Synthesis and antifungal activity of novel 2-(1H-benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole derivatives was written by Ji, Zengchen;Liu, Feng;Zhang, Zeyuan;Li, Fubo;Jiang, Lin. And the article was included in Youji Huaxue in 2012.Synthetic Route of C7H3Cl2NS This article mentions the following:
Sixteen novel 2-(1H-benzimidazol-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles I(R = H, 4-F, 4-Cl, 4-Br, 2,4-Cl2, 3,4-Cl2, 4-Me, 4-MeO) and 2-(1H-benzimidazol-2-yl)-5-substituted phenylamino-1,3,4-oxadiazoles II(R = H, 4-F, 4-Cl, 4-Br, 2,4-Cl2, 3,4-Cl2, 4-Me, 4-MeO) were synthesized from benzimidazole-2-carboxylic acid, hydrazine hydrate, substituted Ph isothiocyanate and substituted benzoic acid by multi-step reactions. The target compounds were evaluated for their antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum, and the results indicated that three target compounds displayed excellent antifungal activities against Botrytis cinerea, with EC50 values of 2.55, 6.34 and 5.12 μg/mL, resp., even higher than that of carbendazim. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C7H3Cl2NS
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics