Maloney, Patrick R. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2012 | CAS: 1711-11-1

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor was written by Maloney, Patrick R.;Khan, Pasha;Hedrick, Michael;Gosalia, Palak;Milewski, Monika;Li, Linda;Roth, Gregory P.;Sergienko, Eduard;Suyama, Eigo;Sugarman, Eliot;Nguyen, Kevin;Mehta, Alka;Vasile, Stefan;Su, Ying;Stonich, Derek;Nguyen, Hung;Zeng, Fu-Yue;Novo, Arianna Mangravita;Vicchiarelli, Michael;Diwan, Jena;Chung, Thomas D. Y.;Smith, Layton H.;Pinkerton, Anthony B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: chlorides-buliding-blocks This article mentions the following:

The recently discovered apelin/APJ system has emerged as a critical mediator of cardiovascular homeostasis and is associated with the pathogenesis of cardiovascular disease. A role for apelin/APJ in energy metabolism and gastrointestinal function has also recently emerged. We disclose the discovery and characterization of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221), a potent APJ functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. ML221 was derived from an HTS of the âˆ?30,600 compound MLSMR collection. This antagonist showed no significant binding activity against 29 other GPCRs, except to the κ-opioid and benzodiazepinone receptors (<50/<70%I at 10 μM). The synthetic methodol., development of structure-activity relationship (SAR), and initial in vitro pharmacol. characterization are also presented. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Category: chlorides-buliding-blocks).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics