by the formation of reversible complexes with different stabilities. This degree of substitution-specific mol. recognition of amines opens the door to develop separation processes primarily focusing on the purification of biol. active compounds in a nanomolar scale. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Synthetic Route of C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease was written by Swarbrick, Crystall;Zogali, Vasiliki;Chan, Kitti Wing Ki;Kiousis, Dimitrios;Gwee, Chin Piaw;Wang, Sai;Lescar, Julien;Luo, Dahai;von Itzstein, Mark;Matsoukas, Minos-Timotheos;Panagiotakopoulos, George;Vasudevan, Subhash G.;Rassias, Gerasimos. And the article was included in European Journal of Medicinal Chemistry in 2021.Recommanded Product: 63624-28-2 This article mentions the following:

The flavivirus genus of the Flaviviridae family comprises Dengue, Zika and West-Nile viruses which constitute unmet medical needs as neither appropriate antivirals nor safe vaccines are available. The dengue NS2BNS3 protease is one of the most promising validated targets for developing a dengue treatment however reported protease inhibitors suffer from toxicity and cellular inefficacy. Here we report SAR on our previously reported Zika-active carbazole scaffold, culminating in prodrug compound SP-471P (EC₅₀ 1.10μM, CC₅₀ > 100μM) that generates SP-471 (I â†?II); one of the most potent, non-cytotoxic and cell-active protease inhibitors described in the dengue literature. In cell-based assays, SP-471P leads to inhibition of viral RNA replication and complete abolishment of infective viral particle production even when administered 6 h post-infection. Mechanistically, SP-471 appears to inhibit both normal intermol. protease processes and intramol. cleavage events at the NS2BNS3 junction, as well as at NS3 internal sites, all critical for virus replication. These render SP-471 a unique to date multimodal inhibitor of the dengue protease. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Recommanded Product: 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-/Silver-Mediated Arylation of C(sp²)-H Bonds with 2-Thiophenecarboxylic Acids was written by Zhao, Sheng;Liu, Yue-Jin;Yan, Sheng-Yi;Chen, Fa-Jie;Zhang, Zhuo-Zhuo;Shi, Bing-Feng. And the article was included in Organic Letters in 2015.Category: chlorides-buliding-blocks This article mentions the following:

A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. E.g., in presence of CuOAc, AgNO₃, and Li₂CO₃ in DMF, arylation of I with 2-thiophenecarboxylic acid gave 67% 2-fluoro-N-(2-(pyridin-2-yl)propan-2-yl)-2-(thiophen-2-yl)benzamide (II). The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2Category: chlorides-buliding-blocks).

2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient 4,5-dihydro-1H-imidazol-5-one formation from amidines and ketones under transition-metal free conditions was written by Xie, Yanjun;Cheng, Xiufang;Liu, Saiwen;Chen, Hui;Zhou, Wang;Yang, Luo;Deng, Guo-Jun. And the article was included in Green Chemistry in 2015.Related Products of 18637-02-0 This article mentions the following:

An efficient procedure for 4,5-dihydro-1H-imidazol-5-one preparation from aryl amidines and ketones under transition-metal free conditions is described. When cyclic ketones were employed, various spiro-fused 4,5-dihydro-1H-imidazol-5-ones were formed in high yields via rearrangement reaction. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Related Products of 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organometallic Silver(I) Supramolecular Complexes Generated from Multidentate Furan-Containing Symmetric and Unsymmetric Fulvene Ligands and Silver(I) Salts was written by Dong, Yu-Bin;Geng, Yan;Ma, Jian-Ping;Huang, Ru-Qi. And the article was included in Inorganic Chemistry in 2005.Category: chlorides-buliding-blocks This article mentions the following:

One new conjugated sym. fulvene ligand L1 (I, R = 2-furyl) and two new unsym. fulvene ligands L2 and L3 (I, R = 4- and 3-cyanophenyl, resp.) were synthesized. Five new supramol. complexes, Ag₂(L1)₃(SO₃CF₃)₃ (1, monoclinic, space group P2₁/c; a 12.702(3), b 26.118(7), c 13.998(4) Å, β 96.063(4)°, Z = 4), [Ag(L1)]ClO₄ (2, monoclinic, space group C2/c; a 17.363(2), b 13.2794(18), c 13.4884(18) Å, β 100.292(2)°, Z = 8), [Ag(L1)(C₆H₆)SbF₆]·0.5C₆H₆·H₂O (3, monoclinic, P2₁/c; a 6.8839(11), b 20.242(3), c 18.934(3) Å, β 91.994(3)°, Z = 4), Ag(L2)(SO₃CF₃) (4, triclinic, P1̅; a 8.629(3), b 10.915(3), c 11.178(3) Å, α 100.978(4), β 91.994(3), γ 105.652(4)°, Z = 2), and Ag(L3)(H₂O)(SO₃CF₃) (5, triclinic, P1̅; a 8.914(5), b 10.809(6), c 11.283(6) Å, α 69.255(8), β 87.163(9), γ 84.993(8)°, Z = 2) were obtained through self-assembly based on these three new fulvene ligands in a benzene/toluene mixed-solvent system. Compounds 1–5 were fully characterized by IR spectroscopy, elemental anal., and single-crystal x-ray diffraction. The coordination chem. of new fulvene ligands is versatile. They can adopt either cis- or trans-conformation to bind soft acid Ag(I) ion through not only the terminal -CN and furan functional groups but also the fulvene carbon atoms into organometallic coordination polymers or discrete complexes. The luminescent properties of L1-L3 and their Ag(I) complexes were studied preliminarily in EtOH and solid state. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Category: chlorides-buliding-blocks).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics