Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules was written by You, Weijie;Rotili, Dante;Li, Tie-Mei;Kambach, Christian;Meleshin, Marat;Schutkowski, Mike;Chua, Katrin F.;Mai, Antonello;Steegborn, Clemens. And the article was included in Angewandte Chemie, International Edition in 2017.Formula: C7H4ClF3O2S This article mentions the following:
Sirtuins are protein deacylases regulating metabolism and stress responses, and are implicated in aging-related diseases. Small mol. activators for the human sirtuins Sirt1-7 are sought as chem. tools and potential therapeutics, such as for cancer. Activators are available for Sirt1 and exploit its unique N-terminus, whereas drug-like activators for Sirt2-7 are lacking. The authors synthesized and screened pyrrolo[1,2-a]quinoxaline derivatives, yielding the first synthetic Sirt6 activators. Biochem. assays show direct, substrate-independent compound binding to the Sirt6 catalytic core and potent activation of Sirt6-dependent deacetylation of peptide substrates and complete nucleosomes. Crystal structures of Sirt6/activator complexes reveal that the compounds bind to a Sirt6-specific acyl channel pocket and identify key interactions. The authors’ results establish potent Sirt6 activation with small mols. and provide a structural basis for further development of Sirt6 activators as tools and therapeutics. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Formula: C7H4ClF3O2S).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C7H4ClF3O2S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics