Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists was written by Wendt, John A.;Deeter, Susan D.;Bove, Susan E.;Knauer, Christopher S.;Brooker, Rachel M.;Augelli-Szafran, Corinne E.;Schwarz, Roy D.;Kinsora, Jack J.;Kilgore, Kenneth S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application In Synthesis of 3-Cyanobenzoyl chloride This article mentions the following:
A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists I (R = Me, X = 2-methoxy, 3-cyano, 3,5-Cl2, etc.; R = H, X = 3-cyano, 3-bromo, 3-methyl-5-fluoro, etc.) are described. The synthesis and pharmacol. activities of these analogs are discussed. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Application In Synthesis of 3-Cyanobenzoyl chloride).
3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 3-Cyanobenzoyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics