Synthesis of fungicide fluquinconazole was written by Wang, Guang-yu;Zhou, Yue-gen;Wang, Hui;Kong, Fan-lei. And the article was included in Nongyao in 2014.COA of Formula: C7H3Cl2NS This article mentions the following:
This article aims to study the synthetic route of fluquinconazole. Fluquinconazole was obtained from 2-amino-5-fluorobenzoic acid through reactions of condensation and ring-closure by one-pot method, chlorination and nucleophilic substitution. Under the optimal reaction conditions, the total yield of fluquinconazole was 67.1% based on 2-amino-5-fluorobenzoic acid, the purity was 99%. The structure was confirmed by HPLC-MS, 1H NMR. This method can be used as an effective path to synthesize fluquinconazole in industrial scale for the advantages of mild reaction condition and high yield. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1COA of Formula: C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics