An “on-water” exploration of CuO nanoparticle catalysed synthesis of 2-aminobenzothiazoles was written by Rout, Saroj Kumar;Guin, Srimanta;Nath, Jayashree;Patel, Bhisma K.. And the article was included in Green Chemistry in 2012.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:
An “on-water” one-pot process has been engineered for the preparation of 2-aminobenzothiazole from ortho-halo (-F, -Cl, -Br and -I) substituted unsym. thioureas. For ortho -I and -Br substrates the reactions afford 2-aminobenzothiazoles under metal free condition promoted by base. However, the relatively inert ortho -Cl and -F substrates undergo intramol. arylthiolation only in the presence of CuO nanoparticles yielding 2-aminobenzothiazoles. This methodol. provides easy access to aminobenzothiazoles utilizing even the ortho -Cl and -F substrates. The catalyst is recyclable several times without loss of substantial activity. Other remarkable features include the wide range of functional group tolerance, absence of chromatog. purification (for ortho -I and -Br substrates) and providing moderate to excellent yield of the products under mild conditions, thus rendering the methodol. as a highly eco-friendly alternative to the existing methods. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics