Cyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C-N bonds was written by Kong, Xianqiang;Wang, Yuchang;Chen, Yiyi;Chen, Xiaohui;Lin, Long;Cao, Zhong-Yan. And the article was included in Organic Chemistry Frontiers in 2022.Electric Literature of C8H10ClN This article mentions the following:
A practical and mild electrochem. protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C-N bond cleavage without the need for an external stoichiometric reducing agent or a sacrificial anode was developed. The reaction employed tosyl cyanide (TsCN) or azido allyl alc. as the cyanation or cyanomethylation reagent, resp. It showed high functional group compatibility and can be applied for the cyanation of natural product derivatives Preliminary mechanistic studies indicated the involvement of a radical addition pathway. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Electric Literature of C8H10ClN).
2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C8H10ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics