Regiocontrolled palladium-catalyzed direct C2-arylations of Methoxalen using benzenesulfonyl chlorides and C2,C3-diarylations using aryl bromides as the aryl sources was written by Li, Haoran;Roisnel, Thierry;Soule, Jean-Francois;Doucet, Henri. And the article was included in Tetrahedron Letters in 2020.Synthetic Route of C7H4ClF3O2S This article mentions the following:
Conditions for the regioselective palladium-catalyzed direct C2-arylation and C2,C3-diarylation of methoxalen were described. The use of benzenesulfonyl chlorides as the coupling partner allowed control of the regioselectivity of the arylation in favor of the C2 carbon of methoxalen. This method tolerated a variety of substituents on the benzenesulfonyl chloride derivatives Notably, 2-, 3- and 4-bromobenzenesulfonyl chlorides and 4-iodobenzenesulfonyl chloride were coupled with methoxalen without cleavage of the C-Br or C-I bonds. Conversely, the use of an excess amount of aryl bromides as the aryl source provided access to C2,C3-diarlyated methoxalenes. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Synthetic Route of C7H4ClF3O2S).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClF3O2S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics