Shao, Wu-Bin et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2020 | CAS: 620-19-9

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C8H9Cl

Antibacterial activities against Ralstonia solanacearum and Xanthomonas oryzae pv. oryzae of 6-chloro-4-(4-substituted piperazinyl)quinazoline derivatives was written by Shao, Wu-Bin;Zheng, Yu-Tao;Liu, Jia-Min;Fu, Yi-Hong;Qi, Pu-Ying;Zhou, Xiang;Wu, Zhi-Bing;Wang, Pei-Yi;Yang, Song. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.COA of Formula: C8H9Cl This article mentions the following:

In this letter, a variety of simple 6-chloro-4-(4-substituted piperazinyl)quinazoline derivatives was prepared Preliminary bioassays revealed that these compounds showed good antibacterial activities toward phytopathogens Ralstonia solanacearum and Xanthomonas oryzae pv. oryzae (Xoo). Among these derivatives, compounds I [X = 2-MeC6H4CO, 3-NO2C6H4CO, 4-FC6H4CO, 4-ClC6H4CO, 3,4-F2C6H3CO, 3-NO2-4-ClC6H3CO, 3-MeC6H4CH2, 4-ClC6H4CH2] exhibited potent inhibition effects against R. solanacearum with EC50 within 4.60-9.94μg/mL, especially, compound I [X = 4-BrC6H4CO]5g exerted the strongest activity with EC50 of 2.72μg/mL; compound I [X = 3-MeC6H4CH2] possessed the best inhibitory activity toward Xoo with EC50 of 8.46μg/mL. Subsequently, a good predictive three-dimensional quant. structure-activity relationship (3D-QSAR) model was constructed via CoMFA to direct the future structural modification and optimization. Furthermore, the pathogens’ topol. studies were performed to explore the possible antibacterial mechanism. Given their simple frameworks and facile synthesis, title compounds can serve as the potential antibacterial leads. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9COA of Formula: C8H9Cl).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C8H9Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics