Design, synthesis and antitumor study of novel 1,4-bispiperazinecarbodithioic acid [1 -substituted-(1,2,3-triazole)-4]-methyl esters was written by Wang, Mengmeng;Duan, Yingchao;Ye, Xianwei;Ren, Jingli;Yu, Bin;Zhang, En;Liu, Hongmin. And the article was included in Youji Huaxue in 2013.Computed Properties of C7H5ClF2 This article mentions the following:
In order to find novel lead compounds with promising antitumor activity, a series of novel 1,4-bispiperazinecarbodithioic acid [1 -substituted-(1,2,3-triazole)-4]-Me esters were designed and synthesized. Piperazine reacting with CS2 and propargyl bromide in the presence of Na3PO4 · 12H2O in one pot gave compound 1, which was further reacted with appropriately substituted azide derivatives by click reaction to afford desired target compounds The structures were characterized by 1H NMR, 13C NMR and HRMS. The compounds were evaluated for antitumor activity against four selected human tumor cell lines of EC-9706, MGC-803, SMMC-7721 and MCF-7. Several compounds exhibited moderate to potent activity. Particularly, compound I was more potent than 5-fluorouracil against MGC-803 and SMMC-7721 with IC50 values of 11.15 and 14.75 μmol/L. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Computed Properties of C7H5ClF2).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C7H5ClF2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics