A General Synthesis of N-Hydroxyindoles was written by Wong, Audrey;Kuethe, Jeffrey T.;Davies, Ian W.. And the article was included in Journal of Organic Chemistry in 2003.Recommanded Product: 16588-16-2 This article mentions the following:
A general method for the formation of N-hydroxyindoles is demonstrated through a Pb-promoted intramol. reductive cyclization of o-nitrobenzyl ketones and aldehydes under transfer hydrogenation conditions. The N-hydroxyindoles are isolated in high purity and excellent yield (>90%) in an operationally simple procedure. This new method is exemplified by a two-step synthesis of the naturally occurring 1-methoxyindole-3-carboxaldehyde, which is pivotal in many alkaloid total syntheses. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: 16588-16-2).
Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 16588-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics