Synthesis and biological screening of some new 5,7-dihydro-4H-thieno[2,3-c]pyran-3-yl containing 1,2,4-triazoles, 1,3,4-oxadiazoles, and 1,3-thiazoles was written by Jadhav, Ranjana K.;Akolkar, Hemant N.;Nikumbh, Arun B.;Karale, Bhausaheb K.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2021.Computed Properties of C7H3Cl2NS This article mentions the following:
Some new 5,7-dihydro-4H-thieno[2,3-c]pyran thiosemicarbazides I [R1 = H, Cl, OMe, OCF3, Me, Et, R3 = Cl, H, F] were synthesized from 5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbohydrazide and aryl isothiocyanates in ethanol. Compounds I, on refluxing with 1N NaOH, gave (thieno[2,3-c]pyranyl)(phenyl)-4H-1,2,4-triazole-3-thiols II, and with 4N NaOH in the presence of I2/KI gave (thieno[2,3-c]pyranyl)-N-phenyl-1,3,4-oxadiazol-2-amines III. When I were reacted with 2-bromo-1-(4-fluorophenyl)ethanone to obtain (11Z)-(thiazol-2(3H)-ylidene)-4H-thieno[2,3-c]pyran-3-carbohydrazides IV. The structures of the synthesized compounds were confirmed by using spectral techniques. The compounds were also screened for their antifungal and antibacterial activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics