Potent Non-Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors from Genetic Engineering of Streptomyces hygroscopicus was written by Menzella, Hugo G.;Tran, Thomas-Toan;Carney, John R.;Lau-Wee, Janice;Galazzo, Jorge;Reeves, Christopher D.;Carreras, Christopher;Mukadam, Sophie;Eng, Sara;Zhong, Ziyang;Timmermans, Pieter B. M. W. M.;Murli, Sumati;Ashley, Gary W.. And the article was included in Journal of Medicinal Chemistry in 2009.SDS of cas: 34662-36-7 This article mentions the following:
Inhibition of the protein chaperone Hsp90 is a promising new approach to cancer therapy. We describe the preparation of potent non-benzoquinone ansamycins. One of these analogs, generated by feeding 3-amino-5-chlorobenzoic acid to a genetically engineered strain of Streptomyces hygroscopicus, shows high accumulation and long residence time in tumor tissue, is well-tolerated upon i.v. dosing, and is highly efficacious in the COLO205 mouse tumor xenograft model. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7SDS of cas: 34662-36-7).
3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 34662-36-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics