Synthesis of some pyrazoles, pyrazolones and oxadiazoles bearing 2-arylamino-5-mercapto-1,3,4-thiadiazole nuclei as possible antimicrobial agents was written by Nair, Smitha;Garg, S. P.;Sah, Pramilla. And the article was included in Indian Journal of Heterocyclic Chemistry in 2002.Formula: C9H8ClNO4 This article mentions the following:
2-Arylamino-5-mercapto-1,3,4-thiadiazol-(3′-nitrophenyl)-4′-carbohydrazide (IV) was cyclized with pentane-2,4-dione to give the substituted pyrazoles (V). Reaction of IV with Et acetoacetate lead to the formation of 2-arylamino-5-mercapto-1,3,4-thiadiazol-(3′-nitrophenyl)-1”-carbonyl-3”-methyl-5(4H)-pyrazolones (VI). The hydrazide IV was also converted to 2”-(2-arylamino-5-mercapto-1,3,4-thiadiazol)-3′-nitrophenyl-1”,3”,4”-oxadiazolin-5”-thiones (VII) in presence of carbon disulfide and potassium hydroxide. Subsequent reaction of the thiones VII with secondary amines in presence of formaldehyde gave the title compounds All the compounds were evaluated for antibacterial and antifungal activities. Some of them are effective against the microbes. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Formula: C9H8ClNO4).
Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C9H8ClNO4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics