Month: January 2023

N-[(Trifluoromethyl)thio]saccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent was written by Xu, Chunfa;Ma, Bingqing;Shen, Qilong. And the article was included in Angewandte Chemie, International Edition in 2014.Recommanded Product: 14070-51-0 This article mentions the following:

A new, electrophilic trifluoromethylthiolaton agent N-[(trifluoromethyl)thio]saccharin, was developed and can be synthesized in two steps from saccharin within 30 min. N-[(trifluoromethyl)thio]saccharin is a powerful trifluoromethylthiolation agent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcs., amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-keto esters, and alkynes under mild reaction conditions. The synthesis of the target compounds was achieved using 2-[(trifluoromethyl)thio]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide as a key reactant. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Recommanded Product: 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed meta-Selective C-H Alkenylation and Acetoxylation of Arylacetic Acid Using a Pyrimidine Template was written by Jiao, Bo;Peng, Zhen;Dai, Zhen-Hua;Li, Lei;Wang, He;Zhou, Ming-Dong. And the article was included in European Journal of Organic Chemistry in 2019.Application of 6834-42-0 This article mentions the following:

In the presence of Pd(OAc)₂ and N-acetylglycine, pyrimidinylphenyl esters of arylacetic acids such as I underwent regioselective meta-selective alkenylation reactions with electron-deficient alkenes such as Et acrylate mediated by Ag₂CO₃ in hexafluoroisopropanol to yield alkenylarylacetate esters such as II. Using PhI(OAc)₂ as oxidant and Ac₂O, four of the pyrimidinylphenyl esters underwent regioselective acetoxylation to yield acetoxyphenylacetates. The pyrimidinylphenyl moiety was readily removable from the products and recovered. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Application of 6834-42-0).

2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 6834-42-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemometrical analysis of substituent effects. IV. Additivity of substituent effects in dissociation of 3,5-disubstituted benzoic acids in organic solvents was written by Pytela, Oldrich;Kulhanek, Jiri;Ludwig, Miroslav. And the article was included in Collection of Czechoslovak Chemical Communications in 1994.Recommanded Product: 56961-33-2 This article mentions the following:

Ten 3,5-disubstituted benzoic acids have been synthesized containing all possible combinations of the following substituents: CH₃O, CH₃, Cl/Br, NO₂. The dissociation constants of these acids have been measured in seven organic solvents (methanol, acetone, DMSO, DMF, acetonitrile, pyridine, 1,2-dichloroethane). It has been found that the effect of disubstitution is smaller than that due to interaction of substituents or their solvation and represents only about 0.2% of the effect caused by the individual substituents. The additivity in 3,5-disubstitution is about 2-3 times as good as that in 3,4-disubstitution. The quant. description of substituent effects at the 3 and 5 positions is additive within the range of validity of the Hammett equation irresp. of the type of the substituent constants adopted, the addition of the multiplicative term being statistically insignificant. The solvent effect on 3,4- and 3,5-disubstituted derivatives is somewhat different at the same value of the reaction constant, due predominantly to the specific solvation of the 4-CH₃O and 4-NO₂ groups. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-methylbenzoic acid (cas: 56961-33-2Recommanded Product: 56961-33-2).

3-Chloro-5-methylbenzoic acid (cas: 56961-33-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 56961-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanism of oxidation of (p-substituted phenylthio)acetic acids with N-chlorosaccharin was written by Alhaji, N. M. I.;Uduman Mohideen, A. M.;Lawrence Mary, S. Sofia. And the article was included in E-Journal of Chemistry in 2011.Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

The kinetics of oxidation of (phenylthio)acetic acid (PTAA) with N-chlorosaccharin (NCSA) have been studied potentiometrically in 80:20 (volume/volume) acetonitrile-water medium at 298 K. The reaction is first-order each with respect to PTAA and NCSA and shows a neg. dependence on [H⁺]. NCSA itself is shown to be the active oxidizing species. Effects of ionic strength variation, added saccharin, added acrylonitrile, added NaCl and solvent composition variation have been studied. Effect of substituents on the reaction rate has been analyzed by employing various (p-sustituted phenylthio)acetic acids. The electron-releasing substituent in the Ph ring of PTAA accelerates the reaction rate while the electron-withdrawing substituent retards the rate. The excellently linear Hammett plot yields a large neg. ρ value, supporting the involvement a chlorosulfonium ion intermediate in the rate-determining step. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient and Scalable Synthesis of Ethyl 2,6-Dichloro-5-Fluoronicotinoyl Acetate Using the Blaise Reaction as a Key Step was written by Choi, Bo Seung;Chang, Jay Hyok;Choi, Hyeong-wook;Kim, Young Keun;Lee, Ki Kon;Lee, Kyu Woong;Lee, Jae Hoon;Heo, Taeho;Nam, Do Hyun;Shin, Hyunik. And the article was included in Organic Process Research & Development in 2005.Category: chlorides-buliding-blocks This article mentions the following:

An efficient synthesis of 2,6-dichloro-5-fluoronicotinoyl acetate (I) has been accomplished in a single step using the Blaise reaction of Et bromoacetate with 3-cyano-2,6-dichloro-5-fluoropyridine. Use of methanesulfonic acid as an in situ activator of zinc removed the induction period of the Blaise reaction to render it safe and viable for a large-scale operation. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Category: chlorides-buliding-blocks).

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzoic esters and electronic affinities of radicals. III was written by Zaki, Ahmad. And the article was included in Journal of the Chemical Society in 1932.Application In Synthesis of Chloromethyl benzoate This article mentions the following:

The glycol dibenzoates supply evidence for the order Cl > O > H with regard to m-nitration induced by substitution in a saturated chain; the following percentages of m-NO₂ compound were obtained for n = 1, 2 and 3: BzO(CH₂)_n-OBz 80.8, 74.8, 75.8; BzO(CH₂)_nH 72.6, 69.6, 71.8; BzO(CH₂)_nCl 81.9, 75.8, 77.7. Nitration of cyclohexyl benzoates gave the following percentages of m-NO₂ compound: cyclohexyl 67; 2-Me derivative 65.4; 3-Me derivative 67.2; 4-Me derivative 67.3; these figures confirm the hypothesis that the repulsion of electrons is increased by increasing C substitution. Since the values are appreciably higher than those for hexyl benzoate (63.7%), this can only be due to the closure of the ring; ring closure alone, however, which produced but a small effect (3%), can be responsible for only a small fraction of the difference (20%) observed in the benzylamine bases. The percentages of m-nitration of the 3 nitrobenzyl benzoates were: o-76, m- 73, p- 75; these show that all the O₂NC₆H₄CH₂ radicals are less directive than Me. Benzodiethylamide gives an average of 29.5% m-nitration; benzoylpiperidine 31%; benzamide 69%. m-Nitration is therefore considerably lowered by the substitution of the H atoms of the NH₂ group. Aryl benzoates are also discussed. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application In Synthesis of Chloromethyl benzoate).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of Chloromethyl benzoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic reductive desymmetrization of malonic esters was written by Xu, Pengwei;Huang, Zhongxing. And the article was included in Nature Chemistry in 2021.Application of 5335-05-7 This article mentions the following:

Here, a dinuclear zinc complex with a tetradentate ligand could selectively hydrosilylate one of the carbonyls of malonic esters to give α-quaternary β-hydroxyesters I [R¹ = Me, CH₂F, allyl, etc.; R² = Ph, 3-thienyl, 1-naphthyl, etc.] was reported, providing a promising alternative to the desym. hydrolysis using carboxylesterases. The asym. reduction features excellent enantiocontrol that could differentiate sterically similar substituents and high chemoselectivity toward the diester motif of substrates. Together with the versatile preparation of malonic ester substrates and post-reduction derivatization, the desym. reduction had enabled the synthesis of a diverse array of quaternary stereocenters with distinct structural features. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Application of 5335-05-7).

Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 5335-05-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rhodium-Catalyzed Electrooxidative C-H Olefination of Benzamides was written by Zhang, Yan;Struwe, Julia;Ackermann, Lutz. And the article was included in Angewandte Chemie, International Edition in 2020.Reference of 1711-11-1 This article mentions the following:

Metal-catalyzed chelation-assisted C-H olefinations have emerged as powerful tools for the construction of functionalized alkenes. Herein, the authors describe the rhoda-electrocatalyzed C-H activation/alkenylation of arenes. The olefinations of challenging electron-poor benzamides were thus accomplished in a fully dehydrogenative fashion under electrochem. conditions, avoiding stoichiometric chem. oxidants, and with H₂ as the only byproduct. This versatile alkenylation reaction also features broad substrate scope and used electricity as a green oxidant. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Quadruple Functionalized Pyrazole Pharmacophores by One-pot Regioselective [3+2] Cycloaddition of Fluorinated Nitrile Imines and Dicyanoalkenes was written by Zhou, Yin;Gao, Cheng-Feng;Ma, Hai;Nie, Jing;Ma, Jun-An;Zhang, Fa-Guang. And the article was included in Chemistry – An Asian Journal in 2022.Formula: C8H4ClNO This article mentions the following:

A quadruple functionalization approach for the modular construction of fully substituted N1-aryl 3-di/trifluoro-methyl-4/5-cyanopyrazole pharmacophores from readily available hydrazonyl chlorides and dicyanoalkenes was presented. The realization of this [3+2] cycloaddition reaction hinges upon the employment of N-aryl di/trifluoromethyl nitrile imines as the 1,3-dipoles to bypass external synthetic steps and dicyanoalkenes as the dipolarophiles to tune the regioselectivity. This one-pot strategy offered access to a divergent library of cyano analogs of prevalent 3-di/trifluoromethyl pyrazole pharmacophores, among which several compounds have shown potent inhibitory activity towards cyclooxygenase 2 (COX-2) compared with marketed drug Celecoxib. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization, and antioxidant activity of some new N⁴-arylsubstituted-5-methoxyisatin-β-thiosemicarbazone derivatives was written by Muglu, Halit. And the article was included in Research on Chemical Intermediates in 2020.Recommanded Product: 6590-96-1 This article mentions the following:

Firstly, thiosemicarbazides were prepared by the reaction of hydrazine monohydrate with isothiocyanates in cold dry ethanol at 0° for 1 h. After that, new isatin-β-thiosemicarbazones I (R = 2-MeC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, etc.) were synthesized by treatment of 5-methoxyisatin with thiosemicarbazides in aqueous ethanol containing one drop of hydrochloric acid at reflux for 3 h. All the synthesized compounds were evaluated for their antioxidant activity by 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging method. The synthesized mols. showed lower antioxidant activity than the standard trolox (8.757μM). IC₅₀ values of the newly synthesized isatin-β-thiosemicarbazone derivatives ranged from 12.455 to 73.471μM. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics