Design and Synthesis of Fluoroquinolone Derivatives as Potent α-Glucosidase Inhibitors: In-Vitro Inhibitory Screening with In-Silico Docking Studies was written by Shaheen, Aasia;Ashiq, Uzma;Jamal, Rifat Ara;Khan, Khalid Mohammed;Gul, Sana;Yousuf, Sammer;Ali, Syed Tahir. And the article was included in ChemistrySelect in 2021.COA of Formula: C7H5ClF2 This article mentions the following:
This study was based on synthesis, structure elucidation and biol. evaluation of various fluoroquinolone (enoxacin) analogs with electrophilic substitution of aromatic amine moiety of central enoxacin nucleus by benzyl halides. The synthesized derivatives were characterized on the basis of different chem. and phys. measurements and structures were elucidated by various spectroscopic techniques (NMR, EI-MS), including elemental (CHN) and X-ray diffraction anal. Furthermore these compounds were investigated for their potential α-glucosidase inhibition activities and all synthesized analogs of fluoroquinolones were found to exhibit promising inhibition potential of 45.8±0.2 to 74.5±0.2μM in comparison to IC50 value of 425.6±1.3μM for standard inhibitor of α-glucosidase1-deoxynojirimycin. Further, docking of synthetic compounds were carried out by using α-glucosidase I enzyme of Saccharomyces cerevisiaeas a target. The study provided an insight of the mol. interactions of fluoroquinolone derivatives with the enzyme that were in good agreement with the inhibitory activity of synthesized compounds and can be considered as a valuable tool for designing new drugs. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C7H5ClF2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics