Synthesis and biological evaluation of calycanthaceous alkaloid analogs was written by Zheng, Shaojun;Zhu, Rui;Zhou, Xinping;Chen, Lizhuang;Bai, Hongjin;Zhang, Jiwen. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
Starting from 9-methyl-1,2,3,4,9,9a-hexahydro-4aH-pyrido[2,3-b]indol-4a-ol, or indole-3-acetonitrile, 40 new calycanthaceous alkaloid analogs were synthesized in excellent yields. The prepared compounds were evaluated for biol. activity against acetylcholinesterase and a broad range of plant pathogen fungi. The results of bioassays indicated that the majority of tested compounds displayed comparable or better in vitro bioactivity than the pos. control. Notably, compounds I and II showed higher activity against Verticillium dahlia than chlorothalonil, with MIC values of 62.5 and 7.81μg mL-1, resp. Compound III had a higher activity against Bacillus cereus, with a MIC value of 15.63μg mL-1. Compounds IV and V revealed potent activity against acetylcholinesterase, with MIC values of 0.01 and 0.1 ng mL-1, resp. Anal. of the mol. docking modes of IV and V with Torpedo californica acetylcholinesterase indicated a medium strong hydrogen bond interaction between the hydroxyl groups of both the ligands and the phenolic hydroxyl of Try121 at a distance of approx. 2.4 Å. The results obtained in this study will be useful for the further design and structural optimization of calycanthaceous alkaloids as potential agrochem. lead compounds for plant disease control. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics