Design, synthesis and biological activities of sorafenib derivatives as antitumor agents was written by Yao, Jianwen;He, Zuopeng;Chen, Jing;Sun, Wei;Fang, Hao;Xu, Wenfang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Name: 2,4-Dichlorophenylisothiocyanate This article mentions the following:
A series of novel sorafenib derivatives was designed and synthesized in high yields using various substituted anilines, and their antiproliferative activities against HCT116, PC-3 and MDA-MB-231 cell lines were also evaluated and described. All compounds exhibited potent antiproliferative activity against HCT116 and PC-3 cells with IC50 = 2.8-52.0 and 2.2-45.6 μM; compounds I [R = Et, cyclopropyl] demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines; the cytotoxicity of compound I [R = cyclohexyl] is more potent than that of sorafenib. Some compounds were chosen for further evaluation of the anti-angiogenesis activity, and showed the inhibition of sprout formation from aortic ring ex vivo. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Name: 2,4-Dichlorophenylisothiocyanate).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 2,4-Dichlorophenylisothiocyanate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics