Synthesis, spectral characterization and antimicrobial activity of thiourea/urea derivatives of amlodipine was written by Vedavathi, P.;Sekhar, K. Chandra;Raju, C. Naga. And the article was included in Pharmacia Lettre in 2013.Formula: C7H3Cl2NS This article mentions the following:
Amlodipine is one of the calcium channel blockers having dihydropyridine group, used as an antihypertensive drug. A series of novel ureaandthioureaderivativesofamlodipine(1) were prepared by reacting (1) with various substituted isocyanates/isothiocyanates in the presence of triethylamine in THF at 50 °C. Their structures were established by IR, 1H, 13CNMR, Mass spectral data and C, H, N elemental anal. Their antimicrobial activity was evaluated and the title compounds exhibited moderate antimicrobial activity. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics