1,1,2-Triphenylbut-1-enes: relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties was written by Schneider, Martin R.;Von Angerer, Erwin;Schoenenberger, Helmut;Michel, Ralf T.;Fortmeyer, H. P.. And the article was included in Journal of Medicinal Chemistry in 1982.Synthetic Route of C9H9ClO2 This article mentions the following:
A structure-activity study was carried out on the title compounds I (R, R1, and R2 = H or OCOMe) with regard to estradiol [50-28-2] receptor affinity and to inhibiting effects on the growth of a postmenopausal human mammary carcinoma implanted in nude mice. The para-substituted compounds generally exhibited a higher receptor affinity and a better antitumor activity than the corresponding meta-substituted ones. The E isomers were superior to the resp. Z isomers in those 2 properties. The tumor-inhibiting effect of the mono- and disubstituted compounds was better than that of the trisubstituted ones. Except for the trisubstituted compounds, they all showed a good correlation between estradiol receptor affinity and antitumor activity. One of the compounds was also tested on the 9,10-dimethylbenz[a]anthracene-induced, hormone-dependent mammary carcinoma of the Sprague-Dawley rat and the results corresponded to those obtained in the xenograft tumor. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Synthetic Route of C9H9ClO2).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C9H9ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics