Associations between a mixture of phenols and phthalates and child behaviour in a French mother-child cohort with repeated assessment of exposure was written by Guilbert, Ariane;Rolland, Matthieu;Pin, Isabelle;Thomsen, Cathrine;Sakhi, Amrit K.;Sabaredzovic, Azemira;Slama, Remy;Guichardet, Karine;Philippat, Claire. And the article was included in Environment International in 2021.SDS of cas: 101-20-2 This article mentions the following:
Synthetic phenols and phthalates can interfere with biol. pathways involved in brain development. Despite the high within-subject temporal variability of urinary concentrations observed for their metabolites, studies investigating effects of phenols and phthalates on child behavior often relied on a limited number of spot biospecimens to assess exposure. Besides, the majority did not consider mixture effects. To study the combined effect of prenatal exposure to synthetic phenols and phthalates on child behavior using repeated exposure measurements. We assessed concentrations of 12 phenols, 13 phthalate and 2 non-phthalate plasticizer metabolites in within-subject pools of multiple urine samples (median = 21 samples per individual pool) collected at two distinct time points during pregnancy in 416 mother-child pairs from the French SEPAGES cohort. Child behavior was evaluated at two years using the Child Behavior Checklist 1.5-5 (CBCL). Associations between a mixture of biomarkers of exposure and externalizing and internalizing behavior scores were studied using adjusted Weighted Quantile Sum (WQS) regressions with a repeated holdout validation (100 repetitions). The pos. WQS indexes were associated with both the externalizing and internalizing behavior scores in the whole population, indicating greater risk of behavioral problems. Stratification for child sex suggested stronger associations in girls than boys. On average, girls externalizing and internalizing scores increased by 3.67 points (95% CI: 1.24, 6.10) and 2.47 points (95%CI: 0.60, 4.33) resp., for an increase of one tertile in the WQS index, compared with 1.70 points (95%CI: -0.42, 3.81) and 1.17 points (95%CI: -0.50, 2.84) in boys. Main contributors for the associations observed in girls were bisphenol A (weight of 18%), triclosan (17%) and monoethyl phthalate (MEP, 15%) for the externalizing score and MEP (19%), mono-benzyl phthalate (MBzP, 19%) and mono-Bu phthalate (MnBP, 16%) for the internalizing score. Our results suggest adverse associations between in utero exposure to a mixture of phenols and phthalates and child behavior, mainly in girls. Public health consequences may be substantial due to the widespread exposure of the population to these compounds In the experiment, the researchers used many compounds, for example, 1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2SDS of cas: 101-20-2).
1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea (cas: 101-20-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 101-20-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics