Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase was written by Milkiewicz, Karen L.;Weinberg, Linda R.;Albom, Mark S.;Angeles, Thelma S.;Cheng, Mangeng;Ghose, Arup K.;Roemmele, Renee C.;Theroff, Jay P.;Underiner, Ted L.;Zificsak, Craig A.;Dorsey, Bruce D.. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Quality Control of 2,5-Difluorophenylacetyl chloride This article mentions the following:
Dysregulation of the anaplastic lymphoma kinase (ALK) is implicated in a variety of cancers. A series of tetrahydropyrido[2,3-b]pyrazines was constructed as ring-constrained analogs of a known aminopyridine kinase scaffold. Chem. was developed to rapidly elaborate the SAR, structural elements impacting ALK inhibitory activity were exploited, and kinase selective analogs were identified that inhibit ALK with IC50 values â?0 nM (enzyme) and â?50 nM (cell). In the experiment, the researchers used many compounds, for example, 2,5-Difluorophenylacetyl chloride (cas: 157033-23-3Quality Control of 2,5-Difluorophenylacetyl chloride).
2,5-Difluorophenylacetyl chloride (cas: 157033-23-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 2,5-Difluorophenylacetyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics