Rhodium-Catalyzed Ring Expansion of Azetidines via Domino Conjugate Addition/N-Directed α-C(sp3)-H Activation was written by Sun, Ling-Zhi;Yang, Xuan;Li, Nan-Nan;Li, Meng;Ouyang, Qin;Xie, Jian-Bo. And the article was included in Organic Letters in 2022.Electric Literature of C19H15Cl This article mentions the following:
A facile synthetic method for 4-aryl-4,5-dihydropyrrole-3-carboxylates was developed, with a rhodium-catalyzed ring expansion strategy from readily available 2-(azetidin-3-ylidene) acetates and aryl boronic acids. Mechanistic investigations suggest a novel domino “conjugate addition/N-directed α-C(sp3)-H activation” process. The asym. catalytic synthesis of the 4-aryl-4,5-dihydropyrrole-3-carboxylate was realized by using QuinoxP* (91-97% ee). The synthetic utility of this protocol was demonstrated by the synthesis of 3,4-disubstituted or 2,3,4-trisubstituted pyrrolidines with excellent diastereoselectivities. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Electric Literature of C19H15Cl).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C19H15Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics