Synthesis and urease inhibitory activities of benzophenone semicarbazones/thiosemicarbazones was written by Arshia, Arshia;Khan, Ajmal;Khan, Khalid Mohammed;Saad, Syed Muhammad;Siddiqui, Nida Iqbal;Javaid, Sumaira;Perveen, Shahnaz;Choudhary, M. Iqbal. And the article was included in Medicinal Chemistry Research in 2016.Name: 2,4-Dichlorophenylisothiocyanate This article mentions the following:
Twenty-five benzophenone semicarbazones and thiosemicarbazones were synthesized starting from benzophenones via hydrazones treated with different aryl isocyanates and isothiocyantes under reflux. All synthetic derivatives were evaluated for their urease inhibitory potential. A good-to-moderate inhibition trend against urease was observed with IC50 values in the range of 8.7-119.5 μM, when compared with the standard thiourea (IC50 = 21.2 ± 1.3 μM). One compound showed better inhibition than the standard having an IC50 value of 8.7 ± 0.6 μM. Nine compounds with IC50 values within the range of 26.1-43.6 μM, demonstrated good-to-moderate activities while one compound (IC50 = 119.5 ± 1.6 μM) displayed very weak activity. The enzyme kinetic studies on the 2 most active compounds were performed to deduce their modes of inhibition and Ki values. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Name: 2,4-Dichlorophenylisothiocyanate).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2,4-Dichlorophenylisothiocyanate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics