General catalytic methylation of amines with formic acid under mild reaction conditions was written by Sorribes, Ivan;Junge, Kathrin;Beller, Matthias. And the article was included in Chemistry – A European Journal in 2014.Category: chlorides-buliding-blocks This article mentions the following:
A general catalytic protocol for the methylation of amines was developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines was converted to the corresponding tertiary amines including [N-13C]-labeled drugs in good to excellent yields under mild conditions. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Category: chlorides-buliding-blocks).
2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics