Synthesis, pharmacokinetics, and biological activity of a series of new pyridonecarboxylic acid antibacterial agents bearing a 5-fluoro-2-pyridyl group or a 3-fluoro-4-pyridyl group at N-1 was written by Yoon, Sung June;Chung, Yong Ho;Lee, Chi Woo;Oh, Yoon Seok;Choi, Dong Rack;Kim, Nam Doo;Lim, Jae Kyung;Jin, Yoon Ho;Lee, Dug Keun;Lee, Won Yong. And the article was included in Journal of Heterocyclic Chemistry in 1997.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate This article mentions the following:
The 1-(5-fluoro-2-pyridyl) or 1-(3-fluoro-4-pyridyl) group was introduced in the syntheses of new pyridonecarboxylic acid antibacterial agents. 1-(5-Fluoro-2-pyridyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxoquinolone-3-carboxylic acid (DW-116) showed a moderate in vitro antibacterial activity, but it was found to have very excellent pharmacokinetic profiles so that DW-116 showed dramatic increased in vivo efficacy. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics