Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds was written by Zhou, Ya;Beeler, Aaron B.;Cho, Sanghyun;Wang, Yuehong;Franzblau, Scott G.;Snyder, John K.. And the article was included in Journal of Combinatorial Chemistry in 2008.Category: chlorides-buliding-blocks This article mentions the following:
The chem. of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds I [R = H, R1 = Me, R2 = Ph, CH2OPh, n-Bu; R1 = Ph, R2 = 2-Me-4-MeOC6H3], synthesized by intramol. cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compds I [R = (R)-PhCH(Me)NHCO, 4-MeOC6H4NHCO, 4-NCC6H4SO2, R1 = Ph, R2 = 2-Me-4-MeOC6H3]. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Category: chlorides-buliding-blocks).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics