Metal- and Oxidant-Free Green Three-Component Desulfurization and Deamination Condensation Approach to Fully Substituted 1H-1,2,4-Triazol-3-amines and Their Photophysical Properties was written by Guo, Wei;Liu, Gongping;Deng, Ling;Mei, Weijie;Zou, Xiaoying;Zhong, Yumei;Zhuo, Xiaoya;Fan, Xiaolin;Zheng, Lvyin. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 18637-02-0 This article mentions the following:
A metal-/oxidant-free three-component desulfurization and deamination condensation of amidines, isothiocyanates and hydrazines for the synthesis of structurally diverse full substituted 1H-1,2,4-triazol-3-amines I [R = Me, c-hexyl, Ph, etc.; R1 = Me, Ph, 3-pyridyl, etc.; R2 = c-hexyl, Ph, 2-pyridyl, etc.] was described. The reaction proceeded without the requirement of any external catalysts, metals, ligands and oxidants. This [2 + 1 + 2] cyclization strategy involved C-N/C-S bond cleavage and new C-N bonds formation in one pot. This transformation provided a series of full substituted 1H-1,2,4-triazol-3-amines with advantages of broad substrates scope, mild reaction conditions, environmental friendliness and easily gram-scale applications. The fluorescence and aggregation-induced emission (AIE) properties of selected products were further tested. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0SDS of cas: 18637-02-0).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 18637-02-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics