4-(1-benzyl-1H-benzo[d]imidazol-2-yl)-4-oxo-2-butenoic acid derivatives: design, synthesis and anti-HIV-1 activity was written by Karimi, Nafiseh;Roudsari, Rouhollah Vahabpour;Movahed, Mahsa Azami;Hajimahdi, Zahra;Zarghi, Afshin. And the article was included in Iranian Journal of Pharmaceutical Research in 2021.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
Integrase, targeted in highly active antiretroviral therapy (HAART), was a crucial enzyme in viral replication. In this study, new benzimidazolyl diketo acid derivatives I [R = Ph, 2-MeC6H4, 2-FC6H4, etc.] were designed according to required features for inhibitors of HIV-1 integrase. Designed compounds I were evaluated for anti-HIV-1 effects and docking studies indicated that the binding mode of compound I [R = 2-FC6H4] was similar to INSTIs. According to the cell-based biol. assay’s results, most of the tested compounds I demonstrated good anti-HIV-1 activity, ranging from 40-90μM concentration with no severe cytotoxicity. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics